Search Results - "Goldfinger, Lawrence E."

Platelet Microparticles and miRNA Transfer in Cancer Progression: Many Targets, Modes of Action, and Effects Across Cancer Stages by Lazar, Sophia, Goldfinger, Lawrence E

“…Platelet-derived microparticles (PMPs) have long been known to increase in circulation in the presence of cancer, and have been considered to be cancer…”
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Platelet microRNAs inhibit primary tumor growth via broad modulation of tumor cell mRNA expression in ectopic pancreatic cancer in mice by Wurtzel, Jeremy G T, Lazar, Sophia, Sikder, Sonali, Cai, Kathy Q, Astsaturov, Igor, Weyrich, Andrew S, Rowley, Jesse W, Goldfinger, Lawrence E

“…We investigated the contributions of platelet microRNAs (miRNAs) to the rate of growth and regulation of gene expression in primary ectopic tumors using mouse…”
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High-efficiency unassisted transfection of platelets with naked double-stranded miRNAs modulates signal-activated translation and platelet function by Lazar, Sophia, Wurtzel, Jeremy G.T., Chen, Xi, Ma, Peisong, Goldfinger, Lawrence E.

“…We sought novel approaches to improve transfection efficiencies of microRNAs (miRNAs) in platelets, and to apply these approaches to investigate the roles of…”
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Platelets and extracellular vesicles and their cross talk with cancer by Lazar, Sophia, Goldfinger, Lawrence E.

“…Platelets play significant and varied roles in cancer progression, as detailed throughout this review series, via direct interactions with cancer cells and by…”
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The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and Rac signaling, cell spreading and migration by Lee, Seunghyung, Wurtzel, Jeremy G.T., Goldfinger, Lawrence E.

“…•RLIP76 is an adapter protein controlling cell spreading and migration via Arf6 and Rac.•RLIP76 N-terminal Serines regulate binding ARNO and activation of Arf6…”
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Inhibition of Galectin-1 Sensitizes HRAS-driven Tumor Growth to Rapamycin Treatment by Michael, James V, Wurtzel, Jeremy G T, Goldfinger, Lawrence E

“…The goal of this study was to develop combinatorial application of two drugs currently either in active use as anticancer agents (rapamycin) or in clinical…”
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RALBP1/RLIP76 Depletion in Mice Suppresses Tumor Growth by Inhibiting Tumor Neovascularization by LEE, Seunghyung, WURTZEL, Jeremy G. T, SINGHAL, Sharad S, AWASTHI, Sanjay, GOLDFINGER, Lawrence E

“…RalBP1/RLIP76 is a widely expressed multifunctional protein that binds the Ral and R-Ras small GTPases. In the mouse, RLIP76 is nonessential but its depletion…”
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Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency by Jalagadugula, Gauthami, Mao, Guangfen, Kaur, Gurpreet, Goldfinger, Lawrence E., Dhanasekaran, Danny N., Rao, A. Koneti

“…Mutations in transcription factor RUNX1 are associated with familial platelet disorder, thrombocytopenia, and predisposition to leukemia. We have described a…”
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Regulation of Ras signaling and function by plasma membrane microdomains by Goldfinger, Lawrence E., Michael, James V.

“…Together H-, N- and KRAS mutations are major contributors to ~30% of all human cancers. Thus, Ras inhibition remains an important anti-cancer strategy. The…”
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Integrin-mediated protein kinase A activation at the leading edge of migrating cells by Lim, Chinten J, Kain, Kristin H, Tkachenko, Eugene, Goldfinger, Lawrence E, Gutierrez, Edgar, Allen, Michael D, Groisman, Alex, Zhang, Jin, Ginsberg, Mark H

“…cAMP-dependent protein kinase A (PKA) is important in processes requiring localized cell protrusion, such as cell migration and axonal path finding. Here, we…”
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Choose your own path: specificity in Ras GTPase signaling by Goldfinger, Lawrence E

“…The Ras superfamily of small G proteins contributes importantly to numerous cellular and physiological processes (M. F. Olsen and R. Marais, Semin. Immunol.,…”
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Three-Dimensional Reconstruction of Neovasculature in Solid Tumors and Basement Membrane Matrix Using Ex Vivo X-ray Microcomputed Tomography by Lee, Seunghyung, Barbe, Mary F., Scalia, Rosario, Goldfinger, Lawrence E.

“…Objective To create accurate, high‐resolution 3D reconstructions of neovasculature structures in xenografted tumors and Matrigel plugs for quantitative…”
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GPVI inhibitor as antitumor gateway drug by Goldfinger, Lawrence E.

“…In this issue of Blood , Volz et al establish a potential antitumor strategy by exploiting the selective requirement for platelets to maintain vascular…”
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GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets by Chen, Xi, Gupta, Shuchi, Cooper, Matthew, DeHelian, Daniel, Zhao, Xuefei, Naik, Meghna U., Wurtzel, Jeremy G.T., Stalker, Timothy J., Goldfinger, Lawrence E., Benovic, Jeffrey, Brass, Lawrence F., McKenzie, Steven E., Naik, Ulhas P., Ma, Peisong

“…G protein–coupled receptors (GPCRs) mediate the majority of platelet activation in response to agonists. However, questions remain regarding the mechanisms…”
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Defective RAB1B-related megakaryocytic ER-to-Golgi transport in RUNX1 haplodeficiency: impact on von Willebrand factor by Jalagadugula, Gauthami, Goldfinger, Lawrence E., Mao, Guangfen, Lambert, Michele P., Rao, A. Koneti

“…Patients with RUNX1 haplodeficiency have thrombocytopenia, platelet dysfunction, and deficiencies of α-granules and dense granules. Platelet expression…”
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Palmitoylation regulates vesicular trafficking of R-Ras to membrane ruffles and effects on ruffling and cell spreading by Wurtzel, Jeremy G.T., Kumar, Puneet, Goldfinger, Lawrence E.

“…In this study we investigated the dynamics of R-Ras intracellular trafficking and its contributions to the unique roles of R-Ras in membrane ruffling and cell…”
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Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth by Michael, James V., Wurtzel, Jeremy G.T., Mao, Guang Fen, Rao, A.Koneti, Kolpakov, Mikhail A., Sabri, Abdelkarim, Hoffman, Nicholas E., Rajan, Sudarsan, Tomar, Dhanendra, Madesh, Muniswamy, Nieman, Marvin T., Yu, Johnny, Edelstein, Leonard C., Rowley, Jesse W., Weyrich, Andrew S., Goldfinger, Lawrence E.

“…Platelet-derived microparticles (PMPs) are associated with enhancement of metastasis and poor cancer outcomes. Circulating PMPs transfer platelet microRNAs…”
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Processing of Laminin-5 and Its Functional Consequences: Role of Plasmin and Tissue-Type Plasminogen Activator by Goldfinger, Lawrence E., Stack, M. Sharon, Jonathan C. R. Jones

“…The laminin-5 component of the extracellular matrices of certain cultured cells such as the rat epithelial cell line 804G and the human breast epithelial cell…”
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RLIP76 regulates HIF‐1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells by Lee, Seunghyung, Goldfinger, Lawrence E.

“…This study was undertaken to reveal the mechanisms by which RLIP76 regulates endothelial cell angiogenic responses. RLIP76 is an effector of the angiogenic…”
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Concepts and advances in cancer therapeutic vulnerabilities in RAS membrane targeting by Michael, James V., Goldfinger, Lawrence E.

“…For decades oncogenic RAS proteins were considered undruggable due to a lack of accessible binding pockets on the protein surfaces. Seminal early research in…”
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