Search Results - "Goldfarb, Ronald H."

In Vitro Assessment of Human Natural Killer Cell Migration and Invasion by Tomin, Karin, Goldfarb, Ronald H, Albertsson, Per

“…Cell invasion assays are important to obtain valuable functional data relating to tissue migration and invasion of effector lymphocytes. Boyden chamber…”
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Tumor‐localization by adoptively transferred, interleukin‐2‐activated NK cells leads to destruction of well‐established lung metastases by Yang, Qin, Hokland, Marianne E., Bryant, John L., Zhang, Yuquing, Nannmark, Ulf, Watkins, Simon C., Goldfarb, Ronald H., Herberman, Ronald B., Basse, Per H.

“…We have shown previously that i.v. injection of interleukin‐2‐(IL‐2) activated natural killer (A‐NK) cells together with IL‐2 leads to a substantial…”
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The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions by McEwen, Bruce S, Biron, Christine A, Brunson, Kenneth W, Bulloch, Karen, Chambers, William H, Dhabhar, Firdaus S, Goldfarb, Ronald H, Kitson, Richard P, Miller, Andrew H, Spencer, Robert L, Weiss, Jay M

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Matrix Metalloproteinases in Cytotoxic Lymphocytes Impact on Tumour Infiltration and Immunomodulation by Edsparr, Karin, Basse, Per H., Goldfarb, Ronald H., Albertsson, Per

“…To efficiently combat solid tumours, endogenously or adoptively transferred cytotoxic T cells and natural killer (NK) cells, need to leave the vasculature,…”
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NK cells and the tumour microenvironment: implications for NK-cell function and anti-tumour activity by Albertsson, Per A., Basse, Per H., Hokland, Marianne, Goldfarb, Ronald H., Nagelkerke, J.Fred, Nannmark, Ulf, Kuppen, Peter J.K.

“…Although it is clear that natural killer (NK) cells have the ability to recognize and kill tumour cells in vitro, their potential as a highly effective…”
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Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts by An, B, Goldfarb, R H, Siman, R, Dou, Q P

“…It has been suggested that overexpression of the Bcl-2 oncoprotein in human cancer cells contributes to their resistance to apoptosis induced by chemotherapy…”
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A KDR-binding peptide (ST100,059) can block angiogenesis, melanoma tumor growth and metastasis in vitro and in vivo by RASTELLI, Luca, VALENTINO, Maria Luisa, GOLDFARB, Ronald H, RABBANI, Shafaat A, CORSO MINDERMAN, Melissa, LANDIN, Judith, MALYANKAR, Uriel M, LESCOE, Mary K, KITSON, Richard, BRUNSON, Kenneth, SOUAN, Lina, FORENZA, Salvatore

“…A major goal of treatment strategies for cancer is the development of agents which can block primary tumor growth and development as well as the progression of…”
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Effects of IL-2 on MMP Expression in Freshly Isolated Human NK Cells and the IL-2-independent NK Cell Line YT by EDSPARR, Karin, SPEETJENS, Frank M, MULDER-STAPEL, Adri, GOLDFARB, Ronald H, BASSE, Per H, LENNERNDS, Bo, KUPPEN, Peter J. K, ALBERTSSON, Per

“…Interleukin-2 is an important activation factor for natural killer (NK) cells but its effect on NK cell matrix metalloproteinases (MMP) production and matrix…”
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The urokinase plasminogen activator system in cancer : Implications for tumor angiogenesis and metastasis by MAZAR, A. P, HENKIN, J, GOLDFARB, R. H

“…Substantial evidence exists which implicates the urokinase plasminogen activator system [urokinase plasminogen activator (uPA), urokinase plasminogen activator…”
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Human NK cell lines migrate differentially in vitro related to matrix interaction and MMP expression by Edsparr, Karin, Johansson, Bengt R, Goldfarb, Ronald H, Basse, Per H, Nannmark, Ulf, Speetjens, Frank M, Kuppen, Peter JK, Lennernäs, Bo, Albertsson, Per

“…Matrix metalloproteinases (MMPs) are thought to be of importance for the migratory ability of natural killer (NK) cells. Their expression and production may…”
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Physical association of uPAR with the α V integrin on the surface of human NK cells by Gellert, Ginelle C, Goldfarb, Ronald H, Kitson, Richard P

“…The urokinase-type plasminogen activator receptor (uPAR) serves as a receptor for urokinase plasminogen activator (uPA) and plays a role in invasion and…”
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Different mechanisms of soy isoflavones in cell cycle regulation and inhibition of invasion by Kim, Myoung H, Gutierrez, Angelica M, Goldfarb, Ronald H

“…Soy isoflavones, genistein, daidzein and glycitein, are thought to have beneficial effects on cancer prevention. We used cell cycle analysis, invasion assay…”
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Differential effects of proteasome inhibitors on cell cycle and apoptotic pathways in human YT and Jurkat cells by Lu, Min, Dou, Q. Ping, Kitson, Richard P., Smith, David M., Goldfarb, Ronald H.

“…Herein, we report differential effects of various proteasome inhibitors including clasto‐lactacystin‐β‐lactone, (−)‐epigallocatechin gallate (EGCG) and…”
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Secreted and Membrane-Associated Matrix Metalloproteinases of IL-2-Activated NK Cells and Their Inhibitors by Kim, Myoung H, Kitson, Richard P, Albertsson, Per, Nannmark, Ulf, Basse, Per H, Kuppen, Peter J. K, Hokland, Marianne E, Goldfarb, Ronald H

“…We have previously documented that rat IL-2-activated NK (A-NK) cells produce matrix metalloproteinase-2 (MMP-2) and MMP-9. In this study, we describe mouse…”
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Conformational and enzymatic changes of 20S proteasome of rat natural killer cells induced by mono- and divalent cations by Reshetnyak, Yana K, Kitson, Richard P, Lu, Min, Goldfarb, Ronald H

“…We have been investigated the relation between activation of “neutral” and “acidic” chymotrypsin-like (ChT-L) activity and conformational changes in the 20S…”
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Urokinase-type plasminogen activator receptor crosslinking in an NK cell line increases integrin surface expression by the MAP kinase/ERK 1/2 signaling pathway by Gellert, Ginelle C., Kitson, Richard P., Goldfarb, Ronald H.

“…Urokinase‐type plasminogen activator receptor (uPAR) is attached to cell membranes by a glycosylphosphatidylinositol (GPI) anchor, and as such is devoid of an…”
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2B4(CD244)-mediated activation of NK cells reduces metastases of B16F10 melanoma in mice by Johnson, Lori A, Vaidya, Swapnil V, Goldfarb, Ronald H, Mathew, Porunelloor A

“…Natural killer (NK) cells are a third population of lymphocytes that can kill certain tumor cells. This killing is regulated by signals received through…”
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Activation of multiple caspases and modification of cell surface fas (CD95) in proteasome inhibitor-induced apoptosis of rat natural killer cells by Lu, Min, Kitson, Richard P., Xue, Yaming, Goldfarb, Ronald H.

“…The proteasome is a multi‐subunit protease complex that is involved in intracellular protein degradation in eukaryotes. Previously, we have reported that…”
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Tumor structure and extracellular matrix as a possible barrier for therapeutic approaches using immune cells or adenoviruses in colorectal cancer by Kuppen, P J, van der Eb, M M, Jonges, L E, Hagenaars, M, Hokland, M E, Nannmark, U, Goldfarb, R H, Basse, P H, Fleuren, G J, Hoeben, R C, van de Velde, C J

“…In this article we report about the role that tumor structure and extracellular matrix (ECM) may play in immunotherapy and in gene therapy using adenoviruses…”
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IL-2-Mediated Upregulation of uPA and uPAR in Natural Killer Cells by Al-Atrash, Gheath, Shetty, Sreerama, Idell, Steven, Xue, Yaming, Kitson, Richard P., Halady, Prathap Kumar Shetty, Goldfarb, Ronald H.

“…Urokinase plasminogen activator (uPA) and its receptor uPAR play a major role in immune cell-mediated, including natural killer (NK) cell-mediated, degradation…”
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