Search Results - "Golder, Francis J."

Spinal Synaptic Enhancement with Acute Intermittent Hypoxia Improves Respiratory Function after Chronic Cervical Spinal Cord Injury by Golder, Francis J, Mitchell, Gordon S

“…Respiratory insufficiency is the leading cause of death after high-cervical spinal cord injuries (SCIs). Although respiratory motor recovery can occur with…”
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Respiratory stimulant drugs in the post-operative setting by Golder, Francis J, Hewitt, Matthew M, McLeod, James F

“…Highlights • Post-surgical respiratory depression is a serious clinical unmet need. • Few pharmacotherapeutic agents are available to treat post-surgical…”
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Neuronal hyperexcitability in the dorsal horn after painful facet joint injury by Quinn, Kyle P., Dong, Ling, Golder, Francis J., Winkelstein, Beth A.

“…Excessive cervical facet capsular ligament stretch has been implicated as a cause of whiplash-associated disorders following rear-end impacts, but the…”
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Spinal Adenosine A2a Receptor Activation Elicits Long-Lasting Phrenic Motor Facilitation by Golder, Francis J, Ranganathan, Lavanya, Satriotomo, Irawan, Hoffman, Michael, Lovett-Barr, Mary Rachael, Watters, Jyoti J, Baker-Herman, Tracy L, Mitchell, Gordon S

“…Acute intermittent hypoxia elicits a form of spinal, brain-derived neurotrophic factor (BDNF)-dependent respiratory plasticity known as phrenic long-term…”
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Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator by Golder, Francis J, Dax, Scott, Baby, Santhosh M, Gruber, Ryan, Hoshi, Toshinori, Ideo, Courtney, Kennedy, Andrew, Peng, Sean, Puskovic, Veljko, Ritchie, David, Woodward, Richard, Wardle, Robert L, Van Scott, Michael R, Mannion, James C, MacIntyre, D Euan

“…BACKGROUND:The authors describe the preclinical pharmacological properties of GAL-021, a novel peripheral chemoreceptor modulator. METHODS:The ventilatory…”
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BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia by Mitchell, Gordon S, Baker-Herman, Tracy L, Fuller, David D, Bavis, Ryan W, Zabka, Andrea G, Golder, Francis J, Doperalski, Nicholas J, Johnson, Rebecca A, Watters, Jyoti J

“…Intermittent hypoxia causes a form of serotonin-dependent synaptic plasticity in the spinal cord known as phrenic long-term facilitation (pLTF). Here we show…”
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GAL-021 and GAL-160 are Efficacious in Rat Models of Obstructive and Central Sleep Apnea and Inhibit BKCa in Isolated Rat Carotid Body Glomus Cells by Dallas, Mark L, Peers, Chris, Golder, Francis J, Baby, Santhosh, Gruber, Ryan, MacIntyre, D Euan

“…GAL-021 and GAL-160 are alkylamino triazine analogues, which stimulate ventilation in rodents, non-human primates and (for GAL-021) in humans. To probe the…”
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Recovery of phrenic activity and ventilation after cervical spinal hemisection in rats by Fuller, David D, Golder, Francis J, Olson, E. B., Jr, Mitchell, Gordon S

“…Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin Submitted 5 August 2005 ; accepted in final…”
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Receptor tyrosine kinases and respiratory motor plasticity by Golder, Francis J

“…Abstract Protein kinases are a family of enzymes that transfer a phosphate group from adenosine tri-phosphate to an amino acid residue on a protein. The…”
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Bilateral vagotomy differentially alters the magnitude of hypoglossal and phrenic long-term facilitation in anesthetized mechanically ventilated rats by Golder, Francis J., Martinez, Sharon D.

“…Acute intermittent hypoxia elicits long-term increases in respiratory motor output (long-term facilitation, LTF). Most investigators study LTF in mechanically…”
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Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptors by Fuller, David D, Baker-Herman, Tracy L, Golder, Francis J, Doperalski, Nicholas J, Watters, Jyoti J, Mitchell, Gordon S

“…Following chronic C2 spinal hemisection (C2HS), crossed spinal pathways to phrenic motoneurons exhibit a slow, spontaneous increase in efficacy by a serotonin…”
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Respiratory Motor Recovery after Unilateral Spinal Cord Injury: Eliminating Crossed Phrenic Activity Decreases Tidal Volume and Increases Contralateral Respiratory Motor Output by Golder, Francis J, Fuller, David D, Davenport, Paul W, Johnson, Richard D, Reier, Paul J, Bolser, Donald C

“…By 2 months after unilateral cervical spinal cord injury (SCI), respiratory motor output resumes in the previously quiescent phrenic nerve. This activity is…”
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Suspected epidural morphine analgesia induced chronic urinary and bowel dysfunction in a cat by Song, Rachel B., Cross, Johnny R., Golder, Francis J., Callan, Mary Beth

“…A 12-year-old male castrated domestic shorthair developed chronic urinary retention, constipation and a decreased perineal reflex following a single…”
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Altered Respiratory Motor Drive after Spinal Cord Injury: Supraspinal and Bilateral Effects of a Unilateral Lesion by Golder, Francis J, Reier, Paul J, Bolser, Donald C

“…Because some bulbospinal respiratory premotor neurons have bilateral projections to the phrenic nuclei, we investigated whether changes in contralateral…”
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Suspected acute meperidine toxicity in a dog by Golder, Francis J, Wilson, Jeffrey, Larenza, M Paula, Fink, Owen T

“…A 22-month-old male neutered Coton De Tulear dog was presented for upper gastrointestinal endoscopy under general anesthesia. The anesthetic plan included…”
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Cervical spinal cord injury alters the pattern of breathing in anesthetized rats by Golder, Francis J, Reier, Paul J, Davenport, Paul W, Bolser, Donald C

“…1  Department of Physiological Sciences, College of Veterinary Medicine, and 2  Department of Neuroscience, College of Medicine, University of Florida,…”
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Differences in time-dependent hypoxic phrenic responses among inbred rat strains by Golder, Francis J, Zabka, Andrea G, Bavis, Ryan W, Baker-Herman, Tracy, Fuller, David D, Mitchell, Gordon S

“…Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin Submitted 7 September 2004 ; accepted in final form 31 October 2004 Hypoxic…”
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Anesthetic and physiologic effects of tiletamine, zolazepam, ketamine, and xylazine combination (TKX) in feral cats undergoing surgical sterilization by Cistola, Alexis M., Golder, Francis J., Centonze, Lisa A., McKay, Lindsay W., Levy, Julie K.

“…Tiletamine (12.5 mg), zolazepam (12.5 mg), ketamine (20 mg), and xylazine (5 mg) (TKX; 0.25 ml, IM) combination was evaluated as an anesthetic in 22 male and…”
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Augmented breath phase volume and timing relationships in the anesthetized rat by Golder, Francis J., Davenport, Paul W., Johnson, Richard D., Reier, Paul J., Bolser, Donald C.

“…Augmented breaths (ABs), or sighs, are airway protective reflexes and part of the normal repertoire of respiratory behaviors. ABs consist of two phases, where…”
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Gray matter repair in the cervical spinal cord by Reier, Paul J, Golder, Francis J, Bolser, Donald C, Hubscher, Charles, Johnson, Richard, Schrimsher, Gregory W, Velardo, Margaret J

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