No evidence for cerebellar abnormality in adults with developmental dyslexia

No evidence for cerebellar abnormality in adults with developmental dyslexia

Developmental dyslexia is commonly believed to result from a deficiency in the recognition and processing of speech sounds. According to the cerebellar deficit hypothesis, this phonological deficit is caused by deficient cerebellar function. In the current study, 26 adults with developmental dyslexi...

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Bibliographic Details
Published in:Experimental brain research Vol. 236; no. 11; pp. 2991 - 3001
Main Authors: van Oers, Casper A. M. M., Goldberg, Nadya, Fiorin, Gaetano, van den Heuvel, Martijn P., Kappelle, L. Jaap, Wijnen, Frank N. K.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-11-2018
Springer Nature B.V
Subjects:
Adolescent
Adult
Biomedical and Life Sciences
Biomedicine
Brain Mapping
Cerebellum
Cerebellum - diagnostic imaging
Dyslexia
Dyslexia - diagnostic imaging
Female
Humans
Hypotheses
Magnetic Resonance Imaging
Male
Morphometry
Neural networks
Neurodevelopmental disorders
Neurology
Neurosciences
Reading
Reading disabilities
Research Article
Structure-function relationships
Substantia alba
Substantia grisea
Young Adult
Cerebellum
Dyslexia
MRI
Voxel-based morphometry
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Summary:Developmental dyslexia is commonly believed to result from a deficiency in the recognition and processing of speech sounds. According to the cerebellar deficit hypothesis, this phonological deficit is caused by deficient cerebellar function. In the current study, 26 adults with developmental dyslexia and 25 non-dyslexic participants underwent testing of reading-related skills, cerebellar functions, and MRI scanning of the brain. Anatomical assessment of the cerebellum was conducted with voxel-based morphometry. Behavioural evidence, that was indicative of impaired cerebellar function, was found to co-occur with reading impairments in the dyslexic subjects, but a causal relation between the two was not observed. No differences in local grey matter volume, nor in structure–function relationships within the cerebellum were found between the two groups. Possibly, the observed behavioural pattern is due to aberrant white matter connectivity. In conclusion, no support for the cerebellar deficit hypothesis or the presence of anatomical differences of the cerebellum in adults with developmental dyslexia was found.
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ISSN:0014-4819
1432-1106
DOI:10.1007/s00221-018-5351-y