Search Results - "Goldberg, Alfred L"

Development of proteasome inhibitors as research tools and cancer drugs by Goldberg, Alfred L

“…The proteasome is the primary site for protein degradation in mammalian cells, and proteasome inhibitors have been invaluable tools in clarifying its cellular…”
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Proteasome-Mediated Processing of Nrf1 Is Essential for Coordinate Induction of All Proteasome Subunits and p97 by Sha, Zhe, Goldberg, Alfred L.

“…Proteasome inhibitors are widely used in the treatment of multiple myeloma and as research tools. Additionally, diminished proteasome function may contribute…”
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Muscle wasting in disease: molecular mechanisms and promising therapies by Cohen, Shenhav, Nathan, James A., Goldberg, Alfred L.

“…Key Points Muscle wasting is a debilitating condition that develops with ageing and more rapidly with inactivity (bed rest) and in various systemic diseases…”
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SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth by Lee, Donghoon, Goldberg, Alfred L.

“…In several cell types, the protein deacetylase SIRT1 regulates the activities of FoxO transcription factors whose activation is critical in muscle atrophy…”
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The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis by Kim, Hyoung Tae, Goldberg, Alfred L.

“…The proteasome-associated deubiquitinating enzyme Usp14/Ubp6 inhibits protein degradation by catalyzing substrate deubiquitination and by poorly understood…”
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UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells by Kim, Hyoung Tae, Goldberg, Alfred L.

“…The best-known function of ubiquitin-like (UBL) domains in proteins is to enable their binding to 26S proteasomes. The proteasome-associated deubiquitinating…”
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Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy by Milan, Giulia, Romanello, Vanina, Pescatore, Francesca, Armani, Andrea, Paik, Ji-Hye, Frasson, Laura, Seydel, Anke, Zhao, Jinghui, Abraham, Reimar, Goldberg, Alfred L., Blaauw, Bert, DePinho, Ronald A., Sandri, Marco

“…Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic state characterized by enhanced muscle proteolysis and amino acid…”
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The influence of skeletal muscle on systemic aging and lifespan by Demontis, Fabio, Piccirillo, Rosanna, Goldberg, Alfred L., Perrimon, Norbert

“…Summary Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the development of several age‐related diseases such as…”
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Coordinate regulation of autophagy and the ubiquitin proteasome system by MTOR by Zhao, Jinghui, Goldberg, Alfred L.

“…Proteins in eukaryotic cells are continually being degraded to amino acids either by the ubiquitin proteasome system (UPS) or by the autophagic-lysosomal…”
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Myostatin/activin pathway antagonism: Molecular basis and therapeutic potential by Han, H.Q., Zhou, Xiaolan, Mitch, William E., Goldberg, Alfred L.

“…Muscle wasting is associated with a wide range of catabolic diseases. This debilitating loss of muscle mass and functional capacity reduces the quality of life…”
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Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis by Qian, Min-Xian, Pang, Ye, Liu, Cui Hua, Haratake, Kousuke, Du, Bo-Yu, Ji, Dan-Yang, Wang, Guang-Fei, Zhu, Qian-Qian, Song, Wei, Yu, Yadong, Zhang, Xiao-Xu, Huang, Hai-Tao, Miao, Shiying, Chen, Lian-Bin, Zhang, Zi-Hui, Liang, Ya-Nan, Liu, Shan, Cha, Hwangho, Yang, Dong, Zhai, Yonggong, Komatsu, Takuo, Tsuruta, Fuminori, Li, Haitao, Cao, Cheng, Li, Wei, Li, Guo-Hong, Cheng, Yifan, Chiba, Tomoki, Wang, Linfang, Goldberg, Alfred L., Shen, Yan, Qiu, Xiao-Bo

“…Histone acetylation plays critical roles in chromatin remodeling, DNA repair, and epigenetic regulation of gene expression, but the underlying mechanisms are…”
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Protein degradation by the ubiquitin-proteasome pathway in normal and disease states by LECKER, Stewart H, GOLDBERG, Alfred L, MITCH, William E

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Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy by Cohen, Shenhav, Zhai, Bo, Gygi, Steven P, Goldberg, Alfred L

“…During muscle atrophy, myofibrillar proteins are degraded in an ordered process in which MuRF1 catalyzes ubiquitylation of thick filament components (Cohen et…”
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Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models by Demontis, Fabio, Piccirillo, Rosanna, Goldberg, Alfred L, Perrimon, Norbert

“…A characteristic feature of aged humans and other mammals is the debilitating, progressive loss of skeletal muscle function and mass that is known as…”
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Mechanisms of muscle growth and atrophy in mammals and Drosophila by Piccirillo, Rosanna, Demontis, Fabio, Perrimon, Norbert, Goldberg, Alfred L.

“…Background: The loss of skeletal muscle mass (atrophy) that accompanies disuse and systemic diseases is highly debilitating. Although the pathogenesis of this…”
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Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival by Zhou, Xiaolan, Wang, Jin Lin, Lu, John, Song, Yanping, Kwak, Keith S., Jiao, Qingsheng, Rosenfeld, Robert, Chen, Qing, Boone, Thomas, Simonet, W. Scott, Lacey, David L., Goldberg, Alfred L., Han, H.Q.

“…Muscle wasting and cachexia have long been postulated to be key determinants of cancer-related death, but there has been no direct experimental evidence to…”
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Immuno- and Constitutive Proteasomes Do Not Differ in Their Abilities to Degrade Ubiquitinated Proteins by Nathan, James A., Spinnenhirn, Valentina, Schmidtke, Gunter, Basler, Michael, Groettrup, Marcus, Goldberg, Alfred L.

“…Immunoproteasomes are alternative forms of proteasomes that have an enhanced ability to generate antigenic peptides. Recently, Seifert and colleagues reported…”
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Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins by Medicherla, Balasubrahmanyam, Goldberg, Alfred L

“…Accumulation of misfolded oxidant-damaged proteins is characteristic of many diseases and aging. To understand how cells handle postsynthetically damaged…”
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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo by Mammucari, Cristina, Milan, Giulia, Romanello, Vanina, Masiero, Eva, Rudolf, Ruediger, Del Piccolo, Paola, Burden, Steven J., Di Lisi, Raffaella, Sandri, Claudia, Zhao, Jinghui, Goldberg, Alfred L., Schiaffino, Stefano, Sandri, Marco

“…Autophagy allows cell survival during starvation through the bulk degradation of proteins and organelles by lysosomal enzymes. However, the mechanisms…”
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Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation by Sha, Zhe, Goldberg, Alfred L.

“…An important adaptation of cells to proteasome inhibition is the induction of new proteasomes via the transcription factor Nrf1 [1,2], which is produced as a…”
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