Search Results - "Goldberg, A L"

Atrogin-1, A Muscle-Specific F-Box Protein Highly Expressed during Muscle Atrophy by Gomes, Marcelo D., Lecker, Stewart H., Jagoe, R. Thomas, Navon, Ami, Goldberg, Alfred L.

“…Muscle wasting is a debilitating consequence of fasting, inactivity, cancer, and other systemic diseases that results primarily from accelerated protein…”
Get full text

What do we really know about the ubiquitin-proteasome pathway in muscle atrophy? by Jagoe, R. T., Goldberg, A. L.

“…Studies of many different rodent models of muscle wasting have indicated that accelerated proteolysis via the ubiquitin-proteasome pathway is the principal…”
Get full text

Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states by Lecker, S H, Solomon, V, Mitch, W E, Goldberg, A L

Get more information

Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy by Goldberg, A L

“…This review focuses on recent insights into the mechanisms and the biological functions of the proteasome. This large ATP-dependent proteolytic complex is the…”
Get more information

Proteasomes play an essential role in thymocyte apoptosis by Grimm, L. M., Goldberg, A. L., Poirier, G. G., Schwartz, L. M., Osborne, B. A.

“…Cell death in many different organisms requires the activation of proteolytic cascades involving cytosolic proteases. Here we describe a novel requirement in…”
Get full text

Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting by Wing, S.S, Goldberg, A.L

“…Glucocorticoids are essential for the increase in protein breakdown in skeletal muscle normally seen during fasting. To determine which proteolytic pathway(s)…”
Get full text

Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy by Medina, R, Wing, S S, Goldberg, A L

“…Most of the increased protein degradation in muscle atrophy caused by starvation and denervation is due to activation of a non-lysosomal ATP-dependent…”
Get full text

Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma by Baracos, V. E., DeVivo, C., Hoyle, D. H., Goldberg, A. L.

“…Rats implanted with Yoshida ascites hepatoma (YAH) show a rapid and selective loss of muscle protein due mainly to a marked increase (63-95%) in the rate of…”
Get full text

PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone by Goldberg, Alfred L, Benaroudj, Nadia

“…The proteasome-activating nucleotidase (PAN) from Methanococcus jannaschii is a complex of relative molecular mass 650,000 that is homologous to the ATPases in…”
Get full text

Functions of the Proteasome: The Lysis at the End of the Tunnel by Goldberg, Alfred L.

“…Most proteins in eukaryotic cells are degraded by a soluble, adenosine triphosphate (ATP)-dependent pathway present in both the nucleus and cytosol. This…”
Get full text

Proteolysis, proteasomes and antigen presentation by Goldberg, A. L., Rock, K. L.

“…Proteins presented to the immune system must first be cleaved to small peptides by intracellular proteinases. Proteasomes are proteolytic complexes that…”
Get full text

Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles by Tawa, Jr, N E, Odessey, R, Goldberg, A L

“…Several observations have suggested that the enhanced proteolysis and atrophy of skeletal muscle in various pathological states is due primarily to activation…”
Get full text

Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes by MITCH, W. E, MEDINA, R, GRIEBER, S, MAY, R. C, ENGLAND, B. K, PRICE, S. R, BAILEY, J. L, GOLDBERG, A. L

“…Metabolic acidosis often leads to loss of body protein due mainly to accelerated protein breakdown in muscle. To identify which proteolytic pathway is…”
Get full text

Protein degradation and protection against misfolded or damaged proteins by Goldberg, Alfred L

“…The ultimate mechanism that cells use to ensure the quality of intracellular proteins is the selective destruction of misfolded or damaged polypeptides. In…”
Get full text

γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes by Gaczynska, Maria, Rock, Kenneth L, Goldberg, Alfred L

“…The presentation of intracellular proteins to the immune system requires their degradation to small peptides that then become associated with major…”
Get full text

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins by DRISCOLL, J, GOLDBERG, A. L

“…Mammalian cells contain two large proteolytic complexes, the 650-kDa proteasome (or multicatalytic protease) and the 1500-kDa (26 S)…”
Get full text

Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats by Lecker, S. H., Solomon, V., Price, S. R., Kwon, Y. T., Mitch, W. E., Goldberg, A. L.

“…Insulin deficiency (e.g., in acute diabetes or fasting) is associated with enhanced protein breakdown in skeletal muscle leading to muscle wasting. Because…”
Get full text

The unfolding of substrates and ubiquitin-independent protein degradation by proteasomes by Benaroudj, N, Tarcsa, E, Cascio, P, Goldberg, A L

“…26S proteasomes are composed of a 20S proteolytic core and two ATPase-containing 19S regulatory particles. To clarify the role of these ATPases in proteolysis,…”
Get full text

The N-end Rule Pathway Catalyzes a Major Fraction of the Protein Degradation in Skeletal Muscle by Solomon, Vered, Lecker, Stewart H., Goldberg, Alfred L.

“…In skeletal muscle, overall protein degradation involves the ubiquitin-proteasome system. One property of a protein that leads to rapid ubiquitin-dependent…”
Get full text

Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation by Bhutani, N, Venkatraman, P, Goldberg, A L

“…Long stretches of glutamine (Q) residues are found in many cellular proteins. Expansion of these polyglutamine (polyQ) sequences is the underlying cause of…”
Get full text