Search Results - "Gold, P W"

The organization of the stress system and its dysregulation in depressive illness by Gold, P W

“…Stressors are imminent or perceived challenges to homeostasis. The stress response is an innate, stereotypic, adaptive response to stressors that has evolved…”
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Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-γ systems by Gold, P W, Licinio, J, Pavlatou, M G

“…Major depression and bipolar disorder are heterogeneous conditions in which there can be dysregulation of (1) the stress system response, (2) its capacity for…”
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Melancholic and atypical subtypes of depression represent distinct pathophysiological entities: CRH, neural circuits, and the diathesis for anxiety and depression by Gold, P W, Chrousos, G P

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Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states by GOLD, P. W, CHROUSOS, G. P

“…Stress precipitates depression and alters its natural history. Major depression and the stress response share similar phenomena, mediators and circuitries…”
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Acute ketamine administration corrects abnormal inflammatory bone markers in major depressive disorder by Kadriu, B, Gold, P W, Luckenbaugh, D A, Lener, M S, Ballard, E D, Niciu, M J, Henter, I D, Park, L T, De Sousa, R T, Yuan, P, Machado-Vieira, R, Zarate, C A

“…Patients with major depressive disorder (MDD) have clinically relevant, significant decreases in bone mineral density (BMD). We sought to determine if…”
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The role of adipokines in the rapid antidepressant effects of ketamine by Machado-Vieira, R, Gold, P W, Luckenbaugh, D A, Ballard, E D, Richards, E M, Henter, I D, De Sousa, R T, Niciu, M J, Yuan, P, Zarate, C A

“…We previously found that body mass index (BMI) strongly predicted response to ketamine. Adipokines have a key role in metabolism (including BMI). They directly…”
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Low early morning plasma cortisol in posttraumatic stress disorder is associated with co-morbid depression but not with enhanced glucocorticoid feedback inhibition by Vythilingam, M, Gill, J.M, Luckenbaugh, D.A, Gold, P.W, Collin, C, Bonne, O, Plumb, K, Polignano, E, West, K, Charney, D

“…Summary Background Co-morbid major depressive disorder (MDD) in individuals with posttraumatic stress disorder (PTSD) confers a more severe clinical course and…”
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Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls by HIROI, N, WONG, M. L, LICINIO, J, PARK, C, YOUNG, M, GOLD, P. W, CHROUSOS, G. P, BORNSTEIN, S. R

“…Corticotropin-releasing hormone (CRH) is a key neuroendocrine factor implementing endocrine, immune and behavioral responses to stress. CRH exerts its action…”
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Circadian interleukin-6 secretion and quantity and depth of sleep by VGONTZAS, A. N, PAPANICOLAOU, D. A, HERMIDA, R. C, MASTORAKOS, G, CHROUSOS, G. P, BIXLER, E. O, LOTSIKAS, A, ZACHMAN, K, KALES, A, PROLO, P, WONG, M.-L, LICINIO, J, GOLD, P. W

“…Patients with pathologically increased daytime sleepiness and fatigue have elevated levels of circulating interleukin-6 (IL-6). The latter is an inflammatory…”
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INDUCTION OF CORTICOTROPIN-RELEASING HORMONE GENE EXPRESSION BY GLUCOCORTICOIDS: IMPLICATION FOR UNDERSTANDING THE STATES OF FEAR AND ANXIETY AND ALLOSTATIC LOAD by Schulkin, Jay, W. Gold, Philip, S. McEwen, Bruce

“…Evidence supports the idea of two distinct corticotropin-releasing hormone (CRH) systems in the brain: one which is constrained by glucocorticoids and the…”
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Hypothalamic corticotropin-releasing hormone suppression during the postpartum period : Implications for the increase in psychiatric manifestations at this time by MAGIAKOU, M.-A, MASTORAKOS, G, RABIN, D, DUBBERT, B, GOLD, P. W, CHROUSOS, G. P

“…The third trimester of human pregnancy is characterized by a hyperactive hypothalamic-pituitary-adrenal axis, possibly driven by progressively increasing…”
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Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines by Papanicolaou, D A, Petrides, J S, Tsigos, C, Bina, S, Kalogeras, K T, Wilder, R, Gold, P W, Deuster, P A, Chrousos, G P

“…In experimental animals, stress and catecholamines stimulate endogenous interleukin-6 (IL-6) secretion, whereas glucocorticoids inhibit it. To examine whether…”
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Sleep deprivation effects on the activity of the hypothalamic-pituitary-adrenal and growth axes: potential clinical implications by Vgontzas, Alexandros N., Mastorakos, George, Bixler, Edward O., Kales, Anthony, Gold, Philip W., Chrousos, George P.

“…OBJECTIVES Although several studies have shown that sleep deprivation is associated with increased slow wave sleep during the recovery night, the effects of…”
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Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs by GABRY, K. E, CHROUSOS, G. P, RICE, K. C, MOSTAFA, R. M, STERNBERG, E, NEGRAO, A. B, WEBSTER, E. L, MCCANN, S. M, GOLD, P. W

“…When exposed to prolonged stress, rats develop gastric ulceration, enhanced colon motility with depletion of its mucin content and signs of physiological and…”
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Psychological stress increased corticotropin-releasing hormone mRNA and content in the central nucleus of the amygdala but not in the hypothalamic paraventricular nucleus in the rat by Makino, Shinya, Shibasaki, Tamotsu, Yamauchi, Naoko, Nishioka, Tatsuya, Mimoto, Tomoko, Wakabayashi, Ichiji, Gold, Philip W, Hashimoto, Kozo

“…The central administration of corticotropin-releasing hormone (CRH) to experimental animals sets into motion a coordinated series of physiological and…”
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Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression by Pavlatou, M G, Remaley, A T, Gold, P W

“…Klotho is a hormone secreted into human cerebrospinal fluid (CSF), plasma and urine that promotes longevity and influences the onset of several premature…”
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Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs by Gold, P W, Licinio, J, Wong, M L, Chrousos, G P

“…Hypercortisolism in depression seems to preferentially reflect activation of hypothalamic CRH secretion. Although it has been postulated that this…”
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Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women by Altemus, M, Deuster, P A, Galliven, E, Carter, C S, Gold, P W

“…In the rat, lactation suppresses a variety of physiological responses to stress. We investigated whether stress-responsive neurohormonal systems are also…”
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Inflammatory Mediator-Induced Hypothalamic-Pituitary-Adrenal Axis Activation is Defective in Streptococcal Cell Wall Arthritis-Susceptible Lewis Rats by Sternberg, Esther M., Hill, Joanna M., Chrousos, George P., Kamilaris, Themis, Listwak, Samuel J., Gold, Philip W., Wilder, Ronald L.

“…Inbred Lewis (LEW/N) female rats develop an arthritis in response to group A streptococcal cell wall peptidoglycan polysaccharide (SCW), which mimics human…”
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Differential hypothalamic-pituitary-adrenal axis reactivity to psychological and physical stress by SINGH, A, PETRIDES, J. S, GOLD, P. W, CHROUSOS, G. P, DEUSTER, P. A

“…Healthy men exhibit a differential hypothalamic-pituitary-adrenal axis (HPA) response to exercise stress and fall into two groups: high responders (HR) and low…”
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