Search Results - "Golani, Ofra"
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The human tumor microbiome is composed of tumor type-specific intracellular bacteria
Published in Science (American Association for the Advancement of Science) (29-05-2020)“…Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its…”
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Identification of bacteria-derived HLA-bound peptides in melanoma
Published in Nature (London) (01-04-2021)“…A variety of species of bacteria are known to colonize human tumours 1 – 11 , proliferate within them and modulate immune function, which ultimately affects…”
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Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer
Published in Nature communications (07-12-2020)“…In the colon, long-term exposure to chronic inflammation drives colitis-associated colon cancer (CAC) in patients with inflammatory bowel disease. While the…”
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High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function
Published in Gastroenterology (New York, N.Y. 1943) (01-11-2020)“…The intestinal barrier protects intestinal cells from microbes and antigens in the lumen—breaches can alter the composition of the intestinal microbiota, the…”
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Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients
Published in Nature communications (19-05-2022)“…The TP53 gene is mutated in approximately 60% of all colorectal cancer (CRC) cases. Over 20% of all TP53-mutated CRC tumors carry missense mutations at…”
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Global mRNA polarization regulates translation efficiency in the intestinal epithelium
Published in Science (American Association for the Advancement of Science) (22-09-2017)“…Asymmetric messenger RNA (mRNA) localization facilitates efficient translation in cells such as neurons and fibroblasts. However, the extent and importance of…”
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B cell dissemination patterns during the germinal center reaction revealed by whole-organ imaging
Published in The Journal of experimental medicine (04-11-2019)“…Germinal centers (GCs) are sites wherein B cells proliferate and mutate their immunoglobulins in the dark zone (DZ), followed by affinity-based selection in…”
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Thymic mimetic cells function beyond self-tolerance
Published in Nature (London) (05-10-2023)“…Development of immunocompetent T cells in the thymus is required for effective defence against all types of pathogens, including viruses, bacteria and fungi…”
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Bimodal magnetic resonance and optical imaging of extracellular matrix remodelling by orthotopic ovarian tumours
Published in British journal of cancer (21-07-2020)“…Background The extracellular matrix modulates the development of ovarian tumours. Currently, evaluation of the extracellular matrix in the ovary is limited to…”
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Egg multivesicular bodies elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilization
Published in Nature communications (08-07-2024)“…Mitochondria are maternally inherited, but the mechanisms underlying paternal mitochondrial elimination after fertilization are far less clear. Using…”
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Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments
Published in Cell reports (Cambridge) (17-01-2017)“…The endothelial cytoskeleton is a barrier for leukocyte transendothelial migration (TEM). Mononuclear and polymorphonuclear leukocytes generate gaps of similar…”
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The differential regulation of placenta trophoblast bisphosphoglycerate mutase in fetal growth restriction: preclinical study in mice and observational histological study of human placenta
Published in eLife (05-02-2024)“…Fetal growth restriction (FGR) is a pregnancy complication in which a newborn fails to achieve its growth potential, increasing the risk of perinatal morbidity…”
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Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration
Published in eLife (08-11-2019)“…In recent years, there has been increasing interest in the role of lymphatics in organ repair and regeneration, due to their importance in immune surveillance…”
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CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting
Published in Cell metabolism (14-06-2016)“…Signaling by the corticotropin-releasing factor receptor type 1 (CRFR1) plays an important role in mediating the autonomic response to stressful challenges…”
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Novel multimodal molecular imaging of Vitamin H (Biotin) transporter activity in the murine placenta
Published in Scientific reports (27-11-2020)“…Vitamin H (biotin) is delivered to the fetus transplacentally by an active biotin-transport mechanism and is critical for fetal development. Our objective was…”
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Author Correction: Novel multimodal molecular imaging of Vitamin H (Biotin) transporter activity in the murine placenta
Published in Scientific reports (15-03-2021)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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ICAM-1 on Breast Cancer Cells Suppresses Lung Metastasis but Is Dispensable for Tumor Growth and Killing by Cytotoxic T Cells
Published in Frontiers in immunology (11-07-2022)“…Breast tumors and their derived circulating cancer cells express the leukocyte β integrin ligand Intercellular adhesion molecule 1 (ICAM-1). We found that…”
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Highlights from the 2016-2020 NEUBIAS training schools for Bioimage Analysts: a success story and key asset for analysts and life scientists [version 1; peer review: 2 approved]
Published in F1000 research (2021)“…NEUBIAS, the European Network of Bioimage Analysts, was created in 2016 with the goal of improving the communication and the knowledge transfer among the…”
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Metabolic inputs in the probiotic bacterium Lacticaseibacillus rhamnosus contribute to cell-wall remodeling and increased fitness
Published in NPJ biofilms and microbiomes (26-09-2023)“…Lacticaseibacillus rhamnosus GG (LGG) is a Gram-positive beneficial bacterium that resides in the human intestinal tract and belongs to the family of lactic…”
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Unraveling the multifaceted resilience of arsenic resistant bacterium Deinococcus indicus
Published in Frontiers in microbiology (24-08-2023)“…Arsenic (As) is a toxic heavy metal widely found in the environment that severely undermines the integrity of water resources. Bioremediation of toxic…”
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