Search Results - "Goland, Robin"

Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation by Do, Catherine, Lang, Charles F., Lin, John, Darbary, Huferesh, Krupska, Izabela, Gaba, Aulona, Petukhova, Lynn, Vonsattel, Jean-Paul, Gallagher, Mary P., Goland, Robin S., Clynes, Raphael A., Dwork, Andrew, Kral, John G., Monk, Catherine, Christiano, Angela M., Tycko, Benjamin

“…Haplotype-dependent allele-specific methylation (hap-ASM) can impact disease susceptibility, but maps of this phenomenon using stringent criteria in…”
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Evidence of a Strong Association Between Frequency of Self-Monitoring of Blood Glucose and Hemoglobin A1c Levels in T1D Exchange Clinic Registry Participants by MILLER, Kellee M, BECK, Roy W, BERGENSTAL, Richard M, GOLAND, Robin S, HALLER, Michael J, MCGILL, Janet B, RODRIGUEZ, Henry, SIMMONS, Jill H, HIRSCH, Irl B

“…Despite substantial evidence of the benefit of frequent self-monitoring of blood glucose (SMBG) in type 1 diabetes, certain insurers limit the number of test…”
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Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos by Zuccaro, Michael V., Xu, Jia, Mitchell, Carl, Marin, Diego, Zimmerman, Raymond, Rana, Bhavini, Weinstein, Everett, King, Rebeca T., Palmerola, Katherine L., Smith, Morgan E., Tsang, Stephen H., Goland, Robin, Jasin, Maria, Lobo, Rogerio, Treff, Nathan, Egli, Dieter

“…Correction of disease-causing mutations in human embryos holds the potential to reduce the burden of inherited genetic disorders and improve fertility…”
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C-Peptide Levels in Subjects Followed Longitudinally Before and After Type 1 Diabetes Diagnosis in TrialNet by Bogun, Magdalena M, Bundy, Brian N, Goland, Robin S, Greenbaum, Carla J

“…Insulin secretion declines rapidly after diagnosis of type 1 diabetes, followed by a slower rate of change. Previous studies have demonstrated that the…”
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Prevalence of detectable C-Peptide according to age at diagnosis and duration of type 1 diabetes by Davis, Asa K, DuBose, Stephanie N, Haller, Michael J, Miller, Kellee M, DiMeglio, Linda A, Bethin, Kathleen E, Goland, Robin S, Greenberg, Ellen M, Liljenquist, David R, Ahmann, Andrew J, Marcovina, Santica M, Peters, Anne L, Beck, Roy W, Greenbaum, Carla J

“…It is generally accepted that complete β-cell destruction eventually occurs in individuals with type 1 diabetes, which has implications for treatment…”
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Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells by Yamada, Mitsutoshi, Johannesson, Bjarki, Sagi, Ido, Burnett, Lisa Cole, Kort, Daniel H., Prosser, Robert W., Paull, Daniel, Nestor, Michael W., Freeby, Matthew, Greenberg, Ellen, Goland, Robin S., Leibel, Rudolph L., Solomon, Susan L., Benvenisty, Nissim, Sauer, Mark V., Egli, Dieter

“…Here human embryonic stem cell lines are derived by somatic cell nuclear transfer from cells of a newborn and from skin cells of an adult, a female with type 1…”
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Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants by Paull, Daniel, Emmanuele, Valentina, Weiss, Keren A., Treff, Nathan, Stewart, Latoya, Hua, Haiqing, Zimmer, Matthew, Kahler, David J., Goland, Robin S., Noggle, Scott A., Prosser, Robert, Hirano, Michio, Sauer, Mark V., Egli, Dieter

“…Mitochondrial DNA mutations transmitted maternally within the oocyte cytoplasm often cause life-threatening disorders. Here we explore the use of nuclear…”
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Generation of pluripotent stem cells from patients with type 1 diabetes by Maehr, René, Chen, Shuibing, Snitow, Melinda, Ludwig, Thomas, Yagasaki, Lisa, Goland, Robin, Leibel, Rudolph L, Melton, Douglas A

“…Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic β cells. The cellular and molecular defects that cause the disease remain…”
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Pregnancy Outcomes in Youth With Type 2 Diabetes: The TODAY Study Experience by Klingensmith, Georgeanna J, Pyle, Laura, Nadeau, Kristen J, Barbour, Linda A, Goland, Robin S, Willi, Steven M, Linder, Barbara, White, Neil H

“…We evaluated pregnancy outcomes, maternal and fetal/neonatal, during the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study. The…”
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Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial by Orban, Tihamer, MD, Bundy, Brian, PhD, Becker, Dorothy J, Prof, DiMeglio, Linda A, MD, Gitelman, Stephen E, Prof, Goland, Robin, Prof, Gottlieb, Peter A, Prof, Greenbaum, Carla J, MD, Marks, Jennifer B, Prof, Monzavi, Roshanak, MD, Moran, Antoinette, Prof, Raskin, Philip, Prof, Rodriguez, Henry, Prof, Russell, William E, Prof, Schatz, Desmond, Prof, Wherrett, Diane, MD, Wilson, Darrell M, Prof, Krischer, Jeffrey P, Prof, Skyler, Jay S, Dr, Prof

“…Summary Background The immunopathogenesis of type 1 diabetes mellitus is associated with T-cell autoimmunity. To be fully active, immune T cells need a…”
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Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial by Russell, William E, Bundy, Brian N, Anderson, Mark S, Cooney, Laura A, Gitelman, Stephen E, Goland, Robin S, Gottlieb, Peter A, Greenbaum, Carla J, Haller, Michael J, Krischer, Jeffrey P, Libman, Ingrid M, Linsley, Peter S, Long, S Alice, Lord, Sandra M, Moore, Daniel J, Moore, Wayne V, Moran, Antoinette M, Muir, Andrew B, Raskin, Philip, Skyler, Jay S, Wentworth, John M, Wherrett, Diane K, Wilson, Darrell M, Ziegler, Anette-Gabriele, Herold, Kevan C

“…Previous studies showed that inhibiting lymphocyte costimulation reduces declining β-cell function in individuals newly diagnosed with type 1 diabetes. We…”
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Risk Factors Associated With Severe Hypoglycemia in Older Adults With Type 1 Diabetes by Weinstock, Ruth S, DuBose, Stephanie N, Bergenstal, Richard M, Chaytor, Naomi S, Peterson, Christina, Olson, Beth A, Munshi, Medha N, Perrin, Alysa J S, Miller, Kellee M, Beck, Roy W, Liljenquist, David R, Aleppo, Grazia, Buse, John B, Kruger, Davida, Bhargava, Anuj, Goland, Robin S, Edelen, Rachel C, Pratley, Richard E, Peters, Anne L, Rodriguez, Henry, Ahmann, Andrew J, Lock, John-Paul, Garg, Satish K, Rickels, Michael R, Hirsch, Irl B

“…Severe hypoglycemia is common in older adults with long-standing type 1 diabetes, but little is known about factors associated with its occurrence. A…”
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Glycemia reduction in type 2 diabetes—Hypoglycemia outcomes: A randomized clinical trial by Seaquist, Elizabeth R, Phillips, Lawrence S, Ghosh, Alokananda, Baker, Chelsea, Bergenstal, Richard M, Crandall, Jill P, Goland, Robin S, Gramzinski, Michaela R, Hox, Sophia H, Hsia, Daniel S, Johnson, Mary L, Lachin, John M, Raskin, Philip, Valencia, Willy M, Waltje, Andrea H, Younes, Naji, the GRADE Research Group

“…ObjectiveHypoglycemia is a major concern in type 2 diabetes (T2DM), but little is known about its likelihood compared across common therapies. We compared the…”
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Differentiation of hypothalamic-like neurons from human pluripotent stem cells by Wang, Liheng, Meece, Kana, Williams, Damian J, Lo, Kinyui Alice, Zimmer, Matthew, Heinrich, Garrett, Martin Carli, Jayne, Leduc, Charles A, Sun, Lei, Zeltser, Lori M, Freeby, Matthew, Goland, Robin, Tsang, Stephen H, Wardlaw, Sharon L, Egli, Dieter, Leibel, Rudolph L

“…The hypothalamus is the central regulator of systemic energy homeostasis, and its dysfunction can result in extreme body weight alterations. Insights into the…”
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Differences in the Management of Type 1 Diabetes Among Adults Under Excellent Control Compared With Those Under Poor Control in the T1D Exchange Clinic Registry by SIMMONS, Jill H, CHEN, Vincent, MILLER, Kellee M, MCGILL, Janet B, BERGENSTAL, Richard M, GOLAND, Robin S, HARLAN, David M, LARGAY, Joseph F, MASSARO, Elaine M, BECK, Roy W

“…Optimizing glycemic control in type 1 diabetes is important to minimize the risk of complications. We used the large T1D Exchange clinic registry database to…”
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Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial by Wherrett, Diane K, MD, Bundy, Brian, PhD, Becker, Dorothy J, Prof, DiMeglio, Linda A, MD, Gitelman, Stephen E, Prof, Goland, Robin, Prof, Gottlieb, Peter A, Prof, Greenbaum, Carla J, MD, Herold, Kevan C, Prof, Marks, Jennifer B, Prof, Monzavi, Roshanak, MD, Moran, Antoinette, Prof, Orban, Tihamer, MD, Palmer, Jerry P, MD, Raskin, Philip, Prof, Rodriguez, Henry, Prof, Schatz, Desmond, Prof, Wilson, Darrell M, Prof, Krischer, Jeffrey P, Prof, Skyler, Jay S, Dr, Prof

“…Summary Background Glutamic acid decarboxylase (GAD) is a major target of the autoimmune response that occurs in type 1 diabetes mellitus. In animal models of…”
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Recommendations for standardizing glucose reporting and analysis to optimize clinical decision making in diabetes: the Ambulatory Glucose Profile (AGP) by Bergenstal, Richard M, Ahmann, Andrew J, Bailey, Timothy, Beck, Roy W, Bissen, Joan, Buckingham, Bruce, Deeb, Larry, Dolin, Robert H, Garg, Satish K, Goland, Robin, Hirsch, Irl B, Klonoff, David C, Kruger, Davida F, Matfin, Glenn, Mazze, Roger S, Olson, Beth A, Parkin, Christopher, Peters, Anne, Powers, Margaret A, Rodriguez, Henry, Southerland, Phil, Strock, Ellie S, Tamborlane, William, Wesley, David M

“…Abstract Underutilization of glucose data and lack of easy and standardized glucose data collection, analysis, visualization, and guided clinical decision…”
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Distinct Imprinting Signatures and Biased Differentiation of Human Androgenetic and Parthenogenetic Embryonic Stem Cells by Sagi, Ido, De Pinho, Joao C., Zuccaro, Michael V., Atzmon, Chen, Golan-Lev, Tamar, Yanuka, Ofra, Prosser, Robert, Sadowy, Alexandra, Perez, Gloria, Cabral, Thiago, Glaser, Benjamin, Tsang, Stephen H., Goland, Robin, Sauer, Mark V., Lobo, Rogerio, Benvenisty, Nissim, Egli, Dieter

“…Genomic imprinting is an epigenetic mechanism that results in parent-of-origin monoallelic expression of specific genes, which precludes uniparental…”
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A model for personalized in vivo analysis of human immune responsiveness by Kalscheuer, Hannes, Danzl, Nichole, Onoe, Takashi, Faust, Ted, Winchester, Robert, Goland, Robin, Greenberg, Ellen, Spitzer, Thomas R, Savage, David G, Tahara, Hiroyuki, Choi, Goda, Yang, Yong-Guang, Sykes, Megan

“…Studies of human immune diseases are generally limited to the analysis of peripheral blood lymphocytes of heterogeneous patient populations. Improved models…”
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Glycemia Treatment Strategies in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial by Gerstein, Hertzel C., MD, MSc, Riddle, Matthew C., MD, Kendall, David M., MD, Cohen, Robert M., MD, Goland, Robin, MD, Feinglos, Mark N., MD, CM, Kirk, Julienne K., PharmD, CDE, Hamilton, Bruce P., MD, Ismail-Beigi, Faramarz, MD, PhD, Feeney, Patricia, MS, MA

“…There is an independent progressive epidemiologic relation between glycemia and cardiovascular disease (CVD) events; however, whether lowering glucose levels…”
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