Search Results - "Gola, Anita"

Environmental control of lineage plasticity and stem cell memory by Gola, Anita, Fuchs, Elaine

“…Tissue-resident stem cells (SCs) are critical players in the maintenance of tissue homeostasis. SCs reside in complex and uniquely anatomically organized…”
Get full text

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis by Seidman, Jason S., Troutman, Ty D., Sakai, Mashito, Gola, Anita, Spann, Nathanael J., Bennett, Hunter, Bruni, Cassi M., Ouyang, Zhengyu, Li, Rick Z., Sun, Xiaoli, Vu, BaoChau T., Pasillas, Martina P., Ego, Kaori M., Gosselin, David, Link, Verena M., Chong, Ling-Wa, Evans, Ronald M., Thompson, Bonne M., McDonald, Jeffrey G., Hosseini, Mojgan, Witztum, Joseph L., Germain, Ronald N., Glass, Christopher K.

“…Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues,…”
Get full text

IBEX: A versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues by Radtke, Andrea J, Kandov, Evelyn, Lowekamp, Bradley, Speranza, Emily, Chu, Colin J, Gola, Anita, Thakur, Nishant, Shih, Rochelle, Yao, Li, Yaniv, Ziv Rafael, Beuschel, Rebecca T, Kabat, Juraj, Croteau, Joshua, Davis, Jeremy, Hernandez, Jonathan M, Germain, Ronald N

“…The diverse composition of mammalian tissues poses challenges for understanding the cell-cell interactions required for organ homeostasis and how spatial…”
Get full text

Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories by Gonzales, Kevin Andrew Uy, Polak, Lisa, Matos, Irina, Tierney, Matthew T, Gola, Anita, Wong, Ellen, Infarinato, Nicole R, Nikolova, Maria, Luo, Shijing, Liu, Siqi, Novak, Jesse S S, Lay, Kenneth, Pasolli, Hilda Amalia, Fuchs, Elaine

“…Immune and tissue stem cells retain an epigenetic memory of inflammation that intensifies sensitivity to future encounters. We investigated whether and to what…”
Get full text

Prime and target immunization protects against liver-stage malaria in mice by Gola, Anita, Silman, Daniel, Walters, Adam A, Sridhar, Saranya, Uderhardt, Stefan, Salman, Ahmed M, Halbroth, Benedict R, Bellamy, Duncan, Bowyer, Georgina, Powlson, Jonathan, Baker, Megan, Venkatraman, Navin, Poulton, Ian, Berrie, Eleanor, Roberts, Rachel, Lawrie, Alison M, Angus, Brian, Khan, Shahid M, Janse, Chris J, Ewer, Katie J, Germain, Ronald N, Spencer, Alexandra J, Hill, Adrian V S

“…Despite recent advances in treatment and vector control, malaria is still a leading cause of death, emphasizing the need for an effective vaccine. The malaria…”
Get more information

The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via β2 integrins (CD11/CD18) by Weckbach, Ludwig T., Gola, Anita, Winkelmann, Michael, Jakob, Sascha M., Groesser, Leopold, Borgolte, Julia, Pogoda, Frank, Pick, Robert, Pruenster, Monika, Müller-Höcker, Josef, Deindl, Elisabeth, Sperandio, Markus, Walzog, Barbara

“…Emerging evidence suggests a role of the cytokine midkine (MK) in inflammation. In this study, its functional relevance for recruitment of polymorphonuclear…”
Get full text

The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress by Hurwitz, Brian, Guzzi, Nicola, Gola, Anita, Fiore, Vincent F, Sendoel, Ataman, Nikolova, Maria, Barrows, Douglas, Carroll, Thomas S, Pasolli, H Amalia, Fuchs, Elaine

“…Cells encountering stressful situations activate the integrated stress response (ISR) pathway to limit protein synthesis and redirect translation to better…”
Get full text

Preclinical Development and Assessment of Viral Vectors Expressing a Fusion Antigen of Plasmodium falciparum LSA1 and LSAP2 for Efficacy against Liver-Stage Malaria by Halbroth, Benedict R, Sebastian, Sarah, Salman, Ahmed M, Ulaszewska, Marta, Gola, Anita, Longley, Rhea J, Janse, Chris J, Khan, Shahid M, Hill, Adrian V S, Spencer, Alexandra J

“…Despite promising progress in malaria vaccine development in recent years, an efficacious subunit vaccine against remains to be licensed and deployed…”
Get full text

Designer bugs as cancer drugs? by Sajjath, Sairaj M, Gola, Anita, Fuchs, Elaine

“…Skin microbiota can be engineered to induce antitumor T cells…”
Get full text

Commensal-driven immune zonation of the liver promotes host defence by Gola, Anita, Dorrington, Michael G., Speranza, Emily, Sala, Claudia, Shih, Rochelle M., Radtke, Andrea J., Wong, Harikesh S., Baptista, Antonio P., Hernandez, Jonathan M., Castellani, Gastone, Fraser, Iain D. C., Germain, Ronald N.

“…The liver connects the intestinal portal vasculature with the general circulation, using a diverse array of immune cells to protect from pathogens that…”
Get full text

A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells by Wong, Harikesh S., Park, Kyemyung, Gola, Anita, Baptista, Antonio P., Miller, Christine H., Deep, Deeksha, Lou, Meng, Boyd, Lisa F., Rudensky, Alexander Y., Savage, Peter A., Altan-Bonnet, Grégoire, Tsang, John S., Germain, Ronald N.

“…A fraction of mature T cells can be activated by peripheral self-antigens, potentially eliciting host autoimmunity. We investigated homeostatic control of…”
Get full text

The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity by Baptista, Antonio P., Gola, Anita, Huang, Yuefeng, Milanez-Almeida, Pedro, Torabi-Parizi, Parizad, Urban, Joseph F., Shapiro, Virginia S., Gerner, Michael Y., Germain, Ronald N.

“…Lymph nodes (LNs) play critical roles in adaptive immunity by concentrating in one location the antigens, antigen-presenting cells, and antigen-responsive…”
Get full text

IBEX: an iterative immunolabeling and chemical bleaching method for high-content imaging of diverse tissues by Radtke, Andrea J., Chu, Colin J., Yaniv, Ziv, Yao, Li, Marr, James, Beuschel, Rebecca T., Ichise, Hiroshi, Gola, Anita, Kabat, Juraj, Lowekamp, Bradley, Speranza, Emily, Croteau, Joshua, Thakur, Nishant, Jonigk, Danny, Davis, Jeremy L., Hernandez, Jonathan M., Germain, Ronald N.

“…High-content imaging is needed to catalog the variety of cellular phenotypes and multicellular ecosystems present in metazoan tissues. We recently developed…”
Get full text

System control of auto-reactive T cells by Wong, Harikesh S., Gola, Anita, Angermann, Bastian, Germain, Ronald N.

“…Abstract Potentially auto-reactive T cells routinely escape thymic negative selection, but rarely elicit peripheral autoimmunity. We investigated the fate of…”
Get full text

Stem cells tightly regulate dead cell clearance to maintain tissue fitness by Stewart, Katherine S, Abdusselamoglu, Merve Deniz, Tierney, Matthew T, Gola, Anita, Hur, Yun Ha, Gonzales, Kevin A U, Yuan, Shaopeng, Bonny, Alain R, Yang, Yihao, Infarinato, Nicole R, Cowley, Christopher J, Levorse, John M, Pasolli, Hilda Amalia, Ghosh, Sourav, Rothlin, Carla V, Fuchs, Elaine

“…Billions of cells are eliminated daily from our bodies14. Although macrophages and dendritic cells are dedicated to migrating and engulfing dying cells and…”
Get full text

Stem cells tightly regulate dead cell clearance to maintain tissue fitness by Stewart, Katherine S., Abdusselamoglu, Merve Deniz, Tierney, Matthew T., Gola, Anita, Hur, Yun Ha, Gonzales, Kevin A. U., Yuan, Shaopeng, Bonny, Alain R., Yang, Yihao, Infarinato, Nicole R., Cowley, Christopher J., Levorse, John M., Pasolli, Hilda Amalia, Ghosh, Sourav, Rothlin, Carla V., Fuchs, Elaine

“…Billions of cells are eliminated daily from our bodies 1 – 4 . Although macrophages and dendritic cells are dedicated to migrating and engulfing dying cells…”
Get full text

Author Correction: Commensal-driven immune zonation of the liver promotes host defence by Gola, Anita, Dorrington, Michael G., Speranza, Emily, Sala, Claudia, Shih, Rochelle M., Radtke, Andrea J., Wong, Harikesh S., Baptista, Antonio P., Hernandez, Jonathan M., Castellani, Gastone, Fraser, Iain D. C., Germain, Ronald N.

Get full text

IBEX: A versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues by Radtke, Andrea J., Kandov, Evelyn, Lowekamp, Bradley, Speranza, Emily, Chu, Colin J., Gola, Anita, Thakur, Nishant, Shih, Rochelle, Yao, Li, Yaniv, Ziv Rafael, Beuschel, Rebecca T., Kabat, Juraj, Croteau, Joshua, Davis, Jeremy, Hernandez, Jonathan M., Germain, Ronald N.

“…The diverse composition of mammalian tissues poses challenges for understanding the cell–cell interactions required for organ homeostasis and how spatial…”
Get full text

Author Correction: Commensal-driven immune zonation of the liver promotes host defence by Gola, Anita, Dorrington, Michael G., Speranza, Emily, Sala, Claudia, Shih, Rochelle M., Radtke, Andrea J., Wong, Harikesh S., Baptista, Antonio P., Hernandez, Jonathan M., Castellani, Gastone, Fraser, Iain D. C., Germain, Ronald N.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41586-021-03346-0…”
Get full text

The role of antigen in the maintenance and localisation of cd8+ t-cells in the context of liver stage malaria by Gola, Anita

“…A highly effective vaccine against malaria is urgently needed, with leading vaccination strategies involving the induction of protective antigen-specific CD8+…”
Get full text