Search Results - "Gokhale, Vijay M"

Discovery of a novel class of AKT pleckstrin homology domain inhibitors by Mahadevan, Daruka, Powis, Garth, Mash, Eugene A, George, Benjamin, Gokhale, Vijay M, Zhang, Shuxing, Shakalya, Kishore, Du-Cuny, Lei, Berggren, Margareta, Ali, M Ahad, Jana, Umasish, Ihle, Nathan, Moses, Sylvestor, Franklin, Chloe, Narayan, Satya, Shirahatti, Nikhil, Meuillet, Emmanuelle J

“…AKT, a phospholipid-binding serine/threonine kinase, is a key component of the phosphoinositide 3-kinase cell survival signaling pathway that is aberrantly…”
Get full text

Identification of a novel inhibitor of urokinase-type plasminogen activator by Zhu, Ming, Gokhale, Vijay M, Szabo, Lajos, Munoz, Ruben M, Baek, Hyounggee, Bashyam, Sridevi, Hurley, Laurence H, Von Hoff, Daniel D, Han, Haiyong

“…Urokinase-type plasminogen activator (uPA), a highly restricted serine protease, plays an important role in the regulation of diverse physiologic and…”
Get full text

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1 by Dexheimer, Thomas S., Carey, Steven S., Zuohe, Song, Gokhale, Vijay M., Hu, Xiaohui, Murata, Lauren B., Maes, Estelle M., Weichsel, Andrzej, Sun, Daekyu, Meuillet, Emmanuelle J., Montfort, William R., Hurley, Laurence H.

“…The formation of G-quadruplex structures within the nuclease hypersensitive element (NHE) III 1 region of the c-myc promoter and the ability of these…”
Get full text

Understanding the antifungal activity of terbinafine analogues using quantitative structure–activity relationship (qsar) models by Gokhale, Vijay M, Kulkarni, Vithal M

“…Terbinafine and its analogues, which are a major class of non-azole antifungal agents, are known to act by inhibition of squalene epoxidase enzyme in fungal…”
Get full text

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1) by Dexheimer, Thomas S, Carey, Steven S, Zuohe, Song, Gokhale, Vijay M, Hu, Xiaohui, Murata, Lauren B, Maes, Estelle M, Weichsel, Andrzej, Sun, Daekyu, Meuillet, Emmanuelle J, Montfort, William R, Hurley, Laurence H

“…The formation of G-quadruplex structures within the nuclease hypersensitive element (NHE) III(1) region of the c-myc promoter and the ability of these…”
Get full text

Comparative Molecular Field Analysis of Fungal Squalene Epoxidase Inhibitors by Gokhale, Vijay M, Kulkarni, Vithal M

“…Comparative molecular field analysis (CoMFA) of fungal squalene epoxidase inhibitors exhibiting antifungal activity reported in terms of minimum inhibitory…”
Get full text

Selectivity analysis of 5-(arylthio)-2,4-diaminoquinazolines as inhibitors of Candida albicans dihydrofolate reductase by molecular dynamics simulations by Gokhale, V M, Kulkarni, V M

“…A series of 5-(arylthio)-2,4-diaminoquinazolines are known as selective inhibitors of dihydrofolate reductase (DHFR) from Candida albicans. We have performed…”
Get full text

While NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression, it does not cleave the NHE III1 element by Dexheimer, Thomas S., Carey, Steven S., Zuohe, Song, Gokhale, Vijay M., Hu, Xiaohui, Murata, Lauren B., Maes, Estelle M., Weichsel, Andrzej, Sun, Daekyu, Meuillet, Emmanuelle J., Montfort, William R., Hurley, Laurence H.

“…The formation of G-quadruplex structures within the NHE III 1 region of the c-myc promoter and the ability of these structures to repress c-myc transcription…”
Get full text