Galectin-3 levels and inflammatory response in patients undergoing bariatric surgery

Galectin-3 levels and inflammatory response in patients undergoing bariatric surgery

•Obesity is a state of chronic low-grade inflammation.•Significant changes to varying degrees have been detected in inflammatory marker levels in obese individuals.•Gal-3 is increased in morbid obese subjects and found a relation with body mass index, inflammatory markers and insulin resistance.•Gal...

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Published in:Cytokine (Philadelphia, Pa.) Vol. 151; p. 155793
Main Authors: Zeytinli Aksit, Merve, Demet Arslan, Fatma, Karakoyun, Inanc, Aydin, Cengiz, Turgut, Emre, Parildar, Hulya, Gokbalci, Umut, Isbilen Basok, Banu, Duman, Can, Emiroglu, Mustafa
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-03-2022
Subjects:
Adiponectin
Bariatric Surgery
Blood Proteins
Galectin 3
Galectins - blood
Humans
Inflammation
Insulin
Insulin resistance
Insulin Resistance - physiology
Leptin
Obesity
Obesity
Insulin resistance
Inflammation
Galectin-3
Bariatric surgery
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Summary:•Obesity is a state of chronic low-grade inflammation.•Significant changes to varying degrees have been detected in inflammatory marker levels in obese individuals.•Gal-3 is increased in morbid obese subjects and found a relation with body mass index, inflammatory markers and insulin resistance.•Gal-3 may play a role on inflammation-induced insulin resistance in obese subjects.•The weight loss caused by bariatric surgery significantly improves the inflammatory status and insulin resistance. Obesity, a low-grade systemic inflammatory disease, causes inflammation in metabolic tissues. Galectin-3(Gal-3) is one of the lectin molecules involved in inflammatory processes. We evaluated the possible relationship between Gal-3 level and the metabolic inflammatory process before and after obesity surgery. One hundred participants were included in the study and classified as normal weight, overweight, Class I, II, and III obese. Class III obese group underwent bariatric surgery and evaluated in the 3rd and 6th months after surgery. Glucose, insulin, glycated hemoglobin A1c (HbA1c), homeostatic model assessment of insulin resistance (HOMA-IR), high sensitivity C-reactive protein (hsCRP), Gal-3, interleukin (IL)-6, IL-10, adiponectin, and leptin levels were determined. Gal-3 levels were higher in Class III obese compared to the normal weight group. Postoperative leptin and hsCRP levels were decreased significantly, but the decrease in IL-6 and Gal-3 levels were not significant. Postoperative increased adiponectin and IL-10 levels were significant. Gal-3 was found significantly higher in insulin resistant group. The correlation between Gal-3 with BMI, adiponectin, leptin, hsCRP levels, and HOMA-IR was found weak. These findings might support the fact that Gal-3 is one of the molecules involved in the linkage between insulin resistance and meta-inflammation in morbid obese.
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ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2022.155793