Search Results - "Gois, Pedro M. P"

Boronic Acids and Esters in the Petasis-Borono Mannich Multicomponent Reaction by Candeias, Nuno R, Montalbano, Francesco, Cal, Pedro M. S. D, Gois, Pedro M. P

“…An examination of chemical reactions involving boronic acids, amines and aldehydes is presented. The Petasis-Borono Mannich multicomponent reaction is a…”
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Construction of homogeneous antibody-drug conjugates using site-selective protein chemistry by Akkapeddi, Padma, Azizi, Saara-Anne, Freedy, Allyson M, Cal, Pedro M. S. D, Gois, Pedro M. P, Bernardes, Gonçalo J. L

“…Systemic chemotherapy, the current standard of care for the treatment of cancer, is rarely curative and is often accompanied by debilitating side effects…”
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Iminoboronates: A New Strategy for Reversible Protein Modification by Cal, Pedro M. S. D, Vicente, João B, Pires, Elisabete, Coelho, Ana V, Veiros, Luı́s F, Cordeiro, Carlos, Gois, Pedro M. P

“…Protein modification has entered the limelight of chemical and biological sciences, since, by appending small molecules into proteins surfaces, fundamental…”
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Circularly Polarized Luminescence of Boronic Acid-Derived Salicylidenehydrazone Complexes Containing Chiral Boron as Stereogenic Unit by Jiménez, Vicente G, Santos, Fábio M. F, Castro-Fernández, Silvia, Cuerva, Juan M, Gois, Pedro M. P, Pischel, Uwe, Campaña, Araceli G

“…Racemic mixtures of boronic acid-derived salicylidenehydrazone (BASHY) complexes were enantiomerically resolved. The chiroptical properties of the…”
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Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation by Ferreira Faustino, Hélio Manuel, Silva, Maria J.S.A., Veiros, Luis Filipe, Bernardes, Gonçalo, Gois, Pedro

“…This journal is © The Royal Society of Chemistry 2016. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence We show that formyl…”
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Homologation Reaction of Ketones with Diazo Compounds by Candeias, Nuno R, Paterna, Roberta, Gois, Pedro M. P

“…This review covers the addition of diazo compounds to ketones to afford homologated ketones, either in the presence or in the absence of promoters or…”
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Rabbit derived VL single-domains as promising scaffolds to generate antibody–drug conjugates by André, Ana S., Dias, Joana N. R., Aguiar, Sandra, Nogueira, Sara, Bule, Pedro, Carvalho, Joana Inês, António, João P. M., Cavaco, Marco, Neves, Vera, Oliveira, Soraia, Vicente, Gonçalo, Carrapiço, Belmira, Braz, Berta São, Rütgen, Barbara, Gano, Lurdes, Correia, João D. G., Castanho, Miguel, Goncalves, Joao, Gois, Pedro M. P., Gil, Solange, Tavares, Luís, Aires-da-Silva, Frederico

“…Antibody–drug conjugates (ADCs) are among the fastest-growing classes of therapeutics in oncology. Although ADCs are in the spotlight, they still present…”
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A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes) by Santos, Fábio M. F., Rosa, João N., Candeias, Nuno R., Carvalho, Cátia Parente, Matos, Ana I., Ventura, Ana E., Florindo, Helena F., Silva, Liana C., Pischel, Uwe, Gois, Pedro M. P.

“…The modular assembly of boronic acids with Schiff‐base ligands enabled the construction of innovative fluorescent dyes [boronic acid salicylidenehydrazone…”
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Boronic acids as building blocks for the construction of therapeutically useful bioconjugates by António, João P M, Russo, Roberto, Carvalho, Cátia Parente, Cal, Pedro M S D, Gois, Pedro M P

“…Bioconjugates are multifunctional constructs in which biomolecules like peptides, proteins, vitamins and nucleic acids are endowed with the properties of…”
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NHC−Iron-Catalyzed Aerobic Oxidative Aromatic Esterification of Aldehydes using Boronic Acids by Rosa, João N, Reddy, R. Sudarshan, Candeias, Nuno R, Cal, Pedro M. S. D, Gois, Pedro M. P

“…NHC−iron complexes prepared in situ very efficiently afforded benzoates via the aerobic oxidative aromatic esterification of aldehydes with boronic acids. This…”
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Reversible Lysine Modification on Proteins by Using Functionalized Boronic Acids by Cal, Pedro M. S. D., Frade, Raquel F. M., Cordeiro, Carlos, Gois, Pedro M. P.

“…Iminoboronates have been utilized to successfully install azide and alkyne bioorthogonal functions on proteins, which may then be further reacted with their…”
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Diazaborines as New Inhibitors of Human Neutrophil Elastase by António, João P. M, Gonçalves, Lídia M, Guedes, Rita C, Moreira, Rui, Gois, Pedro M. P

“…Boronic acids (BAs) are a prominent functionality extensively used to design biologically active compounds and functional biomaterials. Boronic acids open…”
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Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells by Cal, Pedro M S D, Sieglitz, Florian, Santos, Fábio M F, Parente Carvalho, Cátia, Guerreiro, Ana, Bertoldo, Jean B, Pischel, Uwe, Gois, Pedro M P, Bernardes, Gonçalo J L

“…Fluorophores are indispensable for imaging biological processes. We report the design and synthesis of azide-tagged boronic acid salicylidenehydrazone (BASHY)…”
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Axial Coordination of NHC Ligands on Dirhodium(II) Complexes: Generation of a New Family of Catalysts by Trindade, Alexandre F, Gois, Pedro M. P, Veiros, Luís F, André, Vânia, Duarte, M. Teresa, Afonso, Carlos A. M, Caddick, Stephen, Cloke, F. Geoffrey N

“…An efficient new methodology for the arylation of aldehydes is disclosed which uses dirhodium(II) catalysts and N-heterocyclic carbene (NHC) ligands. Complexes…”
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Rh(II)-Catalyzed Intramolecular C−H Insertion of Diazo Substrates in Water:  Scope and Limitations by Candeias, Nuno R, Gois, Pedro M. P, Afonso, Carlos A. M

“…Preferential Rh(II) carbenoid intramolecular C−H versus O−H insertion derived from α-diazo-acetamides can be achieved in water by using an appropriate…”
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A Sustainable Protocol for the Aqueous Multicomponent Petasis Borono–Mannich Reaction by Candeias, Nuno R, Paterna, Roberta, Cal, Pedro M. S. D, Góis, Pedro M. P

“…A protocol for the preparation of Petasis borono–Mannich products suitable for advanced organic chemistry experiments, using water as a reaction medium, was…”
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Dual Stimuli-Responsive Dynamic Covalent Peptide Tags: Toward Sequence-Controlled Release in Tumor-like Microenvironments by Zegota, Maksymilian Marek, Müller, Michael Andreas, Lantzberg, Bellinda, Kizilsavas, Gönül, Coelho, Jaime A. S, Moscariello, Pierpaolo, Martínez-Negro, María, Morsbach, Svenja, Gois, Pedro M. P, Wagner, Manfred, Ng, David Y. W, Kuan, Seah Ling, Weil, Tanja

“…Dynamic covalent chemistry (DCvC) has emerged as a versatile synthetic tool for devising stable, stimuli-responsive linkers or conjugates. The interplay of…”
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Recyclable Stereoselective Catalysts by Trindade, Alexandre F, Gois, Pedro M. P, Afonso, Carlos A. M

“…Recent research on recyclable stereoselection catalysts is examined. The focus of the research is asymmetric alkene hydrogenation of heterogeneous catalysts,…”
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More Sustainable Approaches for the Synthesis of N-Based Heterocycles by Candeias, Nuno R, Branco, Luís C, Gois, Pedro M. P, Afonso, Carlos A. M, Trindade, Alexandre F

“…Sustainable approaches for the synthesis of N-based heterocycles are examined. Many methods for the synthesis of N-based heterocycles are based on solvent free…”
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Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes by Hebel, Marco, Riegger, Andreas, Zegota, Maksymilian M, Kizilsavas, Gönül, Gačanin, Jasmina, Pieszka, Michaela, Lückerath, Thorsten, Coelho, Jaime A. S, Wagner, Manfred, Gois, Pedro M. P, Ng, David Y. W, Weil, Tanja

“…The development of a synthetic code that enables a sequence programmable feature like DNA represents a key aspect toward intelligent molecular systems. We…”
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