Search Results - "Goins, W F"

Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-β peptide in vivo by HONG, C.-S, GOINS, W. F, GOSS, J. R, BURTON, E. A, GLORIOSO, J. C

“…Accumulation of insoluble aggregates of amyloid-beta peptide (Abeta), a cleavage product of amyloid precursor protein (APP), is thought to be central to the…”
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Relief of pain induced by varicella-zoster virus in a rat model of post-herpetic neuralgia using a herpes simplex virus vector expressing enkephalin by Guedon, J-M G, Zhang, M, Glorioso, J C, Goins, W F, Kinchington, P R

“…Acute and chronic pain (post-herpetic neuralgia or PHN) are encountered in patients with herpes zoster that is caused by reactivation of varicella-zoster virus…”
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Effect of herpes simplex virus vector-mediated interleukin-4 gene therapy on bladder overactivity and nociception by Oguchi, T, Funahashi, Y, Yokoyama, H, Nishizawa, O, Goins, W F, Goss, J R, Glorioso, J C, Yoshimura, N

“…We investigated the effects of replication-defective herpes simplex virus (HSV) vector expression of interleukin-4 (IL-4) on bladder overactivity and…”
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Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV by Wang, P-Y, Currier, M A, Hansford, L, Kaplan, D, Chiocca, E A, Uchida, H, Goins, W F, Cohen, J B, Glorioso, J C, van Kuppevelt, T H, Mo, X, Cripe, T P

“…Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disease (LPD) after hematopoietic stem cell or solid organ transplantation remains a…”
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Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion by GOSS, J. R, MATA, M, GOINS, W. F, WU, H. H, GLORIOSO, J. C, FINK, D. J

“…Endogenous opiate peptides acting pre- and post-synaptically in the dorsal horn of spinal cord inhibit transmission of nociceptive stimuli. We transfected…”
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Herpes simplex virus vector-mediated gene delivery of glutamic acid decarboxylase reduces detrusor overactivity in spinal cord-injured rats by Miyazato, M, Sugaya, K, Goins, W F, Wolfe, D, Goss, J R, Chancellor, M B, de Groat, W C, Glorioso, J C, Yoshimura, N

“…We examined whether replication-defective herpes simplex virus (HSV) vectors encoding the 67 kDa form of the glutamic acid decarboxylase (GAD 67 ) gene…”
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Quantification of HSV-1-mediated expression of the ferritin MRI reporter in the mouse brain by Iordanova, B, Goins, W F, Clawson, D S, Hitchens, T K, Ahrens, E T

“…The development of effective strategies for gene therapy has been hampered by difficulties verifying transgene delivery in vivo and quantifying gene expression…”
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HSV trafficking and development of gene therapy vectors with applications in the nervous system by Frampton, Jr, A R, Goins, W F, Nakano, K, Burton, E A, Glorioso, J C

“…Herpes simplex virus type 1 (HSV-1) is a neurotropic double-stranded DNA virus that causes cold sores, keratitis, and rarely encephalitis in humans…”
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Herpes simplex virus vector-mediated gene delivery for the treatment of lower urinary tract pain by Goins, W F, Goss, J R, Chancellor, M B, de Groat, W C, Glorioso, J C, Yoshimura, N

“…Interstitial cystitis (IC)/painful bladder syndrome (PBS) is a painful debilitating chronic visceral pain disorder of unknown etiology that affects an…”
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Gene transfer to neurons using herpes simplex virus-based vectors by FINK, D. J, DELUCA, N. A, GOINS, W. F, GLORIOSO, J. C

“…One important outgrowth of molecular medicine is the development of technologies for the transfer of therapeutic genes to cells in culture and tissues in vivo,…”
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A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats by GOINS, W. F, STERNBERG, L. R, CROEN, K. D, HENDRICKS, R. L, FINK, D. J, STRAUS, S. E, LEVINE, M, GLORIOSO, J. C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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HSV vector-mediated transduction and GDNF secretion from adipose cells by FRADETTE, J, WOLFE, D, GOINS, W. F, HUANG, S, FLANIGAN, R. M, GLORIOSO, J. C

“…The accessibility of adipose tissue and its ability to secrete various bioactive molecules suggest that adipose cells may be attractive targets for gene…”
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Engineering Herpes Simplex Virus Vectors for CNS Applications by Wolfe, D., Goins, W.F., Yamada, M., Moriuchi, S., Krisky, D.M., Oligino, T.J., Marconi, P.C., Fink, D.J., Glorioso, J.C.

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Herpes simplex virus vector-mediated delivery of glial cell line-derived neurotrophic factor rescues erectile dysfunction following cavernous nerve injury by KATO, R, WOLFE, D, CHANCELLOR, M. B, YOSHIMURA, N, COYLE, C. H, HUANG, S, WECHUCK, J. B, GOINS, W. F, KRISKY, D. M, TSUKAMOTO, T, NELSON, J. B, GLORIOSO, J. C

“…Erectile dysfunction (ED) is frequently associated with injury to the cavernous nerve sustained during pelvic surgery. Functional recovery from cavernous nerve…”
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Antihyperalgesic Effects of Infection with a Preproenkephalin-Encoding Herpes Virus by Wilson, Steven P., Yeomans, David C., Bender, Mary Ann, Lu, Ying, Goins, William F., Glorioso, Joseph C.

“…To test the utility of gene therapeutic approaches for the treatment of pain, a recombinant herpes simplex virus, type 1, has been engineered to contain the…”
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Effects of herpes simplex virus vectors encoding poreless TRPV1 or protein phosphatase 1α in a rat cystitis model induced by hydrogen peroxide by Takai, S, Majima, T, Reinhart, B, Goins, W F, Funahashi, Y, Gotoh, M, Tyagi, P, Glorioso, J C, Yoshimura, N

“…Enhanced afferent excitability is considered to be an important pathophysiological basis of interstitial cystitis/bladder pain syndrome (IC/BPS). In addition,…”
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MnSOD mediated by HSV vectors in the periaqueductal gray suppresses morphine withdrawal in rats by Iida, T, Yi, H, Liu, S, Ikegami, D, Zheng, W, Liu, Q, Takahashi, K, Kashiwagi, Y, Goins, W F, Glorioso, J C, Hao, S

“…Morphine appears to be the most active metabolite of heroin; therefore, the effects of morphine are important in understanding the ramifications of heroin…”
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A new transgene reporter for in vivo magnetic resonance imaging by Ahrens, Eric T, Genove, Guillem, DeMarco, Ulrike, Xu, Hongyan, Goins, William F

“…We report a new platform technology for visualizing transgene expression in living subjects using magnetic resonance imaging (MRI). Using a vector, we…”
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Deletion of multiple immediate-early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons by KRISKY, D. M, WOLFE, D, GOINS, W. F, MARCONI, P. C, RAMAKRISHNAN, R, MATA, M, ROUSE, R. J. D, FINK, D. J, GLORIOSO, J. C

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Promoter-Regulatory Region of the Major Immediate Early Gene of Human Cytomegalovirus by Thomsen, Darrell R., Stenberg, Richard M., Goins, William F., Stinski, Mark F.

“…The DNA templates containing immediate early (IE) genes of human cytomegalovirus (CMV) were transcribed in vitro by using a HeLa cell extract. When IE region…”
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