Search Results - "Gohr, Claudia M"

Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage by Rosenthal, Ann K., Gohr, Claudia M., Ninomiya, James, Wakim, Bassam T.

“…Objective Articular cartilage vesicles (ACVs) are extracellular organelles found in normal articular cartilage. While they were initially defined by their…”
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The Role of ANK in Calcium Pyrophosphate Deposition Disease by Mitton-Fitzgerald, Elizabeth, Gohr, Claudia M., Bettendorf, Brittany, Rosenthal, Ann K.

“…The protein product of the progressive ankylosis gene, known as ANK, is a 492-amino acid multi-pass transmembrane protein. This protein is critical for the…”
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The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes by Rosenthal, Ann K, Gohr, Claudia M, Mitton-Fitzgerald, Elizabeth, Lutz, Megan K, Dubyak, George R, Ryan, Lawrence M

“…Extracellular ATP (eATP) is released by articular chondrocytes under physiological and pathological conditions. High eATP levels cause pathologic…”
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Osteopontin promotes pathologic mineralization in articular cartilage by Rosenthal, Ann K., Gohr, Claudia M., Uzuki, Miwa, Masuda, Ikuko

“…Calcium pyrophosphate dihydrate (CPPD) crystals are commonly found in osteoarthritic joint tissues, where they predict severe disease. Unlike other types of…”
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The TNFRSF11B mutation associated with calcium pyrophosphate deposition disease results in ineffective osteoclast suppression by Mitton-Fitzgerald, Elizabeth, Gohr, Claudia M, Williams, Charlene J, Ortiz, Amaryllis, Mbalaviele, Gabriel, Rosenthal, Ann K

“…TNFRSF11B encodes for osteoprotegerin (OPG) and was recently identified as the CCAL1 locus associated with familial calcium pyrophosphate deposition disease…”
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Effects of the TNFRSF11B Mutation Associated With Calcium Pyrophosphate Deposition Disease in Osteoclastogenesis in a Murine Model by Mitton‐Fitzgerald, Elizabeth, Gohr, Claudia M., Williams, Charlene J., Ortiz, Amaryllis, Mbalaviele, Gabriel, Rosenthal, Ann K.

“…Objective The gene TNFRSF11B encodes for osteoprotegerin (OPG) and was recently identified as the CCAL1 locus associated with familial calcium pyrophosphate…”
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Calcific Tendonitis : A Model by Gohr, Claudia M., Fahey, Mark, Rosenthal, Ann K.

“…Calcific tendonitis is a common clinical condition associated with high rates of tendon rupture, prolonged symptoms, and poor response to therapy. Little is…”
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Identification of Common Pathogenic Pathways Involved in Hemochromatosis Arthritis and Calcium Pyrophosphate Deposition Disease: a Review by Mitton-Fitzgerald, Elizabeth, Gohr, Claudia M., Williams, Charlene M., Rosenthal, Ann K.

“…Objectives Arthritis is a common clinical manifestation of hereditary hemochromatosis (HH), and HH is one of a handful of conditions linked to calcium…”
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Autophagy Modulates Articular Cartilage Vesicle Formation in Primary Articular Chondrocytes by Rosenthal, Ann K., Gohr, Claudia M., Mitton-Fitzgerald, Elizabeth, Grewal, Rupinder, Ninomiya, James, Coyne, Carolyn B., Jackson, William T.

“…Chondrocyte-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-classical protein secretion, intercellular…”
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The serine protease inhibitor trappin-2 is present in cartilage and synovial fluid in osteoarthritis by JAOVISIDHA, Kanyakorn, ETIM, Ann, YAMAKAWA, Koji, MASUDA, Ikuko, GOHR, Claudia M, WAKIM, Bassam T, BOONAPATCHAROEN, Nimaradee, NINOMIYA, James, ROSENTHAL, Ann K

“…OBJECTIVE: Trappins are small serine protease inhibitors bound to extracellular matrix (ECM) through the actions of transglutaminase (TGase) enzymes. Trappin-2…”
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Articular cartilage vesicles contain RNA by Mitton, Elizabeth, Gohr, Claudia M., McNally, Mark T., Rosenthal, Ann K.

“…Small membrane-bound extracellular organelles known as articular cartilage matrix vesicles (ACVs) participate in pathologic mineralization in osteoarthritic…”
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Advanced Glycation End Products Increase Transglutaminase Activity in Primary Porcine Tenocytes by Rosenthal, Ann K., Gohr, Claudia M., Mitton, Elizabeth, Monnier, Vincent, Burner, Todd

“…ObjectivesTendon abnormalities, such as increased stiffness, thickness, and excess calcification, occur commonly in patients with diabetes mellitus and cause…”
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Transglutaminase contributes to CPPD crystal formation in osteoarthritis by Heinkel, David, Gohr, Claudia M, Uzuki, Miwa, Rosenthal, Ann K

“…Calcium pyrophosphate dihydrate (CPPD) crystals are common components of osteoarthritic joints and correlate with a poor prognosis. Transglutaminase (Tgase)…”
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Regulation of transglutaminase activity in articular chondrocytes through thrombin receptor-mediated factor XIII synthesis by Rosenthal, Ann K, Mosesson, Michael W, Gohr, Claudia M, Masuda, Ikuko, Heinkel, David, Seibenlist, Kevin R

“…Transglutaminases are a family of enzymes that catalyze the formation of epsilon-(gamma-glutamyl)lysine isopeptide bonds in proteins, an activity that has been…”
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Type II collagen levels correlate with mineralization by articular cartilage vesicles by Jubeck, Brian, Muth, Emily, Gohr, Claudia M., Rosenthal, Ann K.

“…Objective Pathologic mineralization is common in osteoarthritic (OA) cartilage and may be mediated by extracellular organelles known as articular cartilage…”
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AGEs stimulate transglutaminase activity in tenocytes by Rosenthal, Ann K., Muth, Emily, Gohr, Claudia M.

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Collagen and its receptors on articular cartilage vesicles by Rosenthal, Ann K., Muth, Emily, Gohr, Claudia M.

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Characterization of articular calcium-containing crystals by synchrotron FTIR by Rosenthal, A.K., M.D, Mattson, E., B.S, Gohr, C.M., B.S, Hirschmugl, C.J., Ph.D

“…Summary Objective Sixty percent of synovial fluids from patients with severe osteoarthritis (OA) contain calcium pyrophosphate dihydrate (CPPD) or basic…”
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Participation of transglutaminase in the activation of latent transforming growth factor β1 in aging articular cartilage by Rosenthal, Ann K., Gohr, Claudia M., Henry, Lisa A., Le, Min

“…Objective Transglutaminase (TGase) catalyzes the calcium‐dependent crosslinking of polypeptide chains, resulting in posttranslational protein modifications…”
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Elimination of Intraluminal Colonization by Antibiotic Lock in Silicone Vascular Catheters by Andris, Deborah A., Krzywda, Elizabeth A., Edmiston, Charles E., Krepel, Candace J., Gohr, Claudia M.

“…An in vitro model was designed to evaluate the efficacy of instilled antimicrobials to reduce or eliminate intraluminal microbial colonization. Minimal…”
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