Search Results - "Gohno, Tatsuyuki"

Contribution of Estrone Sulfate to Cell Proliferation in Aromatase Inhibitor (AI) -Resistant, Hormone Receptor-Positive Breast Cancer by Higuchi, Toru, Endo, Megumi, Hanamura, Toru, Gohno, Tatsuyuki, Niwa, Toshifumi, Yamaguchi, Yuri, Horiguchi, Jun, Hayashi, Shin-Ichi

“…Aromatase inhibitors (AIs) effectively treat hormone receptor-positive postmenopausal breast cancer, but some patients do not respond to treatment or…”
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Increased androgen receptor activity and cell proliferation in aromatase inhibitor-resistant breast carcinoma by Fujii, Rika, Hanamura, Toru, Suzuki, Takashi, Gohno, Tatsuyuki, Shibahara, Yukiko, Niwa, Toshifumi, Yamaguchi, Yuri, Ohnuki, Koji, Kakugawa, Yoichiro, Hirakawa, Hisashi, Ishida, Takanori, Sasano, Hironobu, Ohuchi, Noriaki, Hayashi, Shin-ichi

“…•PSA expression was markedly increased in the AI-resistant recurrence tissues.•Expression of AR and PSA was increased in the AI-resistant cell lines.•Androgens…”
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Estrogen receptor activation by tobacco smoke condensate in hormonal therapy-resistant breast cancer cells by Niwa, Toshifumi, Shinagawa, Yuri, Asari, Yosuke, Suzuki, Kanae, Takanobu, Junko, Gohno, Tatsuyuki, Yamaguchi, Yuri, Hayashi, Shin-ichi

“…•Effect of tobacco smoke condensate on estrogen receptor activity was examined.•TSC significantly activated ERs, and upregulated its endogenous target…”
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Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70‐interacting protein in postmenopausal breast cancer by Kurozumi, Sasagu, Yamaguchi, Yuri, Hayashi, Shin‐ichi, Hiyoshi, Hiromi, Suda, Tetsuji, Gohno, Tatsuyuki, Matsumoto, Hiroshi, Takei, Hiroyuki, Horiguchi, Jun, Takeyoshi, Izumi, Oyama, Tetsunari, Kurosumi, Masafumi

“…The carboxyl terminus of the Hsc70‐interacting protein (CHIP) is considered to induce the ubiquitination and degradation of several oncogenic proteins, and…”
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Individual transcriptional activity of estrogen receptors in primary breast cancer and its clinical significance by Gohno, Tatsuyuki, Seino, Yuko, Hanamura, Toru, Niwa, Toshifumi, Matsumoto, Mitsuyo, Yaegashi, Nobuo, Oba, Hanako, Kurosumi, Masafumi, Takei, Hiroyuki, Yamaguchi, Yuri, Hayashi, Shin‐ichi

“…To predict the efficacy of hormonal therapy at the individual‐level, immunohistochemical methods are used to analyze expression of classical molecular…”
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One DNA Methylation Regulates CHIP Gene Expression of Human Breast Cancer and Predicts Recurrence by Gohno, Tatsuyuki, Hanamura, Toru, Kurosumi, Masafumi, Takei, Hiroyuki, Yamaguchi, Yuri, Hayashi, Shin-Ichi

“…Carboxyl terminus of Hsc70-interacting protein (CHIP) is a ubiquitin ligase that induces ubiquitination and degradation of its target proteins including…”
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Single CpG site methylation controls estrogen receptor gene transcription and correlates with hormone therapy resistance by Tsuboi, Kouki, Nagatomo, Takamasa, Gohno, Tatsuyuki, Higuchi, Toru, Sasaki, Shunta, Fujiki, Natsu, Kurosumi, Masafumi, Takei, Hiroyuki, Yamaguchi, Yuri, Niwa, Toshifumi, Hayashi, Shin-ichi

“…•Alteration of ERα expression occurred in AI resistant and related with acquired resistance.•ERα promoter A dominantly influenced on regulation of ERα…”
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Different epigenetic mechanisms of ERα implicated in the fate of fulvestrant-resistant breast cancer by Tsuboi, Kouki, Kaneko, Yosuke, Nagatomo, Takamasa, Fujii, Rika, Hanamura, Toru, Gohno, Tatsuyuki, Yamaguchi, Yuri, Niwa, Toshifumi, Hayashi, Shin-ichi

“…•We evaluated the mechanism of resistance to fulvestrant in MFR and TFR cell lines.•High methylation levels upstream of the ERα gene were observed in MFR…”
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Possible role of the aromatase-independent steroid metabolism pathways in hormone responsive primary breast cancers by Hanamura, Toru, Niwa, Toshifumi, Gohno, Tatsuyuki, Kurosumi, Masafumi, Takei, Hiroyuki, Yamaguchi, Yuri, Ito, Ken-ichi, Hayashi, Shin-ichi

“…Aromatase inhibitors (AIs) exert antiproliferative effects by reducing local estrogen production from androgens in postmenopausal women with hormone-responsive…”
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Contribution of Estrone Sulfate to Cell Proliferation in Aromatase Inhibitor by Higuchi, Toru, Endo, Megumi, Hanamura, Toru, Gohno, Tatsuyuki, Niwa, Toshifumi, Yamaguchi, Yuri, Horiguchi, Jun, Hayashi, Shin-ichi

“…Aromatase inhibitors (AIs) effectively treat hormone receptor-positive postmenopausal breast cancer, but some patients do not respond to treatment or…”
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Different epigenetic mechanisms of ERa implicated in the fate of fulvestrant-resistant breast cancer by Tsuboi, Kouki, Kaneko, Yosuke, Nagatomo, Takamasa, Fujii, Rika, Hanamura, Toru, Gohno, Tatsuyuki, Yamaguchi, Yuri, Niwa, Toshifumi, Hayashi, Shin-ichi

“…Approximately 70% of breast cancers express estrogen receptor α (ERα), which plays critical roles in breast cancer development. Fulvestrant has been…”
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Androgen metabolite-dependent growth of hormone receptor-positive breast cancer as a possible aromatase inhibitor-resistance mechanism by Hanamura, Toru, Niwa, Toshifumi, Nishikawa, Sayo, Konno, Hiromi, Gohno, Tatsuyuki, Tazawa, Chika, Kobayashi, Yasuhito, Kurosumi, Masafumi, Takei, Hiroyuki, Yamaguchi, Yuri, Ito, Ken-ichi, Hayashi, Shin-ichi

“…Aromatase inhibitors (AIs) have been reported to exert their antiproliferative effects in postmenopausal women with hormone receptor-positive breast cancer not…”
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Estrogen Response element-GFP (ERE-GFP) introduced MCF-7 cells demonstrated the coexistence of multiple estrogen-deprivation resistant mechanisms by Fujiki, Natsu, Konno, Hiromi, Kaneko, Yosuke, Gohno, Tatsuyuki, Hanamura, Toru, Imami, Koshi, Ishihama, Yasushi, Nakanishi, Kyoko, Niwa, Toshifumi, Seino, Yuko, Yamaguchi, Yuri, Hayashi, Shin-ichi

“…•We established plural estrogen deprivation resistant cell lines from MCF-7 cells.•These cells were established by monitoring ER activity with GFP…”
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Variation in Use of Estrogen Receptor-α Gene Promoters in Breast Cancer Compared by Quantification of Promoter-Specific Messenger RNA by Higuchi, Toru, Gohno, Tatsuyuki, Nagatomo, Takamasa, Tokiniwa, Hideaki, Niwa, Toshifumi, Horiguchi, Jun, Oyama, Tetsunari, Takeyoshi, Izumi, Hayashi, Shin-ichi

“…Micro-Abstract Estrogen receptor (ER)-α has multiple promoters upstream of the transcriptional start points in its gene. We examined the promoter usage of 43…”
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Abstract 1313: The androgen metabolite-dependent growth of hormone receptor-positive breast cancer as a possible aromatase inhibitor resistance mechanism by Hanamura, Toru, Niwa, Toshifumi, Nishikawa, Sayo, Konno, Hiromi, Gohno, Tatsuyuki, Chika Tazawa, Chika, Kobayashi, Yasuhito, Kurosumi, Masafumi, Takei, Hiroyuki, Yamaguchi, Yuri, Ken-ichi Ito, Ken-ichi, Hayashi, Shin-ichi

“…Introduction: Aromatase inhibitors (AIs) have been reported to exert their anti-proliferative effects not only by reducing estrogen production but also by…”
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