Curcumin as a natural potential drug candidate against important zoonotic viruses and prions: A narrative review

Zoonotic diseases are major public health concerns and undeniable threats to human health. Among Zoonotic diseases, zoonotic viruses and prions are much more difficult to eradicate, as they result in higher infections and mortality rates. Several investigations have shown curcumin, the active ingred...

Full description

Saved in:

Bibliographic Details
Published in:	Phytotherapy research Vol. 38; no. 6; pp. 3080 - 3121
Main Authors:	Azarkar, Setareh, Abedi, Masoud, Lavasani, Ali Sheikh Olya, Ammameh, Atefeh Heidar, Goharipanah, Fatemeh, Baloochi, Kimiya, Bakhshi, Hasan, Jafari, Amirsajad
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-06-2024
Subjects:	Animals Antiviral Agents - pharmacology COVID-19 - virology COVID-19 Drug Treatment Curcumin Curcumin - pharmacology Dengue fever Dengue Virus - drug effects Drug development Humans Immune system Inflammation Influenza A Influenza A virus - drug effects Microorganisms Oxidants Oxidizing agents Pharmacology Prion protein Prions Prions - drug effects Public health Reviews SARS-CoV-2 - drug effects Severe acute respiratory syndrome coronavirus 2 Vector-borne diseases Viral diseases Viruses Zoonoses Zoonoses - drug therapy Zoonoses - virology natural products prion phytochemicals zoonotic viruses curcumin
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Zoonotic diseases are major public health concerns and undeniable threats to human health. Among Zoonotic diseases, zoonotic viruses and prions are much more difficult to eradicate, as they result in higher infections and mortality rates. Several investigations have shown curcumin, the active ingredient of turmeric, to have wide spectrum properties such as anti-microbial, anti-vascular, anti-inflammatory, anti-tumor, anti-neoplastic, anti-oxidant, and immune system modulator properties. In the present study, we performed a comprehensive review of existing in silico, in vitro, and in vivo evidence on the antiviral (54 important zoonotic viruses) and anti-prion properties of curcumin and curcuminoids in PubMed, Google Scholar, Science Direct, Scopus, and Web of Science databases. Database searches yielded 13,380 results, out of which 216 studies were eligible according to inclusion criteria. Of 216 studies, 135 (62.5%), 24 (11.1%), and 19 (8.8%) were conducted on the effect of curcumin and curcuminoids against SARS-CoV-2, Influenza A virus, and dengue virus, respectively. This review suggests curcumin and curcuminoids as promising therapeutic agents against a wide range of viral zoonoses by targeting different proteins and signaling pathways.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.8119