Study of the Complexation of Oxacillin in 1‑(4-Carbomethoxypyrrolidone)-Terminated PAMAM Dendrimers

Study of the Complexation of Oxacillin in 1‑(4-Carbomethoxypyrrolidone)-Terminated PAMAM Dendrimers

The complexation of oxacillin to three generations of 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers was studied with NMR in CD3OD and CDCl3. The stochiometries, which were determined from Job plots, were found to be both solvent- and generation-dependent. The dissociation constants (K d)...

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Bibliographic Details
Published in:The journal of physical chemistry. B Vol. 117; no. 47; pp. 14865 - 14874
Main Authors: Hansen, Jon S, Ficker, Mario, Petersen, Johannes F, Nielsen, Bjarne E, Gohar, Saira, Christensen, Jørn B
Format: Journal Article
Language:English
Published: Washington, DC American Chemical Society 27-11-2013
Subjects:
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - chemistry
Binding
Biological and medical sciences
Complexation
Constants
Dendrimers
Dendrimers - chemistry
Drug Carriers - chemistry
Energy of dissociation
Fundamental and applied biological sciences. Psychology
Magnetic Resonance Spectroscopy
Molecular biophysics
Nuclear magnetic resonance
Oxacillin - administration & dosage
Oxacillin - chemistry
Physical chemistry
Physical chemistry in biology
Pyrrolidinones - chemistry
Titration
Complexation
Oxacillin
Pyrrolidone derivatives
Nuclear magnetic resonance
Dendritic structure
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Summary:The complexation of oxacillin to three generations of 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers was studied with NMR in CD3OD and CDCl3. The stochiometries, which were determined from Job plots, were found to be both solvent- and generation-dependent. The dissociation constants (K d) and Gibbs energies for complexation of oxacillin into the 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimer hosts were determined by 1H NMR titrations and showed weaker binding of oxacillin upon increasing the size (generation) of the dendrimer.
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ISSN:1520-6106
1520-5207
DOI:10.1021/jp408613z