Search Results - "Goh, Yeow Tee"

Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure by Hughes, Timothy P, Mauro, Michael J, Cortes, Jorge E, Minami, Hironobu, Rea, Delphine, DeAngelo, Daniel J, Breccia, Massimo, Goh, Yeow-Tee, Talpaz, Moshe, Hochhaus, Andreas, le Coutre, Philipp, Ottmann, Oliver, Heinrich, Michael C, Steegmann, Juan L, Deininger, Michael W.N, Janssen, Jeroen J.W.M, Mahon, Francois-Xavier, Minami, Yosuke, Yeung, David, Ross, David M, Tallman, Martin S, Park, Jae H, Druker, Brian J, Hynds, David, Duan, Yuyan, Meille, Christophe, Hourcade-Potelleret, Florence, Vanasse, K. Gary, Lang, Fabian, Kim, Dong-Wook

“…Asciminib, a novel ABL tyrosine kinase inhibitor that targets the myristoyl site of the molecule rather than the ATP-binding domain, showed mainly low-grade…”
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The first-in-human study of the pan-PIM kinase inhibitor PIM447 in patients with relapsed and/or refractory multiple myeloma by Raab, Marc S., Thomas, Sheeba K., Ocio, Enrique M., Guenther, Andreas, Goh, Yeow-Tee, Talpaz, Moshe, Hohmann, Nicolas, Zhao, Sylvia, Xiang, Fang, Simon, Carl, Vanasse, K. Gary, Kumar, Shaji K.

“…PIM447, a novel pan-PIM inhibitor, has shown preclinical activity in multiple myeloma (MM). In the multicenter, open-label, first-in-human study, patients with…”
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Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial by Kantarjian, Hagop M, Prof, Hochhaus, Andreas, Prof, Saglio, Giuseppe, Prof, De Souza, Carmino, Prof, Flinn, Ian W, MD, Stenke, Leif, MD, Goh, Yeow-Tee, MD, Rosti, Gianantonio, Prof, Nakamae, Hirohisa, MD, Gallagher, Neil J, MD, Hoenekopp, Albert, MD, Blakesley, Rick E, PhD, Larson, Richard A, Prof, Hughes, Timothy P, Prof

“…Summary Background Nilotinib has shown greater efficacy than imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid…”
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Respiratory virus infection after allogeneic hematopoietic stem cell transplant in a tropical center: Predictive value of the immunodeficiency scoring index by Wang, Lin, Allen, John, Diong, Colin, Goh, Yeow‐Tee, Gopalakrishnan, Sathish, Ho, Aloysius, Hwang, William, Lim, Francesca, Oon, Lynette, Tan, Thuan‐Tong, Linn, Yeh‐Ching, Tan, Ban Hock

“…Background Respiratory virus infection (RVI) is a prevalent infection in patients after allogeneic hematopoietic stem cell transplant (allo‐HSCT) and can…”
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Long‐term renal outcome after allogeneic hemopoietic stem cell transplant: A comprehensive analysis of risk factors in an Asian patient population by Zhou, Wei, Sultana, Rehena, Diong, Colin, Goh, Yeow‐Tee, Gopalakrishnan, Sathish, Ho, Aloysius, Hwang, William, Koh, Liang‐Piu, Koh, Mickey, Loh, Yvonne, Tan, Patrick, Linn, Yeh‐Ching

“…Allogeneic hemopoietic stem cell transplantation (allo‐HSCT) poses a significant challenge to renal function due to multiple drug‐ and complication‐related…”
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Variation in immunoglobulin use and impact on survival in myeloma by Chai, Khai Li, Wellard, Cameron, Thao, LTP, Aoki, Naomi, Moore, Elizabeth M, Augustson, Bradley M, Bapat, Akshay, Blacklock, Hilary, Chng, Wee J, Cooke, Rachel, Forsyth, Cecily J, Goh, Yeow‐Tee, Hamad, Nada, Harrison, Simon J, Ho, P Joy, Hocking, Jay, Kerridge, Ian, Kim, Jin Seok, Kim, Kihyun, King, Tracy, McCaughan, Georgia J, Mollee, Peter, Morrissey, C Orla, Murphy, Nick, Quach, Hang, Tan, Xuan Ni, Tso, Allison CY, Wong, Kimberly SQ, Yoon, Sung‐Soo, Spencer, Andrew, Wood, Erica M, McQuilten, Zoe K

“…Serious infection is common in patients with multiple myeloma due to immune deficiency from the underlying disease and/or its treatment. Immunoglobulin…”
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Chronic myeloid leukemia in the Asia-Pacific region: Current practice, challenges and opportunities in the targeted therapy era by Kim, Dong-Wook, Banavali, Shripad D, Bunworasate, Udomsak, Goh, Yeow-Tee, Ganly, Peter, Huang, He, Irving, Ian, Jootar, Saengsuree, Goh, Hyun-Gyung, Koh, Liang-Piu, Li, Wei, Naoe, Tomoki, Ng, Soo-Chin, Purushotaman, Visalachy, Reksodiputro, Harryanto, Shih, Lee-Yung, Tang, Jih-Luh, Tojo, Arinobu, Wang, Jianmin, Wong, Raymond

“…Abstract Chronic myeloid leukemia (CML) management varies across Asia due to disparities in affluence and healthcare provision. We surveyed CML management…”
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Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial by van Rhee, Frits, Prof, Wong, Raymond S, Prof, Munshi, Nikhil, Prof, Rossi, Jean-Francois, Prof, Ke, Xiao-Yan, Prof, Fosså, Alexander, MD, Simpson, David, MD, Capra, Marcelo, MD, Liu, Ting, MD, Hsieh, Ruey Kuen, MD, Goh, Yeow Tee, MD, Zhu, Jun, MD, Cho, Seok-Goo, MD, Ren, Hanyun, MD, Cavet, James, MD, Bandekar, Rajesh, PhD, Rothman, Margaret, PhD, Puchalski, Thomas A, PharmD, Reddy, Manjula, MSc, van de Velde, Helgi, MD, Vermeulen, Jessica, MD, Casper, Corey, Prof

“…Summary Background Multicentric Castleman's disease is a rare lymphoproliferative disorder driven by dysregulated production of interleukin 6. No randomised…”
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Frontline bortezomib, rituximab, cyclophosphamide, doxorubicin, and prednisone (VR-CAP) versus rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in transplantation-ineligible patients with newly diagnosed mantle cell lymphoma: final overall survival results of a randomised, open-label, phase 3 study by Robak, Tadeusz, Jin, Jie, Pylypenko, Halyna, Verhoef, Gregor, Drach, Johannes, Pereira, Juliana, Tumyan, Gayane, Okamoto, Rumiko, Appiani, Carlos, Cavalli, Franco, Sheliga, Adriana, Teixeira, Adriana, Tomita, Akihiro, Rocafiguera, Albert Oriol, Suvorov, Alexander, Kuzmin, Alexy, Mezlini, Amel, Bosly, Andre, Van De Velde, Ann, Illes, Árpád, Garichochea, Bernardo, Gabarrón, Caballero, Cao, Carmen, Souza, Carmino, Farber, Charles, Burcoveanu, Cristina Ileana, Cebotaru, Cristina Ligia, Truica, Cristina-Ligia, Maruyama, Dai, Belada, David, Udovitsa, Dmitry, Dolores, Morra, Enrica, Späth-Schwalbe, Ernst, Gonzalez-Barca, Eva, Osmanov, Evgenii, Heß, Georg, Manikhas, Georgii, Babu, Govind, Rekhtman, Grigoriy, Rossi, Guiseppe, Marques, Herlander, Bumbea, Horia, Huang, Huiqiang, Choi, Ilseung, Bulavina, Irina, Lysenko, Irina, Avivi, Irit, Kryachok, Iryna, Zaucha, Jan Maciej, Novak, Jan, Díaz, Joaquín, Demeter, Judit, Zhu, Jun, Vilchevskaya, Kateryna, Tobinai, Kensei, Ando, Kiyoshi, Abdulkadryrov, Kudrat, Shih, Lee-Yung, Gumus, Mahmut, De Wit, Maike, Capra, Marcelo, Golubeva, Marina, Crump, Michael, Baccarani, Michele, Egyed, Miklós, Udvardy, Miklos, Kurosawa, Mitsutoshi, Uike, Naokuni, Khuageva, Nuriet, Gladkov, Oleg, Samoilova, Olga, Serduk, Olga, Santi, Patricia, Stoia, Razvan, Gressin, Remy, Arranz, Reyes, Greil, Richard, Cancelado, Sergio, Nair, Sreejith, Le Gouill, Steven, Van Steenweghen, Steven, Scheider, Tatiana, Shimoyama, Tatsu, Kinoshita, Tomohiro, Pavlov, Viacheslav, Phooshkooru, Vijay Rao, Lima, Vladimir, Merkulov, Vladimir, Nawarawong, Weerasak, Hong, Xiaonan, Ke, Xiaoyan, Terui, Yasuhito, Tee Goh, Yeow, Dunaev, Yuri, Lorie, Yurii, Wang, Zhao, Shen, Zhixiang, Borbenyi, Zita, Masliak, Zvenyslava

“…In the LYM-3002 study, the efficacy and safety of frontline bortezomib plus rituximab, cyclophosphamide, doxorubicin, and prednisone (VR-CAP) and rituximab,…”
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Asciminib in Newly Diagnosed Chronic Myeloid Leukemia by Hochhaus, Andreas, Wang, Jianxiang, Kim, Dong-Wook, Kim, Dennis Dong Hwan, Mayer, Jiri, Goh, Yeow-Tee, le Coutre, Philipp, Takahashi, Naoto, Kim, Inho, Etienne, Gabriel, Andorsky, David, Issa, Ghayas C., Larson, Richard A., Bombaci, Felice, Kapoor, Shruti, McCulloch, Tracey, Malek, Kamel, Yau, Lillian, Ifrah, Sophie, Hoch, Matthias, Cortes, Jorge E., Hughes, Timothy P.

“…Asciminib, an agent that targets the myristoyl pocket of BCR::ABL, was compared with imatinib and with imatinib plus second-generation tyrosine kinase…”
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A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer by Ng, King Pan, Hillmer, Axel M, Chuah, Charles T H, Juan, Wen Chun, Ko, Tun Kiat, Teo, Audrey S M, Ariyaratne, Pramila N, Takahashi, Naoto, Sawada, Kenichi, Fei, Yao, Soh, Sheila, Lee, Wah Heng, Huang, John W J, Allen, John C, Woo, Xing Yi, Nagarajan, Niranjan, Kumar, Vikrant, Thalamuthu, Anbupalam, Poh, Wan Ting, Ang, Ai Leen, Mya, Hae Tha, How, Gee Fung, Yang, Li Yi, Koh, Liang Piu, Chowbay, Balram, Chang, Chia-Tien, Nadarajan, Veera S, Chng, Wee Joo, Than, Hein, Lim, Lay Cheng, Goh, Yeow Tee, Zhang, Shenli, Poh, Dianne, Tan, Patrick, Seet, Ju-Ee, Ang, Mei-Kim, Chau, Noan-Minh, Ng, Quan-Sing, Tan, Daniel S W, Soda, Manabu, Isobe, Kazutoshi, Nöthen, Markus M, Wong, Tien Y, Shahab, Atif, Ruan, Xiaoan, Cacheux-Rataboul, Valère, Sung, Wing-Kin, Tan, Eng Huat, Yatabe, Yasushi, Mano, Hiroyuki, Soo, Ross A, Chin, Tan Min, Lim, Wan-Teck, Ruan, Yijun, Ong, S Tiong

“…Intrinsic resistance to tyrosine kinase inhibitor (TKI) drugs is limiting the progress of targeted cancer therapies. The efficacy of TKIs relies on their…”
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Posaconazole vs. Fluconazole or Itraconazole Prophylaxis in Patients with Neutropenia by Cornely, Oliver A, Maertens, Johan, Winston, Drew J, Perfect, John, Ullmann, Andrew J, Walsh, Thomas J, Helfgott, David, Holowiecki, Jerzy, Stockelberg, Dick, Goh, Yeow-Tee, Petrini, Mario, Hardalo, Cathy, Suresh, Ramachandran, Angulo-Gonzalez, David

“…In this randomized trial of patients undergoing treatment for acute myelogenous leukemia or the myelodysplastic syndrome, prophylaxis with posaconazole…”
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Clinical profile of dasatinib in Asian and non-Asian patients with chronic myeloid leukemia by Kim, Dong-Wook, Goh, Yeow-Tee, Hsiao, Hui-Hua, Caguioa, Priscilla B., Kim, Dongho, Kim, Wan-Seok, Saikia, Tapan, Agrawal, Shruti, Roy, Amit, Dai, David, Bradley-Garelik, M. Brigid, Mukhopadhyay, Jaydip, Jootar, Saengsuree

“…Resistance and intolerance to imatinib are of particular clinical relevance to Asian patients because of their lower body surface area. Dasatinib is 325-fold…”
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Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti–IL-6) in multiple myeloma by San-Miguel, Jesús, Bladé, Joan, Shpilberg, Ofer, Grosicki, Sebastian, Maloisel, Frédéric, Min, Chang-Ki, Polo Zarzuela, Marta, Robak, Tadeusz, Prasad, Sripada V.S.S., Tee Goh, Yeow, Laubach, Jacob, Spencer, Andrew, Mateos, María-Victoria, Palumbo, Antonio, Puchalski, Tom, Reddy, Manjula, Uhlar, Clarissa, Qin, Xiang, van de Velde, Helgi, Xie, Hong, Orlowski, Robert Z.

“…Because interleukin-6 (IL-6) is considered important in the proliferation of early multiple myeloma (MM), we hypothesized that the addition of the anti-IL-6…”
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Dasatinib in Imatinib- Resistant or Imatinib-Intolerant Chronic Myeloid Leukemia in Blast Phase After 2 Years of Follow-Up in a Phase 3 Study: Efficacy and Tolerability of 140 Milligrams Once Daily and 70 Milligrams Twice Daily by SAGLIO, Giuseppe, HOCHHAUS, Andreas, CHAO ZHU, DOMBRET, Herve, YEOW TEE GOH, MASSZI, Tamas, PASQUINI, Ricardo, MALOISEL, Frederic, ERBEN, Philipp, CORTES, Jorge, PAQUETTE, Ronald, BRADLEY-GARELIK, M. Brigid

“…In a phase 3 study, the authors assessed the effects of dasatinib at doses of 140 mg once daily and 70 mg twice daily in patients who had either chronic…”
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Consensus recommendations for optimising the diagnosis and treatment of paroxysmal nocturnal haemoglobinuria in Singapore by Goh, Yeow Tee, Yap, Eng Soo, Tan, Chuen Wen, Tan, Daryl, Loh, Yvonne Su Ming, Lee, Yuh Shan, Chong, Lip Leong, Lim, Zi Yi, Than, Hein

“…Paroxysmal nocturnal haemoglobinuria (PNH) is a rare haematologic disease characterised by intravascular haemolysis, thrombophilia and bone marrow failure…”
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Hepatitis B virus reactivation in B-cell lymphoma patients treated with rituximab: Analysis from the Asia Lymphoma Study Group by Kim, Seok Jin, Hsu, Chiun, Song, Yu-Qin, Tay, Kevin, Hong, Xiao-Nan, Cao, Junning, Kim, Jin Seok, Eom, Hyeon Seok, Lee, Joon Hyeok, Zhu, Jun, Chang, Kian-Meng, Reksodiputro, Arry Harryanto, Tan, Daryl, Goh, Yeow Tee, Lee, Jejung, Intragumtornchai, Tanin, Chng, Wee-Joo, Cheng, Ann-Lii, Lim, Soon Thye, Suh, Cheolwon, Kwong, Yok-Lam, Kim, Won Seog

“…Abstract Background Hepatitis B virus (HBV) reactivation is increasing, as rituximab has become widely used for B-cell lymphoma. Thus, prevention and…”
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The establishment of a multiple myeloma clinical registry in the Asia-Pacific region: The Asia-Pacific Myeloma and Related Diseases Registry (APAC MRDR) by Aoki, Naomi, Chen, Pin-Yen, Chen, Wenming, Chng, Wee Joo, Gan, Gin Gin, Goh, Yeow Tee, Hou, Jian, Huang, Jeffrey, Kim, Kihyun, Lee, Je Jung, Lu, Jin, McQuilten, Zoe K, Min, Chang Ki, Moore, Elizabeth, Oliver, Laura, Waters, Neil A, Wellard, Cameron, Wood, Erica M, Yeh, Su-Peng, Spencer, Andrew

“…Multiple myeloma (MM) is the second most common haematological cancer worldwide. Along with related diseases including monoclonal gammopathy of undetermined…”
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DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes by Kizhakeyil, Atish, Zaini, Nurmahirah Binte Mohammed, Poh, Zhi Sheng, Wong, Brandon Han Siang, Loh, Xinpeng, Ng, Aik Seng, Low, Zun Siong, Prasannan, Praseetha, Gong, Chun, Tan, Michelle Guet Khim, Nagarajan, Chandramouli, Huang, Dachuan, Lu, Pang Wan, Lim, Jing Quan, Barrans, Sharon, Ong, Choon Kiat, Lim, Soon Thye, Chng, Wee Joo, Follows, George, Hodson, Daniel J, Du, Ming Qing, Goh, Yeow Tee, Tan, Suat Hoon, Grigoropoulos, Nicholas Francis, Verma, Navin Kumar

“…Keywords: DDX3X mutation, Hematolymphoid malignancy, Prognosis, Tumour metastasis, Drug resistance…”
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CML-466 Asciminib Provides Durable Molecular Responses in Patients With Chronic Myeloid Leukemia in Chronic Phase (CML-CP) With the T315I Mutation: Updated Efficacy and Safety Data From a Phase I Trial by Hughes, Timothy P., Cortes, Jorge E., Réa, Delphine, Mauro, Michael J., Hochhaus, Andreas, Kim, Dong-Wook, Sasaki, Koji, Lang, Fabian, Heinrich, Michael C., Breccia, Massimo, Deininger, Michael, Goh, Yeow-Tee, Janssen, Jeroen J. W.M, Talpaz, Moshe, Coutre, Philipp le, Kapoor, Shruti, Cacciatore, Silvia, Polydoros, Fotis, Agrawal, Nithya, Mahon, Francois-Xavier

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