Search Results - "Goh, Pollyanna"

A systematic evaluation of integration free reprogramming methods for deriving clinically relevant patient specific induced pluripotent stem (iPS) cells by Goh, Pollyanna A, Caxaria, Sara, Casper, Catharina, Rosales, Cecilia, Warner, Thomas T, Coffey, Pete J, Nathwani, Amit C

“…A systematic evaluation of three different methods for generating induced pluripotent stem (iPS) cells was performed using the same set of parental cells in…”
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Cerebral organoids with chromosome 21 trisomy secrete Alzheimer’s disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy by Fertan, Emre, Böken, Dorothea, Murray, Aoife, Danial, John S. H., Lam, Jeff Y. L., Wu, Yunzhao, Goh, Pollyanna A., Alić, Ivan, Cheetham, Matthew R., Lobanova, Evgeniia, Zhang, Yu P., Nižetić, Dean, Klenerman, David

“…Understanding the role of small, soluble aggregates of beta-amyloid (Aβ) and tau in Alzheimer’s disease (AD) is of great importance for the rational design of…”
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Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox by Yang, Jun, Milasta, Sandra, Hu, Dongli, AlTahan, Alaa M, Interiano, Rodrigo B, Zhou, Junfang, Davidson, Jesse, Low, Jonathan, Lin, Wenwei, Bao, Ju, Goh, Pollyanna, Nathwani, Amit C, Wang, Ruoning, Wang, Yingdi, Ong, Su Sien, Boyd, Vincent A, Young, Brandon, Das, Sourav, Shelat, Anang, Wu, Yinan, Li, Zhenmei, Zheng, Jie J, Mishra, Ashutosh, Cheng, Yong, Qu, Chunxu, Peng, Junmin, Green, Douglas R, White, Stephen, Guy, R Kiplin, Chen, Taosheng, Davidoff, Andrew M

“…Histone lysine demethylases facilitate the activity of oncogenic transcription factors, including possibly MYC. Here we show that multiple histone demethylases…”
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Generation of Integration-Free Patient Specific iPS Cells Using Episomal Plasmids Under Feeder Free Conditions by Caxaria, Sara, Arthold, Susanne, Nathwani, Amit C, Goh, Pollyanna Agnes

“…Reprogramming somatic cells into a pluripotent state involves the overexpression of transcription factors leading to a series of changes that end in the…”
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Modeling Down syndrome in cells: From stem cells to organoids by Gough, Gillian, O'Brien, Niamh L, Alic, Ivan, Goh, Pollyanna A, Yeap, Yee Jie, Groet, Jurgen, Nizetic, Dean, Murray, Aoife

“…Down Syndrome (DS) is a complex chromosomal disorder, with neurological issues, featuring among the symptoms. Primary neuronal cells and tissues are extremely…”
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Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain by Alić, Ivan, Goh, Pollyanna A., Murray, Aoife, Portelius, Erik, Gkanatsiou, Eleni, Gough, Gillian, Mok, Kin Y., Koschut, David, Brunmeir, Reinhard, Yeap, Yee Jie, O’Brien, Niamh L., Groet, Jürgen, Shao, Xiaowei, Havlicek, Steven, Dunn, N. Ray, Kvartsberg, Hlin, Brinkmalm, Gunnar, Hithersay, Rosalyn, Startin, Carla, Hamburg, Sarah, Phillips, Margaret, Pervushin, Konstantin, Turmaine, Mark, Wallon, David, Rovelet-Lecrux, Anne, Soininen, Hilkka, Volpi, Emanuela, Martin, Joanne E., Foo, Jia Nee, Becker, David L., Rostagno, Agueda, Ghiso, Jorge, Krsnik, Željka, Šimić, Goran, Kostović, Ivica, Mitrečić, Dinko, Francis, Paul T., Blennow, Kaj, Strydom, Andre, Hardy, John, Zetterberg, Henrik, Nižetić, Dean

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Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain by Alić, Ivan, Goh, Pollyanna A., Murray, Aoife, Portelius, Erik, Gkanatsiou, Eleni, Gough, Gillian, Mok, Kin Y., Koschut, David, Brunmeir, Reinhard, Yeap, Yee Jie, O’Brien, Niamh L., Groet, Jürgen, Shao, Xiaowei, Havlicek, Steven, Dunn, N. Ray, Kvartsberg, Hlin, Brinkmalm, Gunnar, Hithersay, Rosalyn, Startin, Carla, Hamburg, Sarah, Phillips, Margaret, Pervushin, Konstantin, Turmaine, Mark, Wallon, David, Rovelet-Lecrux, Anne, Soininen, Hilkka, Volpi, Emanuela, Martin, Joanne E., Foo, Jia Nee, Becker, David L., Rostagno, Agueda, Ghiso, Jorge, Krsnik, Željka, Šimić, Goran, Kostović, Ivica, Mitrečić, Dinko, Francis, Paul T., Blennow, Kaj, Strydom, Andre, Hardy, John, Zetterberg, Henrik, Nižetić, Dean

“…A population of more than six million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)),…”
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Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome by Botté, Alexandra, Lainé, Jeanne, Xicota, Laura, Heiligenstein, Xavier, Fontaine, Gaëlle, Kasri, Amal, Rivals, Isabelle, Goh, Pollyanna, Faklaris, Orestis, Cossec, Jack-Christophe, Morel, Etienne, Rebillat, Anne-Sophie, Nizetic, Dean, Raposo, Graça, Potier, Marie-Claude

“…Enlarged early endosomes have been visualized in Alzheimer's disease (AD) and Down syndrome (DS) using conventional confocal microscopy at a resolution…”
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Comparative study on the therapeutic potential of neurally differentiated stem cells in a mouse model of multiple sclerosis by Payne, Natalie L, Sun, Guizhi, Herszfeld, Daniella, Tat-Goh, Pollyanna A, Verma, Paul J, Parkington, Helena C, Coleman, Harold A, Tonta, Mary A, Siatskas, Christopher, Bernard, Claude C A

“…Transplantation of neural stem cells (NSCs) is a promising novel approach to the treatment of neuroinflammatory diseases such as multiple sclerosis (MS). NSCs…”
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Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co‐express gamma and beta globins by Yang, Cheng‐Tao, French, Anna, Goh, Pollyanna Agnes, Pagnamenta, Alistair, Mettananda, Sachith, Taylor, Jenny, Knight, Sam, Nathwani, Amit, Roberts, David J., Watt, Suzanne M., Carpenter, Lee

“…Summary Human induced pluripotent stem cells (hiPSCs), like embryonic stem cells, are under intense investigation for novel approaches to model disease and for…”
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Differential Coassembly of α1-GABA A Rs Associated with Epileptic Encephalopathy by Hannan, Saad, Affandi, Aida H B, Minere, Marielle, Jones, Charlotte, Goh, Pollyanna, Warnes, Gary, Popp, Bernt, Trollmann, Regina, Nizetic, Dean, Smart, Trevor G

“…GABA receptors (GABA Rs) are profoundly important for controlling neuronal excitability. Spontaneous and familial mutations to these receptors feature…”
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Differential Coassembly of α1-GABAARs Associated with Epileptic Encephalopathy by Hannan, Saad, Affandi, Aida HB, Minere, Marielle, Jones, Charlotte, Goh, Pollyanna, Warnes, Gary, Popp, Bernt, Trollmann, Regina, Nizetic, Dean, Smart, Trevor G

“…GABAA receptors (GABAARs) are profoundly important for controlling neuronal excitability. Spontaneous and familial mutations to these receptors feature…”
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Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration by Murray, Aoife, Letourneau, Audrey, Canzonetta, Claudia, Stathaki, Elisavet, Gimelli, Stefania, Sloan‐Bena, Frederique, Abrehart, Robert, Goh, Pollyanna, Lim, Shuhui, Baldo, Chiara, Dagna‐Bricarelli, Franca, Hannan, Saad, Mortensen, Martin, Ballard, David, Syndercombe Court, Denise, Fusaki, Noemi, Hasegawa, Mamoru, Smart, Trevor G., Bishop, Cleo, Antonarakis, Stylianos E., Groet, Jürgen, Nizetic, Dean

“…Trisomy 21 (T21), Down Syndrome (DS) is the most common genetic cause of dementia and intellectual disability. Modeling DS is beginning to yield pharmaceutical…”
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Alzheimer‐like pathology in trisomy 21 cerebral organoids amenable to pharmacological inhibition reveals BACE2 as a gene‐dose‐sensitive AD‐suppressor in human brain: Development of new models and analysis methods: Multisystem platform models of ADRD by Alic, Ivan, Goh, Pollyanna, Murray, Aoife, Portelius, Erik, Gough, Gillian, Gkanatsiou, Eleni, Wallon, David, Rovelet‐Lecrux, Anne, Rostagno, Agueda, Ghiso, Jorge, Francis, Paul T., Strydom, Andre, Hardy, John, Zetterberg, Henrik, Nizetic, Dean

“…Abstract Background A population of >6 million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21…”
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Alzheimer‐like pathology in trisomy 21 cerebral organoids amenable to pharmacological inhibition reveals BACE2 as a gene‐dose‐sensitive AD‐suppressor in human brain by Alic, Ivan, Goh, Pollyanna, Murray, Aoife, Portelius, Erik, Gough, Gillian, Gkanatsiou, Eleni, Wallon, David, Rovelet‐Lecrux, Anne, Rostagno, Agueda, Ghiso, Jorge, Francis, Paul T., Strydom, Andre, Hardy, John, Zetterberg, Henrik, Nizetic, Dean

“…Background A population of >6 million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)),…”
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Mbd3 Promotes Reprogramming of Primary Human Fibroblasts by Jaffer, Sajjida, Goh, Pollyanna, Abbasian, Mahnaz, Nathwani, Amit C

“…Mbd3 (Methyl-CpG binding domain protein), a core member of NuRD (nucleosome remodelling and deacetylation) is essential for embryogenesis. However, its role in…”
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Mislocalisation of BEST1 in iPSC-derived retinal pigment epithelial cells from a family with autosomal dominant vitreoretinochoroidopathy (ADVIRC) by Carter, David A., Smart, Matthew J. K., Letton, William V. G., Ramsden, Conor M., Nommiste, Britta, Chen, Li Li, Fynes, Kate, Muthiah, Manickam N., Goh, Pollyanna, Lane, Amelia, Powner, Michael B., Webster, Andrew R., da Cruz, Lyndon, Moore, Anthony T., Coffey, Peter J., Carr, Amanda-Jayne F.

“…Autosomal dominant vitreoretinochoroidopathy (ADVIRC) is a rare, early-onset retinal dystrophy characterised by distinct bands of circumferential pigmentary…”
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GENETIC DISSECTION OF SEVERITY AND ONSET MODULATORS FOR ALZHEIMER’S PATHOLOGY IN DOWN SYNDROME USING CELLULAR SYSTEMS by Murray, Aoife, Goh, Pollyanna, Yeap, Yee-Jie, Startin, Carla, Hamburg, Sarah, Hithersay, Rosalyn, d'Souza, Hana, Mok, Kin, Rovelet-Lecrux, Anne, Wallon, David, Choolani, Mahesh, Chan, Jerry, Botte, Alexandra, Potier, Marie-Claude, Augustine, George, Wiseman, Frances K., Fisher, Elizabeth, Tybulewicz, Victor L., Karmiloff-Smith, Annette, Strydom, Andre, Hardy, John, Groet, Jurgen, Nizetic, Dean

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Correction: Comparative Study on the Therapeutic Potential of Neurally Differentiated Stem Cells in a Mouse Model of Multiple Sclerosis by Payne, Natalie L., Sun, Guizhi, Herszfeld, Daniella, Tat-Goh, Pollyanna A., Verma, Paul J., Parkington, Helena C., Coleman, Harold A., Tonta, Mary A., Siatskas, Christopher, Bernard, Claude C. A.

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[P3–168]: GENETIC DISSECTION OF SEVERITY AND ONSET MODULATORS FOR ALZHEIMER's PATHOLOGY IN DOWN SYNDROME USING CELLULAR SYSTEMS by Murray, Aoife, Goh, Pollyanna, Yeap, Yee‐Jie, Startin, Carla, Hamburg, Sarah, Hithersay, Rosalyn, d'Souza, Hana, Mok, Kin, Rovelet‐Lecrux, Anne, Wallon, David, Choolani, Mahesh, Chan, Jerry, Botte, Alexandra, Potier, Marie‐Claude, Augustine, George, Wiseman, Frances K., Fisher, Elizabeth, Tybulewicz, Victor L., Karmiloff‐Smith, Annette, Strydom, Andre, Hardy, John, Groet, Jurgen, Nizetic, Dean

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