Search Results - "Goh, Eyleen L. K."

GABA regulates synaptic integration of newly generated neurons in the adult brain by Song, Hongjun, Ge, Shaoyu, Goh, Eyleen L. K, Sailor, Kurt A, Kitabatake, Yasuji, Ming, Guo-li

“…Adult neurogenesis, the birth and integration of new neurons from adult neural stem cells, is a striking form of structural plasticity and highlights the…”
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Taurine induces proliferation of neural stem cells and synapse development in the developing mouse brain by Shivaraj, Mattu Chetana, Marcy, Guillaume, Low, Guoliang, Ryu, Jae Ryun, Zhao, Xianfeng, Rosales, Francisco J, Goh, Eyleen L K

“…Taurine is a sulfur-containing amino acid present in high concentrations in mammalian tissues. It has been implicated in several processes involving brain…”
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Emerging Intrinsic Therapeutic Targets for Metastatic Breast Cancer by Li, Jiawei, Goh, Eyleen L K, He, Ji, Li, Yan, Fan, Zhimin, Yu, Zhigang, Yuan, Peng, Liu, Dong-Xu

“…Breast cancer is now the most common cancer worldwide, and it is also the main cause of cancer-related death in women. Survival rates for female breast cancer…”
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Class 3 semaphorin mediates dendrite growth in adult newborn neurons through Cdk5/FAK pathway by Ng, Teclise, Ryu, Jae Ryun, Sohn, Jae Ho, Tan, Terence, Song, Hongjun, Ming, Guo-Li, Goh, Eyleen L K

“…Class 3 semaphorins are well-known axonal guidance cues during the embryonic development of mammalian nervous system. However, their activity on postnatally…”
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Choline Ameliorates Disease Phenotypes in Human iPSC Models of Rett Syndrome by Chin, Eunice W. M., Marcy, Guillaume, Yoon, Su-In, Ma, Dongliang, Rosales, Francisco J., Augustine, George J., Goh, Eyleen L. K.

“…Rett syndrome (RTT) is a postnatal neurodevelopmental disorder that primarily affects girls. Mutations in the methyl-CpG-binding protein 2 ( MECP2 ) gene…”
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Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid by Nguyen, Long N., Ma, Dongliang, Shui, Guanghou, Wong, Peiyan, Cazenave-Gassiot, Amaury, Zhang, Xiaodong, Wenk, Markus R., Goh, Eyleen L. K., Silver, David L.

“…Mfsd2a is the major transporter of the omega-3 fatty acid docosahexaenoic acid (DHA) into brain, with Mfsd2a -knockout mice showing reduced DHA in brain,…”
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The Combined Effects of Topography and Stiffness on Neuronal Differentiation and Maturation Using a Hydrogel Platform by Mattiassi, Sabrina, Conner, Abigail A, Feng, Fan, Goh, Eyleen L K, Yim, Evelyn K F

“…Biophysical parameters such as substrate topography and stiffness have been shown independently to elicit profound effects on neuronal differentiation and…”
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A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood-brain barrier by Adriani, Giulia, Ma, Dongliang, Pavesi, Andrea, Kamm, Roger D, Goh, Eyleen L K

“…The neurovascular unit is a complex, interdependent system composed of neurons and neural supporting cells, such as astrocytes, as well as cells that comprise…”
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Distinct Responses of Stem Cells to Telomere Uncapping—A Potential Strategy to Improve the Safety of Cell Therapy by Liu, Chang Ching, Ma, Dong Liang, Yan, Ting‐Dong, Fan, XiuBo, Poon, Zhiyong, Poon, Lai‐Fong, Goh, Su‐Ann, Rozen, Steve G., Hwang, William Ying Khee, Tergaonkar, Vinay, Tan, Patrick, Ghosh, Sujoy, Virshup, David M., Goh, Eyleen L. K., Li, Shang

“…In most human somatic cells, the lack of telomerase activity results in progressive telomere shortening during each cell division. Eventually, DNA damage…”
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A novel microRNA, novel-m009C, regulates methamphetamine rewarding effects by Zhu, Li, Wu, Feifei, Yan, Zhilan, He, Lijun, Wang, Shufei, Hu, Haohao, Goh, Eyleen L. K., Zhu, Yingjie, Guan, Fanglin, Chen, Teng

“…Methamphetamine (METH) is a widely abused psychostimulant, whose hyper-rewarding property is believed to underlie its addictive effect, but the molecular…”
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Regionally-specified second trimester fetal neural stem cells reveals differential neurogenic programming by Fan, Yiping, Marcy, Guillaume, Lee, Eddy S M, Rozen, Steve, Mattar, Citra N Z, Waddington, Simon N, Goh, Eyleen L K, Choolani, Mahesh, Chan, Jerry K Y

“…Neural stem/progenitor cells (NSC) have the potential for treatment of a wide range of neurological diseases such as Parkinson Disease and multiple sclerosis…”
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Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital by Ma, Dongliang, Yoon, Su-In, Yang, Chih-Hao, Marcy, Guillaume, Zhao, Na, Leong, Wan-Ying, Ganapathy, Vinu, Han, Ju, Van Dongen, Antonius M. J., Hsu, Kuei-Sen, Ming, Guo-Li, Augustine, George J., Goh, Eyleen L. K.

“…Rett syndrome is a neurodevelopmental disorder that usually arises from mutations or deletions in methyl-CpG binding protein 2 (MeCP2), a transcriptional…”
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beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones by Goh, Eyleen L K, Young, Ju Kim, Kuwako, Kenichiro, Tessier-Lavigne, Marc, He, Zhigang, Griffin, John W, Ming, Guo-Li

“…Several myelin-associated factors that inhibit axon growth of mature neurons, including Nogo66, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin…”
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mRNA changes in nucleus accumbens related to methamphetamine addiction in mice by Zhu, Li, Li, Jiaqi, Dong, Nan, Guan, Fanglin, Liu, Yufeng, Ma, Dongliang, Goh, Eyleen L. K., Chen, Teng

“…Methamphetamine (METH) is a highly addictive psychostimulant that elicits aberrant changes in the expression of microRNAs (miRNAs) and long non-coding RNAs…”
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MeCP2 Dysfunction in Rett Syndrome and Neuropsychiatric Disorders by Chin, Eunice W M, Goh, Eyleen L K

“…Elucidating the functions of a particular gene is paramount to the understanding of how its dysfunction contributes to disease. This is especially important…”
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Regulation of miR‐128 in the nucleus accumbens affects methamphetamine‐induced behavioral sensitization by modulating proteins involved in neuroplasticity by Li, Jiaqi, Zhu, Li, Su, Hang, Liu, Dan, Yan, Zhilan, Ni, Tong, Wei, Han, Goh, Eyleen L.K., Chen, Teng

“…Methamphetamine (METH) ‐induced behavioral sensitization depends on long‐term neuroplasticity in the mesolimbic dopamine system, especially in the nucleus…”
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Potential Ago2/miR-3068-5p Cascades in the Nucleus Accumbens Contribute to Methamphetamine-Induced Locomotor Sensitization of Mice by Liu, Dan, Liang, Min, Zhu, Li, Zhou, Ting-ting, Wang, Yu, Wang, Rui, Wu, Fei-fei, Goh, Eyleen L. K., Chen, Teng

“…Dysregulation of microRNA (miRNA) biogenesis is involved in drug addiction. Argonaute2 (Ago2), a specific splicing protein involved in the generation of miRNA,…”
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Enhanced differentiation of neural progenitor cells into neurons of the mesencephalic dopaminergic subtype on topographical patterns by Tan, Kenneth K.B, Tann, Jason Y, Sathe, Sharvari R, Goh, Seok Hong, Ma, Dongliang, Goh, Eyleen L.K, Yim, Evelyn K.F

“…Abstract Parkinson's disease (PD) is a neurodegenerative disease attributed to the loss of midbrain dopaminergic (DA) neurons. The current lack of predictive…”
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WNK3 Maintains the GABAergic Inhibitory Tone, Synaptic Excitation and Neuronal Excitability via Regulation of KCC2 Cotransporter in Mature Neurons by Lim, Wee Meng, Chin, Eunice W. M., Tang, Bor Luen, Chen, Tingting, Goh, Eyleen L. K.

“…The activation of chloride (Cl − )permeable gamma (γ)-aminobutyric acid type A(GABA A ) receptors induces synaptic inhibition in mature and excitation in…”
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Rab23 and developmental disorders by Hor, Catherine H H, Tang, Bor Luen, Goh, Eyleen L K

“…Rab23 is a conserved member of the Rab family of small GTPases that regulates membrane trafficking in eukaryotes. It is unique amongst the Rabs in terms of its…”
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