Sodium monofluoroacetate (Compound 1080) poisoning in dogs

Sodium monofluoroacetate (Compound 1080) poisoning in dogs

Sodium monofluoroacetate (Compound 1080) is a widely used pesticide for control of feral animals such as the fox. Accidental poisoning of domestic animals occurs despite strict regulations on 1080 usage. Dogs are particularly susceptible to the toxin. The mechanism of 1080 toxicity, susceptibility o...

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Bibliographic Details
Published in:Australian veterinary journal Vol. 83; no. 8; pp. 474 - 479
Main Authors: Goh, C.S.S, Hodgson, D.R, Fearnside, S.M, Heller, J, Malikides, N
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01-08-2005
Subjects:
Animals
Animals, Domestic
antidotes
Australia
Compound 1080
disease diagnosis
disease prevention
dog diseases
Dog Diseases - chemically induced
Dog Diseases - pathology
Dog Diseases - prevention & control
Dog Diseases - therapy
Dogs
environmental exposure
Fluoroacetates - poisoning
literature reviews
mechanism of action
medical treatment
poisoning
Prognosis
risk assessment
Risk Factors
Rodenticides - poisoning
sodium fluoroacetate
sodium monofluoroacetate
symptoms
toxicity
Australia
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Summary:Sodium monofluoroacetate (Compound 1080) is a widely used pesticide for control of feral animals such as the fox. Accidental poisoning of domestic animals occurs despite strict regulations on 1080 usage. Dogs are particularly susceptible to the toxin. The mechanism of 1080 toxicity, susceptibility of target and non‐target species, persistence of 1080 in the environment and risk of accidental poisoning are discussed. Particular emphasis is placed on 1080 toxicity in the dog. Early recognition of intoxication is most important for prognosis and relies upon characteristic clinical signs and diagnostic findings. The treatment of 1080 intoxication remains a challenge with no proven antidotes. However, there are possible benefits from monoacetin, acetamide, calcium salts, colestipol, activated charcoal, peritoneal dialysis, sodium bicarbonate, neurotransmitter modulators and four‐methylpyrazole. A recommended treatment protocol for 1080 toxicosis in dogs is included. Safety measures such as the use of wire dog muzzles and investigating alternatives to 1080 in pest control programs may be the key to reducing the incidence of future accidental poisonings.
Bibliography:ArticleID:AVJ474
istex:247A3FC146528640E440839DBE11690C0BD20FDA
ark:/67375/WNG-6J1RS9W2-D
ISSN:0005-0423
1751-0813
DOI:10.1111/j.1751-0813.2005.tb13296.x