Search Results - "Gogos, Joseph A"

Hippocampal–prefrontal input supports spatial encoding in working memory by Spellman, Timothy, Rigotti, Mattia, Ahmari, Susanne E., Fusi, Stefano, Gogos, Joseph A., Gordon, Joshua A.

“…Spatial working memory, the caching of behaviourally relevant spatial cues on a timescale of seconds, is a fundamental constituent of cognition. Although the…”
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Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome by Piskorowski, Rebecca A., Nasrallah, Kaoutsar, Diamantopoulou, Anastasia, Mukai, Jun, Hassan, Sami I., Siegelbaum, Steven A., Gogos, Joseph A., Chevaleyre, Vivien

“…Several neuropsychiatric disorders are associated with cognitive and social dysfunction. Postmortem studies of patients with schizophrenia have revealed…”
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De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia by Takata, Atsushi, Ionita-Laza, Iuliana, Gogos, Joseph A., Xu, Bin, Karayiorgou, Maria

“…We analyze de novo synonymous mutations identified in autism spectrum disorders (ASDs) and schizophrenia (SCZ) with potential impact on regulatory elements…”
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Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task by Tamura, Makoto, Spellman, Timothy J., Rosen, Andrew M., Gogos, Joseph A., Gordon, Joshua A.

“…Cross-frequency coupling supports the organization of brain rhythms and is present during a range of cognitive functions. However, little is known about…”
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Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia by Mukai, Jun, Tamura, Makoto, Fénelon, Karine, Rosen, Andrew M, Spellman, Timothy J, Kang, Rujun, MacDermott, Amy B, Karayiorgou, Maria, Gordon, Joshua A, Gogos, Joseph A

“…22q11.2 deletion carriers show specific cognitive deficits, and ∼30% of them develop schizophrenia. One of the disrupted genes is ZDHHC8, which encodes for a…”
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Altered Cortical Ensembles in Mouse Models of Schizophrenia by Hamm, Jordan P., Peterka, Darcy S., Gogos, Joseph A., Yuste, Rafael

“…In schizophrenia, brain-wide alterations have been identified at the molecular and cellular levels, yet how these phenomena affect cortical circuit activity…”
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Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a Candidate Susceptibility Gene by Takata, Atsushi, Xu, Bin, Ionita-Laza, Iuliana, Roos, J. Louw, Gogos, Joseph A., Karayiorgou, Maria

“…Loss-of-function (LOF) (i.e., nonsense, splice site, and frameshift) variants that lead to disruption of gene function are likely to contribute to the etiology…”
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Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia by Gogos, Joseph A, Gordon, Joshua A, Sigurdsson, Torfi, Stark, Kimberly L, Karayiorgou, Maria

“…Abnormalities in functional connectivity between brain areas have been postulated as an important pathophysiological mechanism underlying schizophrenia. In…”
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Developmental Inhibition of Gsk3 Rescues Behavioral and Neurophysiological Deficits in a Mouse Model of Schizophrenia Predisposition by Tamura, Makoto, Mukai, Jun, Gordon, Joshua A., Gogos, Joseph A.

“…While the genetic basis of schizophrenia is increasingly well characterized, novel treatments will require establishing mechanistic relationships between…”
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Derepression of a Neuronal Inhibitor due to miRNA Dysregulation in a Schizophrenia-Related Microdeletion by Xu, Bin, Hsu, Pei-Ken, Stark, Kimberly L., Karayiorgou, Maria, Gogos, Joseph A.

“…22q11.2 microdeletions result in specific cognitive deficits and schizophrenia. Analysis of Df(16)A+/− mice, which model this microdeletion, revealed…”
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De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia by Xu, Bin, Ionita-Laza, Iuliana, Roos, J Louw, Boone, Braden, Woodrick, Scarlet, Sun, Yan, Levy, Shawn, Gogos, Joseph A, Karayiorgou, Maria

“…Maria Karayiorgou, Joseph Gogos and colleagues report exome sequencing of 231 individuals with schizophrenia and their unaffected parents. They observed an…”
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Reset of hippocampal–prefrontal circuitry facilitates learning by Park, Alan J., Harris, Alexander Z., Martyniuk, Kelly M., Chang, Chia-Yuan, Abbas, Atheir I., Lowes, Daniel C., Kellendonk, Christoph, Gogos, Joseph A., Gordon, Joshua A.

“…The ability to rapidly adapt to novel situations is essential for survival, and this flexibility is impaired in many neuropsychiatric disorders 1 . Thus,…”
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Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice by Mukai, Jun, Cannavò, Enrico, Crabtree, Gregg W., Sun, Ziyi, Diamantopoulou, Anastasia, Thakur, Pratibha, Chang, Chia-Yuan, Cai, Yifei, Lomvardas, Stavros, Takata, Atsushi, Xu, Bin, Gogos, Joseph A.

“…SETD1A, a lysine-methyltransferase, is a key schizophrenia susceptibility gene. Mice carrying a heterozygous loss-of-function mutation of the orthologous gene…”
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Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setd1a+/− Mice by Hamm, Jordan P., Shymkiv, Yuriy, Mukai, Jun, Gogos, Joseph A., Yuste, Rafael

“…A breakdown of synchrony within neuronal ensembles leading to destabilization of network “attractors” could be a defining aspect of neuropsychiatric diseases…”
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The abiding relevance of mouse models of rare mutations to psychiatric neuroscience and therapeutics by Gogos, Joseph A., Crabtree, Gregg, Diamantopoulou, Anastasia

“…Studies using powerful family-based designs aided by large scale case-control studies, have been instrumental in cracking the genetic complexity of the…”
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Neurocognitive and Perceptual Processing in Genetic Mouse Models of Schizophrenia: Emerging Lessons by Diamantopoulou, Anastasia, Gogos, Joseph A.

“…During the past two decades, the number of animal models of psychiatric disorders has grown exponentially. Of these, genetic animal models that are modeled…”
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Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition by Rummell, Brian P., Bikas, Solmaz, Babl, Susanne S., Gogos, Joseph A., Sigurdsson, Torfi

“…The ability to distinguish sensations that are self-generated from those caused by external events is disrupted in schizophrenia patients. However, the neural…”
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S-Nitrosylation and S-Palmitoylation Reciprocally Regulate Synaptic Targeting of PSD-95 by Ho, Gary P.H., Selvakumar, Balakrishnan, Mukai, Jun, Hester, Lynda D., Wang, Yuxuan, Gogos, Joseph A., Snyder, Solomon H.

“…PSD-95, a principal scaffolding component of the postsynaptic density, is targeted to synapses by palmitoylation, where it couples NMDA receptor stimulation to…”
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Diverse types of genetic variation converge on functional gene networks involved in schizophrenia by Gilman, Sarah R, Chang, Jonathan, Xu, Bin, Bawa, Tejdeep S, Gogos, Joseph A, Karayiorgou, Maria, Vitkup, Dennis

“…The authors use a computational approach (NETBAG+) to integrate and analyze diverse genetic data and apply this to study schizophrenia-associated genetic…”
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The Genetic Architecture of Schizophrenia: New Mutations and Emerging Paradigms by Rodriguez-Murillo, Laura, Gogos, Joseph A, Karayiorgou, Maria

“…Although a genetic component of schizophrenia has been acknowledged for a long time, the underlying architecture of the genetic risk remains a contentious…”
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