Search Results - "Goggin, P. M."

High-resolution 3D imaging of osteocytes and computational modelling in mechanobiology: insights on bone development, ageing, health and disease by Goggin, P M, Zygalakis, K C, Oreffo, R O, Schneider, P

“…Osteocytes are involved in mechanosensation and mechanotransduction in bone and hence, are key to bone adaptation in response to development, ageing and…”
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Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial by Gordon, J N, Trebble, T M, Ellis, R D, Duncan, H D, Johns, T, Goggin, P M

“…Background: Proinflammatory cytokines, especially tumour necrosis factor α (TNF-α), play a prominent role in the pathogenesis of cancer cachexia. Thalidomide,…”
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Cancer cachexia by Gordon, J.N., Green, S.R., Goggin, P.M.

“…Cancer cachexia is a severe debilitating disorder for which there are currently few therapeutic options. It is driven by the release of pro-inflammatory…”
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Thalidomide and its derivatives: emerging from the wilderness by Gordon, J N, Goggin, P M

“…Forty years on from its worldwide withdrawal, thalidomide is currently undergoing a remarkable renaissance as a novel and powerful immunomodulatory agent. Over…”
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Relation of Helicobacter pylori infection and coronary heart disease by Mendall, M. A., Goggin, P. M., Molineaux, N., Levy, J., Toosy, T., Strachan, D., Camm, A. J., Northfield, T. C.

“…BACKGROUND--There is evidence suggesting that early life experience may influence adult risk of coronary heart disease (CHD). Chronic bacterial infections have…”
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Childhood living conditions and Helicobacter pylori seropositivity in adult life by Mendall, M A, Goggin, P M, Molineaux, N, Levy, J, Toosy, T, Strachan, D, Northfield, T C

“…Infection with Helicobacter pylori increases an individual's risk of peptic ulceration and gastric cancer. In the developed world, prevalence of infection…”
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Enteral nutrition by nasojejunal tube in hyperemesis gravidarum by PEARCE, C.B., COLLETT, J., GOGGIN, P.M., Duncan, H.D.

“…We describe two cases in which self-propelling, blind placed nasojejunal tubes were placed in severe hyperemesis gravidarum. This method provides an…”
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Growth in infancy, infant feeding, childhood living conditions, and Helicobacter pylori infection at age 70 by Fall, C H D, Goggin, P M, Hawtin, P, Fine, D, Duggleby, S

“…AIM To examine childhood correlates ofHelicobacter pylori infection in adults. DESIGN Follow up study of men and women whose birth weight, weight at age 1…”
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Metal stents improve dysphagia, nutrition and survival in malignant oesophageal stenosis: a randomized controlled trial comparing modified Gianturco Z-stents with plastic Atkinson tubes by Roseveare, C D, Patel, P, Simmonds, N, Goggin, P M, Kimble, J, Shepherd, H A

“…To compare modified Gianturco metal stents with plastic Atkinson tubes in the palliation of malignant dysphagia. Patient single-blind, multi-centre…”
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Determinants of pregnancy heartburn by Marrero, J M, Goggin, P M, de Caestecker, J S, Pearce, J M, Maxwell, J D

“…To study the prevalence and severity of reflux symptoms in pregnancy. Self-administered questionnaire detailing age, race, gestational age, parity, weight,…”
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Prevalence of Helicobacter pylori infection and its effect on symptoms and non-steroidal anti-inflammatory drug induced gastrointestinal damage in patients with rheumatoid arthritis by Goggin, P M, Collins, D A, Jazrawi, R P, Jackson, P A, Corbishley, C M, Bourke, B E, Northfield, T C

“…Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter (H pylori) are both associated with an increased risk of peptic ulceration and gastropathy. It…”
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Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid by Jazrawi, R P, de Caestecker, J S, Goggin, P M, Britten, A J, Joseph, A E, Maxwell, J D, Northfield, T C

“…Ursodeoxycholic acid (UDCA) is clinically beneficial in chronic cholestatic liver disease, but the underlying mechanisms are unclear. It has been suggested…”
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The ‘cut and push’ method of percutaneous endoscopic gastrostomy tube removal by Pearce, C.B., Goggin, P.M., Collett, J., Smith, L., Duncan, H.D.

“…Background and aims: The standard method of removing percutaneous endoscopic gastrostomy tubes is by gastroscopy. This has implications for endoscopy time and…”
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CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-α and MMP-3 production in patients with inflammatory bowel disease by Gordon, J N, Prothero, J D, Thornton, C A, Pickard, K M, Di Sabatino, A, Goggin, P M, Pender, S L, Macdonald, T T

“…Thalidomide, one of whose activities is to inhibit Tumour Necrosis Factor (TNF)-α production, has been reported to be an effective treatment for refractory…”
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Colonic lymphoid hyperplasia in melanosis coli by Pearce, C B, Martin, H, Duncan, H D, Goggin, P M, Poller, D N

“…We describe the case of a patient with Rett syndrome, a syndrome characterized by progressive infant encephalopathy, developmental delay, dementia, autism,…”
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Surface hydrophobicity of gastric mucosa in peptic ulcer disease. Relationship to gastritis and Campylobacter pylori infection by Spychal, R T, Goggin, P M, Marrero, J M, Saverymuttu, S H, Yu, C W, Corbishley, C M, Maxwell, J D, Northfield, T C

“…The hydrophobicity of biopsy specimens of gastric mucosa in 228 dyspeptic subjects undergoing diagnostic endoscopy was assessed by measuring the…”
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Surface hydrophobicity of gastric mucosa in Helicobacter pylori infection: effect of clearance and eradication by Goggin, P M, Marrero, J M, Spychal, R T, Jackson, P A, Corbishley, C M, Northfield, T C

“…Surface hydrophobicity of the gastric mucosa is reduced in peptic ulcer disease and Helicobacter pylori infection. This abnormality may be caused by H. pylori…”
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Intrahepatic biliary cholesterol and phospholipid transport in humans: effect of obesity and cholesterol cholelithiasis by Ahmed, H.A., Jazrawi, R.P., Goggin, P.M., Dormandy, J, Northfield, T C

“…The mode of transport of biliary lipids within the hepatocyte and the role of the bile canalicular membrane (BCM) in biliary lipid secretion are not well…”
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Factors affecting gastric mucosal hydrophobicity in man by Goggin, P M, Northfield, T C, Spychal, R T

“…Contact angle measurements in animal studies have demonstrated that gastric mucosa has a relatively hydrophobic surface. We have developed and validated a…”
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Thalidomide in the treatment of cancer cachexia : a randomised placebo controlled trial. Commentary by STROUD, M, GORDON, J. N, TREBBLE, T. M, ELLIS, R. D, DUNCAN, H. D, JOHNS, T, GOGGIN, P. M

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