Search Results - "Goggin, M"

ESCHR: a hyperparameter-randomized ensemble approach for robust clustering across diverse datasets by Goggin, Sarah M, Zunder, Eli R

“…Clustering is widely used for single-cell analysis, but current methods are limited in accuracy, robustness, ease of use, and interpretability. To address…”
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High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human by Wang, Xinchen, He, Liang, Goggin, Sarah M., Saadat, Alham, Wang, Li, Sinnott-Armstrong, Nasa, Claussnitzer, Melina, Kellis, Manolis

“…Genome-wide epigenomic maps have revealed millions of putative enhancers and promoters, but experimental validation of their function and high-resolution…”
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Violation of the Leggett-Garg inequality with weak measurements of photons by Goggin, M. E., Almeida, M. P., Barbieri, M., Lanyon, B. P., O'Brien, J. L, White, A. G., Pryde, G. J., Aharonov, Yakir

“…By weakly measuring the polarization of a photon between two strong polarization measurements, we experimentally investigate the correlation between the…”
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Towards quantum chemistry on a quantum computer by Lanyon, B. P., Whitfield, J. D., Gillett, G. G., Goggin, M. E., Almeida, M. P., Kassal, I., Biamonte, J. D., Mohseni, M., Powell, B. J., Barbieri, M., Aspuru-Guzik, A., White, A. G.

“…Exact first-principles calculations of molecular properties are currently intractable because their computational cost grows exponentially with both the number…”
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Culture of primary ciliary dyskinesia epithelial cells at air-liquid interface can alter ciliary phenotype but remains a robust and informative diagnostic aid by Hirst, Robert A, Jackson, Claire L, Coles, Janice L, Williams, Gwyneth, Rutman, Andrew, Goggin, Patricia M, Adam, Elizabeth C, Page, Anthony, Evans, Hazel J, Lackie, Peter M, O'Callaghan, Christopher, Lucas, Jane S

“…The diagnosis of primary ciliary dyskinesia (PCD) requires the analysis of ciliary function and ultrastructure. Diagnosis can be complicated by secondary…”
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Identification of Unique Metabolites of the Designer Opioid Furanyl Fentanyl by Goggin, Melissa M, Nguyen, An, Janis, Gregory C

“…The illicit drug market has seen an increase in designer opioids, including fentanyl and methadone analogs, and other structurally unrelated opioid agonists…”
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Accuracy of diagnostic testing in primary ciliary dyskinesia by Jackson, Claire L, Behan, Laura, Collins, Samuel A, Goggin, Patricia M, Adam, Elizabeth C, Coles, Janice L, Evans, Hazel J, Harris, Amanda, Lackie, Peter, Packham, Samantha, Page, Anton, Thompson, James, Walker, Woolf T, Kuehni, Claudia, Lucas, Jane S

“…Diagnosis of primary ciliary dyskinesia (PCD) lacks a "gold standard" test and is therefore based on combinations of tests including nasal nitric oxide (nNO),…”
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High-resolution 3D imaging of osteocytes and computational modelling in mechanobiology: insights on bone development, ageing, health and disease by Goggin, P M, Zygalakis, K C, Oreffo, R O, Schneider, P

“…Osteocytes are involved in mechanosensation and mechanotransduction in bone and hence, are key to bone adaptation in response to development, ageing and…”
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Two-photon quantum walks in an elliptical direct-write waveguide array by Owens, J O, Broome, M A, Biggerstaff, D N, Goggin, M E, Fedrizzi, A, Linjordet, T, Ams, M, Marshall, G D, Twamley, J, Withford, M J, White, A G

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Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial by Gordon, J N, Trebble, T M, Ellis, R D, Duncan, H D, Johns, T, Goggin, P M

“…Background: Proinflammatory cytokines, especially tumour necrosis factor α (TNF-α), play a prominent role in the pathogenesis of cancer cachexia. Thalidomide,…”
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Acute kidney injury during treatment for latent tuberculous infection with rifampin by Wortham, J. M., Goggin, M., Mora, C., Vandehey, L., Manangan, L., Powell, K. M.

“…Treatment for latent tuberculous infection (LTBI) is a key strategy for the elimination of tuberculosis. Rare adverse reactions associated with LTBI treatment…”
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Anodyne by Design; Measuring the Prevalence of Esoteric Designer Opioids in Pain Management Patients by Goggin, Melissa M, Gozum, Stephanie D, Miller, Anna, Janis, Gregory C

“…Abstract The recent increase in illicit opioids sold on the black market, cut into heroin and masqueraded as prescription pills prompts a significant public…”
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Partitioning, bioavailability, and toxicity of the pyrethroid insecticide cypermethrin in sediments by Maund, Steve J., Hamer, Mick J., Lane, Mike C. G., Farrelly, Eamonn, Rapley, Jean H., Goggin, Una M., Gentle, Wendy E.

“…The partitioning, bioavailability, and toxicity of cypermethrin in water–sediment systems was investigated. Cypermethrin adsorbed extensively and rapidly, with…”
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A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications by Katsamenis, Orestis L, Basford, Philip J, Robinson, Stephanie K, Boardman, Richard P, Konstantinopoulou, Elena, Lackie, Peter M, Page, Anton, Ratnayaka, J Arjuna, Goggin, Patricia M, Thomas, Gareth J, Cox, Simon J, Sinclair, Ian, Schneider, Philipp

“…The University of Southampton, in collaboration with the University Hospital Southampton (UHS) NHS Foundation Trust and industrial partners, has been at the…”
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A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications by Katsamenis, Orestis L., Basford, Philip J., Robinson, Stephanie K., Boardman, Richard P., Konstantinopoulou, Elena, Lackie, Peter M., Page, Anton, Ratnayaka, J. Arjuna, Goggin, Patricia M., Thomas, Gareth J., Cox, Simon J., Sinclair, Ian, Schneider, Philipp

“…Background The University of Southampton, in collaboration with the University Hospital Southampton (UHS) NHS Foundation Trust and industrial partners, has…”
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Ciliary Beat Pattern Analysis Below 37°C May Increase Risk of Primary Ciliary Dyskinesia Misdiagnosis by Jackson, Claire L., PhD, Goggin, Patricia M., MMedSci, Lucas, Jane S., PhD

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First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models by Kelly, Julie A., Boyle, Noreen T., Cole, Natalie, Slator, Gillian R., Colivicchi, M. Alessandra, Stefanini, Chiara, Gobbo, Oliviero L., Scalabrino, Gaia A., Ryan, Sinead M., Elamin, Marwa, Walsh, Cathal, Vajda, Alice, Goggin, Margaret M., Campbell, Matthew, Mash, Deborah C., O'Mara, Shane M., Brayden, David J., Callanan, John J., Tipton, Keith F., Della Corte, Laura, Hunter, Jackie, O'Boyle, Kathy M., Williams, Carvell H., Hardiman, Orla

“…JAK4D, a first-in-class thyrotropin-releasing hormone (TRH)-based compound, is a prospective therapeutic candidate offering a multifaceted approach to treating…”
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Cancer cachexia by Gordon, J.N., Green, S.R., Goggin, P.M.

“…Cancer cachexia is a severe debilitating disorder for which there are currently few therapeutic options. It is driven by the release of pro-inflammatory…”
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Distinct proliferative and transcriptional effects of the D-type cyclins in vivo by Mullany, Lisa K., White, Peter, Hanse, Eric A., Nelsen, Christopher J., Goggin, Melissa M., Mullany, Joseph E., Anttila, Chelsea K., Greenbaum, Linda E., Kaestner, Klaus H., Albrecht, Jeffrey H.

“…The D-type cyclins (D1, D2, and D3) are components of the cell cycle machinery and govern progression through G1 phase in response to extracellular signals…”
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Survival of bacteria on the ocular surface following double application of povidone-iodine before cataract surgery by Stranz, C V, Fraenkel, G E, Butcher, A R, Esterman, A J, Goggin, M J

“…Aims This study assessed the effectiveness of one vs two applications of povidone-iodine in decontaminating the eye before cataract surgery. Methods This was a…”
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