Search Results - "Goff, Loyal A"

Linking RNA biology to lncRNAs by Goff, Loyal A, Rinn, John L

“…The regulatory potential of RNA has never ceased to amaze: from RNA catalysis, to RNA-mediated splicing, to RNA-based silencing of an entire chromosome during…”
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DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex by Molyneaux, Bradley J, Goff, Loyal A, Brettler, Andrea C, Chen, Hsu-Hsin, Hrvatin, Siniša, Rinn, John L, Arlotta, Paola

“…Neuronal development requires a complex choreography of transcriptional decisions to obtain specific cellular identities. Realizing the ultimate goal of…”
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The MicroRNA miR-181 Is a Critical Cellular Metabolic Rheostat Essential for NKT Cell Ontogenesis and Lymphocyte Development and Homeostasis by Henao-Mejia, Jorge, Williams, Adam, Goff, Loyal A., Staron, Matthew, Licona-Limón, Paula, Kaech, Susan M., Nakayama, Maki, Rinn, John L., Flavell, Richard A.

“…Regulation of metabolic pathways in the immune system provides a mechanism to actively control cellular function, growth, proliferation, and survival. Here, we…”
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Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification by Clark, Brian S., Stein-O’Brien, Genevieve L., Shiau, Fion, Cannon, Gabrielle H., Davis-Marcisak, Emily, Sherman, Thomas, Santiago, Clayton P., Hoang, Thanh V., Rajaii, Fatemeh, James-Esposito, Rebecca E., Gronostajski, Richard M., Fertig, Elana J., Goff, Loyal A., Blackshaw, Seth

“…Precise temporal control of gene expression in neuronal progenitors is necessary for correct regulation of neurogenesis and cell fate specification. However,…”
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Enter the Matrix: Factorization Uncovers Knowledge from Omics by Stein-O’Brien, Genevieve L., Arora, Raman, Culhane, Aedin C., Favorov, Alexander V., Garmire, Lana X., Greene, Casey S., Goff, Loyal A., Li, Yifeng, Ngom, Aloune, Ochs, Michael F., Xu, Yanxun, Fertig, Elana J.

“…Omics data contain signals from the molecular, physical, and kinetic inter- and intracellular interactions that control biological systems. Matrix…”
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Normal and Sjogren's syndrome models of the murine lacrimal gland studied at single-cell resolution by Rattner, Amir, Heng, Jacob S, Winer, Briana L, Goff, Loyal A, Nathans, Jeremy

“…The lacrimal gland is of central interest in ophthalmology both as the source of the aqueous component of tear fluid and as the site of autoimmune pathology in…”
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Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre by Hacisuleyman, Ezgi, Goff, Loyal A, Trapnell, Cole, Williams, Adam, Henao-Mejia, Jorge, Sun, Lei, McClanahan, Patrick, Hendrickson, David G, Sauvageau, Martin, Kelley, David R, Morse, Michael, Engreitz, Jesse, Lander, Eric S, Guttman, Mitch, Lodish, Harvey F, Flavell, Richard, Raj, Arjun, Rinn, John L

“…A long intergenic noncoding RNA, Firre, is now shown to localize to a domain across its own chromosomal locus and to distinct interacting transchromosomal loci…”
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Ret deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system development by Vincent, Elizabeth, Chatterjee, Sumantra, Cannon, Gabrielle H, Auer, Dallas, Ross, Holly, Chakravarti, Aravinda, Goff, Loyal A

“…The receptor tyrosine kinase RET plays a critical role in the fate specification of enteric neural crest-derived cells (ENCDCs) during enteric nervous system…”
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projectR: an R/Bioconductor package for transfer learning via PCA, NMF, correlation and clustering by Sharma, Gaurav, Colantuoni, Carlo, Goff, Loyal A, Fertig, Elana J, Stein-O’Brien, Genevieve

“…Abstract Motivation Dimension reduction techniques are widely used to interpret high-dimensional biological data. Features learned from these methods are used…”
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Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells by Sabbagh, Mark F, Heng, Jacob S, Luo, Chongyuan, Castanon, Rosa G, Nery, Joseph R, Rattner, Amir, Goff, Loyal A, Ecker, Joseph R, Nathans, Jeremy

“…Vascular endothelial cell (EC) function depends on appropriate organ-specific molecular and cellular specializations. To explore genomic mechanisms that…”
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Pumping the brakes on RNA velocity by understanding and interpreting RNA velocity estimates by Zheng, Shijie C, Stein-O'Brien, Genevieve, Boukas, Leandros, Goff, Loyal A, Hansen, Kasper D

“…RNA velocity analysis of single cells offers the potential to predict temporal dynamics from gene expression. In many systems, RNA velocity has been observed…”
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Long noncoding RNAs regulate adipogenesis by Sun, Lei, Goff, Loyal A., Trapnell, Cole, Alexander, Ryan, Lo, Kinyui Alice, Hacisuleyman, Ezgi, Sauvageau, Martin, Tazon-Vega, Barbara, Kelley, David R., Hendrickson, David G., Yuan, Bingbing, Kellis, Manolis, Lodish, Harvey F., Rinn, John L.

“…The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes,…”
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DNMT1-interacting RNAs block gene-specific DNA methylation by Di Ruscio, Annalisa, Ebralidze, Alexander K., Benoukraf, Touati, Amabile, Giovanni, Goff, Loyal A., Terragni, Jolyon, Figueroa, Maria Eugenia, De Figueiredo Pontes, Lorena Lobo, Alberich-Jorda, Meritxell, Zhang, Pu, Wu, Mengchu, D’Alò, Francesco, Melnick, Ari, Leone, Giuseppe, Ebralidze, Konstantin K., Pradhan, Sriharsa, Rinn, John L., Tenen, Daniel G.

“…DNA methylation was first described almost a century ago; however, the rules governing its establishment and maintenance remain elusive. Here we present data…”
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Differential regulation of microRNA stability by Bail, Sophie, Swerdel, Mavis, Liu, Hudan, Jiao, Xinfu, Goff, Loyal A, Hart, Ronald P, Kiledjian, Megerditch

“…MicroRNAs (miRNAs) are endogenous single-stranded RNA molecules of about 21 nucleotides in length that are fundamental post-transcriptional regulators of gene…”
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Universal prediction of cell-cycle position using transfer learning by Zheng, Shijie C, Stein-O'Brien, Genevieve, Augustin, Jonathan J, Slosberg, Jared, Carosso, Giovanni A, Winer, Briana, Shin, Gloria, Bjornsson, Hans T, Goff, Loyal A, Hansen, Kasper D

“…The cell cycle is a highly conserved, continuous process which controls faithful replication and division of cells. Single-cell technologies have enabled…”
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Parallel Social Information Processing Circuits Are Differentially Impacted in Autism by Lewis, Eastman M., Stein-O’Brien, Genevieve L., Patino, Alejandra V., Nardou, Romain, Grossman, Cooper D., Brown, Matthew, Bangamwabo, Bidii, Ndiaye, Ndeye, Giovinazzo, Daniel, Dardani, Ian, Jiang, Connie, Goff, Loyal A., Dölen, Gül

“…Parallel processing circuits are thought to dramatically expand the network capabilities of the nervous system. Magnocellular and parvocellular oxytocin…”
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Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain by Goff, Loyal A., Groff, Abigail F., Sauvageau, Martin, Trayes-Gibson, Zachary, Sanchez-Gomez, Diana B., Morse, Michael, Martin, Ryan D., Elcavage, Lara E., Liapis, Stephen C., Gonzalez-Celeiro, Meryem, Plana, Olivia, Li, Eric, Gerhardinger, Chiara, Tomassy, Giulio S., Arlotta, Paola, Rinn, John L.

“…Long noncoding RNAs (lncRNAs) have been implicated in numerous cellular processes including brain development. However, the in vivo expression dynamics and…”
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A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome by Benjamin, Joel S., Pilarowski, Genay O., Carosso, Giovanni A., Zhang, Li, Huso, David. L., Goff, Loyal A., Vernon, Hilary J., Hansen, Kasper D., Bjornsson, Hans T.

“…Kabuki syndrome is a Mendelian intellectual disability syndrome caused by mutations in either of two genes (KMT2D and KDM6A) involved in chromatin…”
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Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution by Heng, Jacob S., Rattner, Amir, Stein-O’Brien, Genevieve L., Winer, Briana L., Jones, Bryan W., Vernon, Hilary J., Goff, Loyal A., Nathans, Jeremy

“…The mammalian CNS is capable of tolerating chronic hypoxia, but cell type-specific responses to this stress have not been systematically characterized. In the…”
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Odorant-receptor-mediated regulation of chemosensory gene expression in the malaria mosquito Anopheles gambiae by Maguire, Sarah E., Afify, Ali, Goff, Loyal A., Potter, Christopher J.

“…Mosquitoes locate and approach humans based on the activity of odorant receptors (ORs) expressed on olfactory receptor neurons (ORNs). Olfactogenetic…”
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