Search Results - "Goetzl, Edward J"

High complement levels in astrocyte‐derived exosomes of Alzheimer disease by Goetzl, Edward J., Schwartz, Janice B., Abner, Erin L., Jicha, Gregory A., Kapogiannis, Dimitrios

“…Objective Astrocytes fulfill neuronal trophic roles normally, but are transformed in Alzheimer disease (AD) into A1‐type reactive astrocytes that may destroy…”
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Cargo proteins of plasma astrocyte‐derived exosomes in Alzheimer's disease by Goetzl, Edward J., Mustapic, Maja, Kapogiannis, Dimitrios, Eitan, Erez, Lobach, Irina V., Goetzl, Laura, Schwartz, Janice B., Miller, Bruce L.

“…ABSTRACT Efficient intercellular transfer of RNAs, proteins, and lipids as protected exosomal cargo has been demonstrated in the CNS, but distinct physiologic…”
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Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease by Goetzl, Edward J., Kapogiannis, Dimitrios, Schwartz, Janice B., Lobach, Iryna V., Goetzl, Laura, Abner, Erin L., Jicha, Gregory A., Karydas, Anna M., Boxer, Adam, Miller, Bruce L.

“…ABSTRACT Synaptic dysfunction occurs early in senile dementias, presumably as a result of decreased levels of functional synaptic proteins as found in…”
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Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural‐derived blood exosomes of preclinical Alzheimer's disease by Kapogiannis, Dimitrios, Boxer, Adam, Schwartz, Janice B., Abner, Erin L., Biragyn, Arya, Masharani, Umesh, Frassetto, Lynda, Petersen, Ronald C., Miller, Bruce L., Goetzl, Edward J.

“…ABSTRACT Insulin resistance causes diminished glucose uptake in similar regions of the brain in Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2)…”
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Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study by Fiandaca, Massimo S, Kapogiannis, Dimitrios, Mapstone, Mark, Boxer, Adam, Eitan, Erez, Schwartz, Janice B, Abner, Erin L, Petersen, Ronald C, Federoff, Howard J, Miller, Bruce L, Goetzl, Edward J

“…Abstract Background Proteins pathogenic in Alzheimer's disease (AD) were extracted from neurally derived blood exosomes and quantified to develop biomarkers…”
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Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes by Mustapic, Maja, Eitan, Erez, Werner, Jr, John K, Berkowitz, Sean T, Lazaropoulos, Michael P, Tran, Joyce, Goetzl, Edward J, Kapogiannis, Dimitrios

“…Our team has been a pioneer in harvesting extracellular vesicles (EVs) enriched for neuronal origin from peripheral blood and using them as a biomarker…”
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Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network by Goetzl, Edward J, Rosen, Hugh

“…Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that transmits signals through a family of G-protein-coupled receptors to control…”
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Neural cell‐derived plasma exosome protein abnormalities implicate mitochondrial impairment in first episodes of psychosis by Goetzl, Edward J., Srihari, Vinod H., Guloksuz, Sinan, Ferrara, Maria, Tek, Cenk, Heninger, George R.

“…Neuroprotective and other functional proteins of mitochondria were quantified in extracts of plasma neural‐derived exosomes from ten first‐episode psychosis…”
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Traumatic brain injury increases plasma astrocyte‐derived exosome levels of neurotoxic complement proteins by Goetzl, Edward J., Yaffe, Kristine, Peltz, Carrie B., Ledreux, Aurélie, Gorgens, Kim, Davidson, Bradley, Granholm, Ann‐Charlotte, Mustapic, Maja, Kapogiannis, Dimitrios, Tweedie, David, Greig, Nigel H.

“…Possible involvement of complement (C) systems in the pathogenesis of traumatic brain injury (TBI) was investigated by quantifying Cproteins in plasma…”
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Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile by Winston, Charisse N, Goetzl, Edward J, Akers, Johnny C, Carter, Bob S, Rockenstein, Edward M, Galasko, Douglas, Masliah, Eliezer, Rissman, Robert A

“…Abstract Introduction Levels of Alzheimer's disease (AD)-related proteins in plasma neuronal derived exosomes (NDEs) were quantified to identify biomarkers for…”
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Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia by Winston, Charisse N., Goetzl, Edward J., Schwartz, Janice B., Elahi, Fanny M., Rissman, Robert A.

“…Levels of complement proteins (CPs) in plasma astrocyte-derived exosomes (ADEs) that are abnormal in Alzheimer's disease (AD) have not been assessed in mild…”
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Mitochondrial Electron Transport Chain Protein Abnormalities Detected in Plasma Extracellular Vesicles in Alzheimer’s Disease by Yao, Pamela J., Eren, Erden, Goetzl, Edward J., Kapogiannis, Dimitrios

“…Mitochondria provide energy to neurons through oxidative phosphorylation and eliminate Reactive Oxygen Species (ROS) through Superoxide Dismutase 1 (SOD1)…”
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Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury by Tweedie, David, Karnati, Hanuma Kumar, Mullins, Roger, Pick, Chaim G, Hoffer, Barry J, Goetzl, Edward J, Kapogiannis, Dimitrios, Greig, Nigel H

“…Traumatic brain injury (TBI) is a serious global health problem, many individuals live with TBI-related neurological dysfunction. A lack of biomarkers of TBI…”
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Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer's Disease Patients Effect Complement-Mediated Neurotoxicity by Nogueras-Ortiz, Carlos J, Mahairaki, Vasiliki, Delgado-Peraza, Francheska, Das, Debamitra, Avgerinos, Konstantinos, Eren, Erden, Hentschel, Matthew, Goetzl, Edward J, Mattson, Mark P, Kapogiannis, Dimitrios

“…We have previously shown that blood astrocytic-origin extracellular vesicles (AEVs) from Alzheimer's disease (AD) patients contain high complement levels. To…”
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Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome by Hamlett, Eric D, Goetzl, Edward J, Ledreux, Aurélie, Vasilevko, Vitaly, Boger, Heather A, LaRosa, Angela, Clark, David, Carroll, Steven L, Carmona-Iragui, María, Fortea, Juan, Mufson, Elliott J, Sabbagh, Marwan, Mohammed, Abdul H, Hartley, Dean, Doran, Eric, Lott, Ira T, Granholm, Ann-Charlotte

“…Abstract Introduction Individuals with Down syndrome (DS) exhibit Alzheimer's disease (AD) neuropathology and dementia early in life. Blood biomarkers of AD…”
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Decreased mitochondrial electron transport proteins and increased complement mediators in plasma neural-derived exosomes of early psychosis by Goetzl, Edward J., Srihari, Vinod H., Guloksuz, Sinan, Ferrara, Maria, Tek, Cenk, Heninger, George R.

“…Potentially neurotoxic systems involved in traumatic and degenerative diseases of the brain were assessed in acute psychosis. Astrocyte-derived exosomes (ADEs)…”
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Neuronal and Astrocytic Extracellular Vesicle Biomarkers in Blood Reflect Brain Pathology in Mouse Models of Alzheimer's Disease by Delgado-Peraza, Francheska, Nogueras-Ortiz, Carlos J, Volpert, Olga, Liu, Dong, Goetzl, Edward J, Mattson, Mark P, Greig, Nigel H, Eitan, Erez, Kapogiannis, Dimitrios

“…Circulating neuronal extracellular vesicles (NEVs) of Alzheimer's disease (AD) patients show high Tau and β-amyloid (Aβ) levels, whereas their astrocytic EVs…”
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Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy by Goetzl, Edward J, Ledreux, Aurélie, Granholm, Ann-Charlotte, Elahi, Fanny M, Goetzl, Laura, Hiramoto, Jade, Kapogiannis, Dimitrios

“…The recent recognition that Alzheimer disease-like pathology may be found in chronic traumatic encephalopathy (CTE) even after acute mild traumatic brain…”
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Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease by Delgado-Peraza, Francheska, Nogueras-Ortiz, Carlos, Simonsen, Anja Hviid, Knight, De'Larrian DeAnté, Yao, Pamela J, Goetzl, Edward J, Jensen, Camilla Steen, Høgh, Peter, Gottrup, Hanne, Vestergaard, Karsten, Hasselbalch, Steen Gregers, Kapogiannis, Dimitrios

“…Neuron-derived extracellular vesicles (NDEVs) in blood may be used to derive biomarkers for the effects of exercise in Alzheimer's disease (AD). For this…”
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Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia by Zhang, Jianqing, Honbo, Norman, Goetzl, Edward J, Chatterjee, Kanu, Karliner, Joel S, Gray, Mary O

“…Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that serves as a key regulator of cellular differentiation and survival. Immune stimuli…”
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