Search Results - "Goetze, M."

High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans by Goetze, Andrew M, Liu, Y Diana, Zhang, Zhongqi, Shah, Bhavana, Lee, Edward, Bondarenko, Pavel V, Flynn, Gregory C

“…Glycan structures attached to the CH2 domain of the Fc region of immunoglobulin G (IgG) are essential for specific effector functions but their role in…”
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Identification and quantification of host cell protein impurities in biotherapeutics using mass spectrometry by Schenauer, Matthew R., Flynn, Gregory C., Goetze, Andrew M.

“…Residual host cell proteins (HCPs) in biotherapeutics can present potential safety risks to patients or compromise product stability. As such, their levels are…”
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Comprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry by Zhang, Qingchun, Goetze, Andrew M, Cui, Huanchun, Wylie, Jenna, Trimble, Steve, Hewig, Art, Flynn, Gregory C

“…An advanced two-dimensional liquid chromatography/mass spectrometry platform was used to quantify individual host cell proteins (HCPs) present at various…”
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Rates and impact of human antibody glycation in vivo by Goetze, Andrew M, Liu, Y Diana, Arroll, Thomas, Chu, Lily, Flynn, Gregory C

“…Glycation of immunoglobulin G (IgG) can result from incubation with a reducing sugar in vitro or during circulation in vivo. Upon injection of a recombinantly…”
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Assessing monoclonal antibody product quality attribute criticality through clinical studies by Goetze, Andrew M., Schenauer, Matthew R., Flynn, Gregory C.

“…Recombinant therapeutic proteins, including antibodies, contain a variety of chemical and physical modifications. Great effort is expended during process and…”
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Profiling the effects of process changes on residual host cell proteins in biotherapeutics by mass spectrometry by Schenauer, Matthew R., Flynn, Gregory C., Goetze, Andrew M.

“…An advanced liquid chromatography/mass spectrometry (MS) platform was used to identify and quantify residual Escherichia coli host cell proteins (HCPs) in the…”
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N-terminal Glutamate to Pyroglutamate Conversion in Vivo for Human IgG2 Antibodies by Liu, Y. Diana, Goetze, Andrew M., Bass, Randal B., Flynn, Gregory C.

“…Therapeutic proteins contain a large number of post-translational modifications, some of which could potentially impact their safety or efficacy. In one of…”
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DOTATOC: a powerful new tool for receptor-mediated radionuclide therapy by Otte, A, Jermann, E, Behe, M, Goetze, M, Bucher, H C, Roser, H W, Heppeler, A, Mueller-Brand, J, Maecke, H R

“…This study presents the first successful use of a peptidic vector, DOTATOC, labelled with the beta-emitting radioisotope yttrium-90, for the treatment of a…”
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Characterization of the co-elution of host cell proteins with monoclonal antibodies during protein A purification by Zhang, Qingchun, Goetze, Andrew M., Cui, Huanchun, Wylie, Jenna, Tillotson, Ben, Hewig, Art, Hall, Michael P., Flynn, Gregory C.

“…Protein A chromatography is commonly used as the initial step for purifying monoclonal antibody biotherapeutics expressed in mammalian tissue culture cells…”
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A rapid, quantitative method for assessing axonal extension on biomaterial platforms by Cregg, Jared M, Wiseman, Sherri L, Pietrzak-Goetze, Nicole M, Smith, Martyn R, Jaroch, David B, Clupper, Daniel C, Gilbert, Ryan J

“…Measuring outgrowth of neuronal explants is critical in evaluating the ability of a biomaterial to act as a permissive substrate for neuronal adhesion and…”
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Trunk kinematics during walking in children and adult with cerebral palsy by Salami, F., Goetze, M., Musagara, A. Rehani, Wolf, S.I.

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Assessment of naturally occurring covalent and total dimer levels in human IgG1 and IgG2 by Yang, Jane, Goetze, Andrew M., Flynn, Gregory C.

“…•Low levels (<1%) of dimer can be measured on endogenous human IgG1 and IgG2.•About 0.4% of IgG2, but little IgG1, is in a covalent dimer form.•Covalent IgG2…”
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Ankle joint dorsi-plantar flexion and recurrence after femoral de-rotation osteotomy by Salami, F., Goetze, M., Thielen, M., Wolf, S.I.

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Rapid LC–MS screening for IgG Fc modifications and allelic variants in blood by Goetze, Andrew M., Zhang, Zhongqi, Liu, Ling, Jacobsen, Frederick W., Flynn, Gregory C.

“…► We demonstrate a rapid LC–MS method for profiling IgG Fc modifications and allelic variants in blood. ► Information is obtained at the haplotype level. ►…”
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IgG2 disulfide isoform conversion kinetics by Liu, Yaoqing Diana, Wang, Tian, Chou, Robert, Chen, Louise, Kannan, Gunasekaran, Stevenson, Riki, Goetze, Andrew M., Jiang, Xinzhao Grace, Huang, Gang, Dillon, Thomas M., Flynn, Gregory C.

“…► We describe a flow-through dialysis system to mimic blood redox chemistry. ► In vivo IgG2 disulfide isoform conversions can be accurately replicated in…”
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Determining heel center using functional calibration algorithms by Salami, F., Goetze, M., Leboucher, J., Campos, S., Hagmann, S., Wolf, S.I.

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Brain glucose utilization in systemic lupus erythematosus with neuropsychiatric symptoms: a controlled positron emission tomography study by Otte, A, Weiner, S M, Peter, H H, Mueller-Brand, J, Goetze, M, Moser, E, Gutfleisch, J, Hoegerle, S, Juengling, F D, Nitzsche, E U

“…In contrast to morphological imaging [such as magnetic resonance imaging (MRI) or computed tomography], functional imaging may be of advantage in the detection…”
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Focusing on functional knee parameter determination to develop a better clinical gait analysis protocol by Leboucher, J., Salami, F., Öztürk, O., Heitzmann, D.W.W., Götze, M., Dreher, Th, Wolf, S.I.

“…•Functional methods perform as well or better than conventional for KJA estimation.•Regression methods perform slightly better for KJC prediction.•DynaKAD,…”
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Analysis of testbeam data of the highly granular RPC-steel CALICE digital hadron calorimeter and validation of Geant4 Monte Carlo models by Chefdeville, M., Repond, J., Schlereth, J., Smith, J.R., Trojand, D., Xia, L., Zhang, Q., Apostolakis, J., Grefe, C., Ivantchenko, V., Folger, G., Ribon, A., Uzhinskiy, V., Blazey, G.C., Dyshkant, A., Francis, K., Zutshi, V., Bach, O., Bocharnikov, V., Brianne, E., Gadow, K., Göttlicher, P., Hartbrich, O., Heuchel, D., Krivan, F., Krüger, K., Kvasnicka, J., Lu, S., Neubüser, C., Pinto, O., Provenza, A., Reinecke, M., Sefkow, F., Schuwalow, S., Sudo, Y., Tran, H.L., Buhmann, P., Garutti, E., Lomidze, D., Martens, S., Matysek, M., Bilki, B., Northacker, D., Onel, Y., Doren, B. van, Wilson, G.W., Kawagoe, K., Miura, Y., Mori, R., Sekiya, I., Suehara, T., Yoshioka, T., Belver, D., Alamillo, E. Calvo, Fouz, M.C., Cabrera, H. García, Marín, J., Navarrete, J., Pelayo, J. Puerta, Verdugo, A., Corriveau, F., Freund, B., Chadeeva, M., Danilov, M., Gabriel, M., Emberger, L., Graf, C., Israeli, Y., Simon, F., Szalay, M., Windel, H., Bilokin, S., Bonis, J., Irles, A., Pöschl, R., Thiebault, A., Richard, F., Zerwas, D., Cvach, J., Janata, M., Kovalcuk, M., Polak, I., Smolik, J., Vrba, V., Zalesak, J., Zuklin, J., Takeshita, T., Elkhalii, A., Götze, M., Zeitnitz, C., Chang, S., Khan, A., Kim, D.H., Kong, D.J., Oh, Y.D.

“…We present a study of the response of the highly granular Digital Hadronic Calorimeter with steel absorbers, the Fe-DHCAL, to positrons, muons, and pions with…”
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Vertical adaptation of the center of mass in human running on uneven ground by Ernst, M., Götze, M., Müller, R., Blickhan, R.

“…•We studied the vertical adaptation of the CoM in human running on uneven ground.•Runners actively adapt their CoM height in front of ground level…”
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