Search Results - "Goetz, Magdalena"

Self-organization of stem cells into embryos: A window on early mammalian development by Shahbazi, Marta N, Siggia, Eric D, Zernicka-Goetz, Magdalena

“…Embryonic development is orchestrated by robust and complex regulatory mechanisms acting at different scales of organization. In vivo studies are particularly…”
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Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism by Singla, Shruti, Iwamoto-Stohl, Lisa K., Zhu, Meng, Zernicka-Goetz, Magdalena

“…The high incidence of aneuploidy in the embryo is considered the principal cause for low human fecundity. However, the prevalence of aneuploidy dramatically…”
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Reconstructing aspects of human embryogenesis with pluripotent stem cells by Sozen, Berna, Jorgensen, Victoria, Weatherbee, Bailey A. T., Chen, Sisi, Zhu, Meng, Zernicka-Goetz, Magdalena

“…Understanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain…”
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PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications by Shi, Junchao, Zhang, Yunfang, Tan, Dongmei, Zhang, Xudong, Yan, Menghong, Zhang, Ying, Franklin, Reuben, Shahbazi, Marta, Mackinlay, Kirsty, Liu, Shichao, Kuhle, Bernhard, James, Emma R., Zhang, Liwen, Qu, Yongcun, Zhai, Qiwei, Zhao, Wenxin, Zhao, Linlin, Zhou, Changcheng, Gu, Weifeng, Murn, Jernej, Guo, Jingtao, Carrell, Douglas T., Wang, Yinsheng, Chen, Xuemei, Cairns, Bradley R., Yang, Xiang-lei, Schimmel, Paul, Zernicka-Goetz, Magdalena, Cheloufi, Sihem, Zhang, Ying, Zhou, Tong, Chen, Qi

“…Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-coding RNA (sncRNA) discovery, the currently widely used complementary DNA…”
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Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation by Bedzhov, Ivan, Zernicka-Goetz, Magdalena

“…Transformation of pluripotent epiblast cells into a cup-shaped epithelium as the mouse blastocyst implants is a poorly understood and yet key developmental…”
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The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo by Goolam, Mubeen, Zernicka-Goetz, Magdalena

“…The separation of embryonic from extra-embryonic tissues within the inner cell mass to generate the epiblast (EPI), which will form the new organism, from the…”
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Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids by Rawlings, Thomas M, Makwana, Komal, Taylor, Deborah M, Molè, Matteo A, Fishwick, Katherine J, Tryfonos, Maria, Odendaal, Joshua, Hawkes, Amelia, Zernicka-Goetz, Magdalena, Hartshorne, Geraldine M, Brosens, Jan J, Lucas, Emma S

“…Decidual remodelling of midluteal endometrium leads to a short implantation window after which the uterine mucosa either breaks down or is transformed into a…”
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E‐cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities by Liang, Xuan, Weberling, Antonia, Hii, Chun Yuan, Zernicka‐Goetz, Magdalena, Buckley, Clare E

“…Individual cells within de novo polarising tubes and cavities must integrate their forming apical domains into a centralised apical membrane initiation site…”
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Developmental potential of aneuploid human embryos cultured beyond implantation by Shahbazi, Marta N., Wang, Tianren, Tao, Xin, Weatherbee, Bailey A. T., Sun, Li, Zhan, Yiping, Keller, Laura, Smith, Gary D., Pellicer, Antonio, Scott, Richard T., Seli, Emre, Zernicka-Goetz, Magdalena

“…Aneuploidy, the presence of an abnormal number of chromosomes, is a major cause of early pregnancy loss in humans. Yet, the developmental consequences of…”
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A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre by Molè, Matteo A., Coorens, Tim H. H., Shahbazi, Marta N., Weberling, Antonia, Weatherbee, Bailey A. T., Gantner, Carlos W., Sancho-Serra, Carmen, Richardson, Lucy, Drinkwater, Abbie, Syed, Najma, Engley, Stephanie, Snell, Philip, Christie, Leila, Elder, Kay, Campbell, Alison, Fishel, Simon, Behjati, Sam, Vento-Tormo, Roser, Zernicka-Goetz, Magdalena

“…Following implantation, the human embryo undergoes major morphogenetic transformations that establish the future body plan. While the molecular events…”
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Deconstructing and reconstructing the mouse and human early embryo by Shahbazi, Marta N., Zernicka-Goetz, Magdalena

“…The emergence of form and function during mammalian embryogenesis is a complex process that involves multiple regulatory levels. The foundations of the body…”
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Human embryo polarization requires PLC signaling to mediate trophectoderm specification by Zhu, Meng, Shahbazi, Marta, Martin, Angel, Zhang, Chuanxin, Sozen, Berna, Borsos, Mate, Mandelbaum, Rachel S, Paulson, Richard J, Mole, Matteo A, Esbert, Marga, Titus, Shiny, Scott, Richard T, Campbell, Alison, Fishel, Simon, Gradinaru, Viviana, Zhao, Han, Wu, Keliang, Chen, Zi-Jiang, Seli, Emre, de Los Santos, Maria J, Zernicka Goetz, Magdalena

“…Apico-basal polarization of cells within the embryo is critical for the segregation of distinct lineages during mammalian development. Polarized cells become…”
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Stain-free detection of embryo polarization using deep learning by Shen, Cheng, Lamba, Adiyant, Zhu, Meng, Zhang, Ray, Zernicka-Goetz, Magdalena, Yang, Changhuei

“…Polarization of the mammalian embryo at the right developmental time is critical for its development to term and would be valuable in assessing the potential…”
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Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro by Harrison, Sarah Ellys, Sozen, Berna, Christodoulou, Neophytos, Kyprianou, Christos, Zernicka-Goetz, Magdalena

“…Mammalian embryogenesis requires intricate interactions between embryonic and extraembryonic tissues to orchestrate and coordinate morphogenesis with changes…”
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Cell death and morphogenesis during early mouse development: Are they interconnected? by Bedzhov, Ivan, Zernicka‐Goetz, Magdalena

“…Shortly after implantation the embryonic lineage transforms from a coherent ball of cells into polarized cup shaped epithelium. Recently we elucidated a…”
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Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo by Chen, Qi, Shi, Junchao, Tao, Yi, Zernicka-Goetz, Magdalena

“…A fundamental question in developmental and stem cell biology concerns the origin and nature of signals that initiate asymmetry leading to pattern formation…”
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Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism by Duethorn, Binyamin, Groll, Fabian, Rieger, Bettina, Drexler, Hannes C. A., Brinkmann, Heike, Kremer, Ludmila, Stehling, Martin, Borowski, Marie-Theres, Mildner, Karina, Zeuschner, Dagmar, Zernicka-Goetz, Magdalena, Stemmler, Marc P., Busch, Karin B., Vaquerizas, Juan M., Bedzhov, Ivan

“…Lima1 is an extensively studied prognostic marker of malignancy and is also considered to be a tumour suppressor, but its role in a developmental context of…”
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Trophectoderm mechanics direct epiblast shape upon embryo implantation by Weberling, Antonia, Zernicka-Goetz, Magdalena

“…Implantation is a hallmark of mammalian embryogenesis during which embryos establish their contacts with the maternal endometrium, remodel, and undertake…”
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An in vitro stem cell model of human epiblast and yolk sac interaction by Mackinlay, Kirsty Ml, Weatherbee, Bailey At, Souza Rosa, Viviane, Handford, Charlotte E, Hudson, George, Coorens, Tim, Pereira, Lygia V, Behjati, Sam, Vallier, Ludovic, Shahbazi, Marta N, Zernicka-Goetz, Magdalena

“…Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct…”
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Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms by Leung, Chuen Yan, Zernicka-Goetz, Magdalena

“…Cell identity is specified in the early mammalian embryo by the generation of precursors for two cell lineages: the pluripotent inner cell mass and…”
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