Search Results - "Goettsch, W"

Real World Data in Adaptive Biomedical Innovation: A Framework for Generating Evidence Fit for Decision-Making by Schneeweiss, S, Eichler, H-G, Garcia-Altes, A, Chinn, C, Eggimann, A-V, Garner, S, Goettsch, W, Lim, R, Löbker, W, Martin, D, Müller, T, Park, BJ, Platt, R, Priddy, S, Ruhl, M, Spooner, A, Vannieuwenhuyse, B, Willke, RJ

“…Analyses of healthcare databases (claims, electronic health records [EHRs]) are useful supplements to clinical trials for generating evidence on the…”
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Implementing managed entry agreements in practice: The Dutch reality check by Makady, A., van Veelen, A., de Boer, A., Hillege, H., Klungel, O.H., Goettsch, W.

“…•Conditional financing of drugs in the Netherlands: example of Managed Entry Agreements.•Despite the scheme’s promise, retrospective policy evaluation…”
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From adaptive licensing to adaptive pathways: Delivering a flexible life-span approach to bring new drugs to patients by Eichler, H-G, Baird, LG, Barker, R, Bloechl-Daum, B, Børlum-Kristensen, F, Brown, J, Chua, R, Del Signore, S, Dugan, U, Ferguson, J, Garner, S, Goettsch, W, Haigh, J, Honig, P, Hoos, A, Huckle, P, Kondo, T, Le Cam, Y, Leufkens, H, Lim, R, Longson, C, Lumpkin, M, Maraganore, J, O'Rourke, B, Oye, K, Pezalla, E, Pignatti, F, Raine, J, Rasi, G, Salmonson, T, Samaha, D, Schneeweiss, S, Siviero, PD, Skinner, M, Teagarden, JR, Tominaga, T, Trusheim, MR, Tunis, S, Unger, TF, Vamvakas, S, Hirsch, G

“…The concept of adaptive licensing (AL) has met with considerable interest. Yet some remain skeptical about its feasibility. Others argue that the focus and…”
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Relative effectiveness assessments of oncology medicines for pricing and reimbursement decisions in European countries by Kleijnen, S., Lipska, I., Leonardo Alves, T., Meijboom, K., Elsada, A., Vervölgyi, V., d'Andon, A., Timoney, A., Leufkens, H.G., De Boer, A., Goettsch, W.G.

“…There is a debate on the added clinical value of new, expensive, anticancer treatments. Among European decision makers, the relevance of commonly used end…”
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A European study on the relationship between antimicrobial use and antimicrobial resistance by Bronzwaer, Stef L A M, Cars, Otto, Buchholz, Udo, Mölstad, Sigvard, Goettsch, Wim, Veldhuijzen, Irene K, Kool, Jacob L, Sprenger, Marc J W, Degener, John E

“…In Europe, antimicrobial resistance has been monitored since 1998 by the European Antimicrobial Resistance Surveillance System (EARSS). We examined the…”
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Social Media: A Valuable Tool to Assess Patient Perspectives Regarding Quality of Life by Kalf, R, Makady, A, Ryll, B, Spurrier, G, Goettsch, W

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Long term persistence with statin treatment in daily medical practice by Mantel-Teeuwisse, A K, Goettsch, W G, Klungel, O H, de Boer, A, Herings, R M C

“…Crude RR 95% CI Adjusted* RR 95% CI Characteristics at index date Sex Male 1 1 Female 0.98 0.93 to 1.04 1.01 0.95 to 1.07 Age group (year) 0-44 1 1 45-64 0.83…”
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The First Experiences with Reassessments and Appraisals of Conditionally Approved Expensive and Orphan Drugs in the Netherlands (2006-2013) by van der Meijden, C.M.J, Streuper, C, Goettsch, W

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Practicalities Of Using Real-World Evidence (RWE) In Comparative Effectiveness Research (CER): Learnings From Imi-Getreal by Makady, A, Stegenga, H, Ciaglia, A, Debray, TP, Lees, M, Ryll, B, Abrams, KR, Thwaites, R, Garner, S, Jonsson, P, Goettsch, W

“…OBJECTIVES: The IMI-GetReal project aimed to explore incorporation of robust methods for real-world evidence (RWE) collection and synthesis in the medicines…”
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Burden of illness of bacterial cellulitis and erysipelas of the leg in the Netherlands by Goettsch, WG, Bouwes Bavinck, JN, Herings, RMC

“…Background  Information on the prevalence of bacterial cellulitis (BC) and erysipelas (ER) of the leg (BCERL) is sparse and dependent on the definitions used…”
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Applicability Of Eunethta Relative Effectiveness Assessment of Pazopanib For National Assessments by Kleijnen, S, Leufkens, H.G.M, Boer, A, Goettsch, W, Fathallah, M

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Increased gene expression of the cardiac endothelin system in obese mice by Catar, R A, Muller, G, Brandt, A, Langbein, H, Brunssen, C, Goettsch, C, Frenzel, A, Hofmann, A, Goettsch, W, Steinbronn, N, Strasser, R H, Schubert, U, Ludwig, B, Bornstein, S R, Morawietz, H

“…Obesity is a well-known risk factor of atherosclerosis and heart failure. In the human heart, a local endothelin system containing prepro-endothelin-1,…”
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Persistent bisphosphonate use and the risk of osteoporotic fractures in clinical practice: a database analysis study by van den Boogaard, C. H. A., Breekveldt‐Postma, N. S., Borggreve, S. E., Goettsch, W. G., Herings, R. M. C.

“…ABSTRACT Objective: This study aimed to investigate the association between persistent use of bisphosphonates and the risk of osteoporotic fractures in…”
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Increasing resistance to fluoroquinolones in Escherichia coli from urinary tract infections in The Netherlands by Goettsch, W., van Pelt, W., Nagelkerke, N., Hendrix, M. G. R., Buiting, A. G. M., Petit, P. L., Sabbe, L. J. M., van Griethuysen, A. J. A., de Neeling, A. J.

“…In continuous surveillance of routine samples from five Dutch laboratories, we studied resistance to the antibiotics most commonly prescribed for urinary tract…”
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Adherence to evidence-based statin guidelines reduces the risk of hospitalizations for acute myocardial infarction by 40%: a cohort study by Penning-van Beest, Fernie J.A., Termorshuizen, Fabian, Goettsch, Wim G., Klungel, Olaf H., Kastelein, John J.P., Herings, Ron M.C.

“…Aims To investigate the 'real world' effectiveness of robust statin therapy, focusing on the effect of dose and early treatment discontinuation on the risk of…”
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COUP-TFII is regulated by high glucose in endothelial cells by Brunssen, C, Korten, S, Brux, M, Seifert, S, Roesler, J, Bornstein, S R, Morawietz, H, Goettsch, W

“…Diabetes mellitus is an important risk factor for cardiovascular diseases. Clinical evidence supports a link between hyperglycemia, endothelial dysfunction,…”
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Expression of human endothelin-converting enzyme isoforms: role of angiotensin II by Goettsch, W, Schubert, A, Morawietz, H

“…A key step in endothelin-1 (ET-1) synthesis is the proteolytic cleavage of big ET-1 by the endothelin-converting enzyme-1 (ECE-1). Four alternatively spliced…”
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Resistance in Campylobacter Species: Increased Resistance to Fluoroquinolones and Seasonal Variation by Talsma, E., Goettsch, W. G., Nieste, H. L. J., Schrijnemakers, P. M., Sprenger, M. J. W.

“…To identify epidemiological features of culture-proven campylobacter infections and to determine resistance rates, we conducted a 4-year demographic survey of…”
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Antibiotic use and resistance of Streptococcus pneumoniae in The Netherlands during the period 1994–1999 by de Neeling, A. J., Overbeek, B. P., Horrevorts, A. M., Ligtvoet, E. E. J., Goettsch, W. G.

“…Antibiotic use in The Netherlands during the period 1994–1999 is described in relation to the resistance of routine isolates of Streptococcus pneumoniae. The…”
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Results from a rosuvastatin historical cohort study in more than 45 000 Dutch statin users, a PHARMO study by Goettsch, W.G., Heintjes, E.M., Kastelein, J.J.P., Rabelink, T.J., Johansson, Saga, Herings, R.M.C.

“…Purpose Clinical benefits of statin therapy are accepted, but their safety profiles have been under scrutiny, particularly for the recently introduced statin,…”
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