Search Results - "Goettl, V M"

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies by Hing, Z A, Fung, H Y J, Ranganathan, P, Mitchell, S, El-Gamal, D, Woyach, J A, Williams, K, Goettl, V M, Smith, J, Yu, X, Meng, X, Sun, Q, Cagatay, T, Lehman, A M, Lucas, D M, Baloglu, E, Shacham, S, Kauffman, M G, Byrd, J C, Chook, Y M, Garzon, R, Lapalombella, R

“…The nuclear export receptor, Exportin 1 (XPO1), mediates transport of growth-regulatory proteins, including tumor suppressors, and is overactive in many…”
Get full text

Selinexor suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells by Zhong, Y, El-Gamal, D, Dubovsky, J A, Beckwith, K A, Harrington, B K, Williams, K E, Goettl, V M, Jha, S, Mo, X, Jones, J A, Flynn, J M, Maddocks, K J, Andritsos, L A, McCauley, D, Shacham, S, Kauffman, M, Byrd, J C, Lapalombella, R

Get full text

Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice by Hacimuftuoglu, A., Handy, C.R., Goettl, V.M., Lin, C.G., Dane, S., Stephens, R.L.

“…An emerging theme in the study of the pathophysiology of chronic and persistent pain is the role of pro-oxidant substances. Reactive oxygen species (ROS) have…”
Get full text

GM1 enhances dopaminergic markers in the brain of aged rats by Goettl, V.M, Zhang, H, Burrows, A.C, Wemlinger, T.A, Neff, N.H, Hadjiconstantinou, M

“…A number of presynaptic markers are compromised in the dopaminergic neurons of aged Sprague–Dawley rats (22 months old) compared with young rats (3 months…”
Get full text

GM1 ganglioside restores dopaminergic neurochemical and morphological markers in aged rats by Goettl, V.M., Wemlinger, T.A., Duchemin, A.-M., Neff, N.H., Hadjiconstantinou, M.

“…The monosialoganglioside GM1 exerts neurotrophic-like activity in vitro and in vivo. In particular, it improves cholinergic neuron morphology and chemistry and…”
Get full text

Decreased neuropeptide content in the spinal cord of aged rats: the effect of GM1 ganglioside by Goettl, Virginia M, Tejwani, Gopi A, Neff, Norton H, Hadjiconstantinou, Maria

“…THIS study investigated the status of substance P (SP), methionine-enkephalin (Met-Enk) and dynorphin A(1-13) (Dyn A) in the spinal cord of aged Sprague–Dawley…”
Get full text

Inhibition of substance P release from spinal cord tissue after pretreatment with capsaicin does not mediate the antinociceptive effect of capsaicin in adult mice by Goettl, V M, Larson, D L, Portoghese, P S, Larson, A A

“…Substance P (SP) is released from primary afferent fibers in response to nociceptive stimuli. Capsaicin, which produces an initial hyperalgesic response…”
Get more information

GM1 ganglioside restores abnormal responses to acute thermal and mechanical stimuli in aged rats by Goettl, Virginia M., Lindsey, Amy E., Neff, Norton H., Hadjiconstantinou, Maria

“…We investigated the effect of aging on the responses to thermal and mechanical stimuli in rats. Young (3–5 months old) and aged (22–24 months old) male…”
Get full text

Activity at phencyclidine and mu opioid sites mediates the hyperalgesic and antinociceptive properties of the N-terminus of substance P in a model of visceral pain by Goettl, V M, Larson, A A

“…Substance P, a putative neurotransmitter or neuromodulator of nociception or pain in the spinal cord, exhibits both antinociceptive and hyperalgesic…”
Get more information

Glutamate uptake is attenuated in spinal deep dorsal and ventral horn in the rat spinal nerve ligation model by Binns, Brian C., Huang, Y., Goettl, Virginia M., Hackshaw, Kevin V., Stephens, Robert L.

“…Alteration of glutamatergic (GLU) neurotransmission within the spinal cord contributes to hyperalgesic and allodynic responses following nerve injury. In…”
Get full text

Boron neutron capture therapy of brain tumors : functional and neuropathologic effects of blood-brain barrier disruption and intracarotid injection of sodium borocaptate and boronophenylalanine by WEILIAN YANG, BARTH, Rolf F, ROTARU, Joan H, BOESEL, Carl P, WILKIE, David A, BRESNAHAN, Jacqueline C, HADJICONSTANTINOU, Marie, GOETTL, Virginia M, JOEL, Darrel D, NAWROCKY, Marta M

“…Sodium borocaptate (BSH) and boronophenylalanine (BPA) are two drugs that have been used clinically for boron neutron capture therapy (BNCT) of brain tumors…”
Get full text

Nitric oxide mediates long-term hyperalgesic and antinociceptive effects of the N-terminus of substance P in the formalin assay in mice by Goettl, V M, Larson, A A

“…Conditions such as hyperalgesia can occur days or months after the noxious insult. Substance P (SP) is released in response to noxious stimuli. Given the…”
Get more information

Antinociception induced by 3-((+-)-2-carboxypiperazin-4-yl)-propyl-1- phosphonic acid (CPP), an N-methyl-D-aspartate (NMDA) competitive antagonist, plus 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist, differs from that induced by MK-801 plus DNQX by Goettl, V M, Larson, A A

“…Excitatory amino acid receptors have been implicated in mediating pain. 3-((+-)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a competitive…”
Get more information

Substance P N-terminus inhibits C-fiber-dependent facilitation of the rat flexor reflex by Goettl, V M, Xu, X J, Larson, A A, Wiesenfeld-Hallin, Z

“…Substance P injected intrathecally or a conditioning stimulus (1 Hz, 20 s) at C-fiber strength, which releases substance P from intraspinal primary afferent…”
Get more information

Effects of calcium antagonists on mechanical responses of mammalian skeletal muscles by Gallant, E M, Goettl, V M

“…Rodent muscles were exposed to several organic calcium antagonists, and mechanical responses to direct electrical stimulation were recorded. Verapamil and…”
Get more information

Porcine malignant hyperthermia: halothane effects on force generation in skeletal muscles by Gallant, E M, Goettl, V M

“…Halothane-induced malignant hyperthermia (MH) is thought to result from a defect in the regulation of cytosolic calcium concentration in MH-susceptible (MHS)…”
Get more information

Porcine malignant hyperthermia: cell injury enhances halothane sensitivity of biopsies by Gallant, E M, Fletcher, T F, Goettl, V M, Rempel, W E

“…A possible relationship between muscle cell injury or deterioration and enhanced halothane sensitivity was studied by monitoring mechanical responses of…”
Get more information

Motoric behavior in aged rats treated with GM1 by Goettl, Virginia M, Wemlinger, Trina A, Colvin, Amy E, Neff, Norton H, Hadjiconstantinou, Maria

“…Aging is associated with impaired motor function. Nigrostriatal dopaminergic neurons, in part, regulate motoric behavior, and undergo degenerative changes…”
Get full text

An antagonist of substance P N-terminal fragments, d-substance P(1–7), reveals that both nociceptive and antinociceptive effects are induced by substance P N-terminal activity during noxious chemical stimulation by Goettl, Virginia M, Larson, Alice A

“…Substance P (SP) N-terminal fragments are known to alter nociception when injected intrathecally or when released in response to capsaicin. However, it is not…”
Get full text

Retinal cholinergic and dopaminergic deficits of aged rats are improved following treatment with GM1 ganglioside by Goettl, Virginia M., Wemlinger, Trina A., Fong, Tamara G., Neff, Norton H., Hadjiconstantinou, Maria

“…Selected cholinergic and dopaminergic markers were compared in the retina of aged (20–22-months-old) and young (3-months-old) rats before and after treatment…”
Get full text