Effects of Melatonin on Plasma S-Nitrosoglutathione and Glutathione in Streptozotocin-Treated Rats

Effects of Melatonin on Plasma S-Nitrosoglutathione and Glutathione in Streptozotocin-Treated Rats

The aim of this study was to determine the effects of streptozotocin-induced diabetes on plasma reduced glutathione (GSH) and S-nitrosoglutathione (GSNO) levels. Further, the study investigated whether an antioxidant, pineal hormone melatonin, could protect against STZ-induced effects. STZ significa...

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Bibliographic Details
Published in:Journal of Toxicology and Environmental Health, Part A Vol. 67; no. 13; pp. 979 - 986
Main Authors: Goerguen, F M, Koekoglu, E, Guemuestas, M K, Altug, T, Cansever, S, Kavunoglu, G
Format: Journal Article
Language:English
Published: England Taylor & Francis Group 09-07-2004
Subjects:
Animals
Antioxidants - administration & dosage
Antioxidants - pharmacology
Antioxidants - therapeutic use
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - drug therapy
Dietary Supplements
Glutathione - blood
Male
Melatonin - administration & dosage
Melatonin - pharmacology
Melatonin - therapeutic use
Rats
Rats, Wistar
S-Nitrosoglutathione - blood
Streptozocin
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Summary:The aim of this study was to determine the effects of streptozotocin-induced diabetes on plasma reduced glutathione (GSH) and S-nitrosoglutathione (GSNO) levels. Further, the study investigated whether an antioxidant, pineal hormone melatonin, could protect against STZ-induced effects. STZ significantly decreased plasma GSH but increased the levels of plasma GSNO. Daily supplementation with melatonin restored plasma thiol to control values. Data suggest that STZ-induced hyperglycemia and compounds that act as scavengers of free radicals and peroxynitrite like melatonin may exert protection against STZ-induced toxicity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1528-7394
1087-2620
DOI:10.1080/15287390490447278