Search Results - "Goepferich, Achim"

Ligand Density and Linker Length are Critical Factors for Multivalent Nanoparticle–Receptor Interactions by Abstiens, Kathrin, Gregoritza, Manuel, Goepferich, Achim M

“…Although there are a large number of studies available for the evaluation of the therapeutic efficacy of targeted polymeric nanoparticles, little is known…”
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Hydrogels in ophthalmic applications by Kirchhof, Susanne, Goepferich, Achim M., Brandl, Ferdinand P.

“…[Display omitted] More and more people worldwide are affected by severe eye diseases eventually leading to visual impairment or blindness. In most cases, the…”
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Intracellular availability of poorly soluble drugs from lipid nanocapsules by Bohley, Marilena, Haunberger, Alexandra, Goepferich, Achim M.

“…[Display omitted] Lipid nanocapsules (LNCs) are extensively used as drug carrier systems, due to their small size distribution, biocompatibility and ease of…”
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Interaction of functionalized nanoparticles with serum proteins and its impact on colloidal stability and cargo leaching by Abstiens, Kathrin, Maslanka Figueroa, Sara, Gregoritza, Manuel, Goepferich, Achim M

“…The majority of effort in the area of polymeric nanocarriers is aimed at providing controlled drug delivery in vivo. Therefore, it is essential to understand…”
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Breaking up the Correlation between Efficacy and Toxicity for Nonviral Gene Delivery by Breunig, Miriam, Lungwitz, Uta, Liebl, Renate, Goepferich, Achim

“…Nonviral nucleic acid delivery to cells and tissues is considered a standard tool in life science research. However, although an ideal delivery system should…”
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In Situ Forming iEDDA Hydrogels with Tunable Gelation Time Release High-Molecular Weight Proteins in a Controlled Manner over an Extended Time by Ziegler, Christian E, Graf, Moritz, Nagaoka, Makoto, Lehr, Heike, Goepferich, Achim M

“…Off-target interactions between reactive hydrogel moieties and drug cargo as well as slow reaction kinetics and the absence of controlled protein release over…”
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Laser-induced graphene interdigitated electrodes for label-free or nanolabel-enhanced highly sensitive capacitive aptamer-based biosensors by Yagati, Ajay Kumar, Behrent, Arne, Beck, Sebastian, Rink, Simone, Goepferich, Achim M., Min, Junhong, Lee, Min-Ho, Baeumner, Antje J.

“…Highly porous laser-induced graphene (LIG) is easily generated in complex electrode configurations such as interdigitated electrodes (IDEs). Here, we…”
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Thermodynamic, Spatial and Methodological Considerations for the Manufacturing of Therapeutic Polymer Nanoparticles by Maslanka Figueroa, Sara, Fleischmann, Daniel, Beck, Sebastian, Goepferich, Achim

“…Purpose Evaluate fundamental parameters that dictate the effectiveness of drug loading. Methods A model water-soluble drug lacking ionizable groups,…”
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Hydrogel wound dressings for bioactive treatment of acute and chronic wounds by Koehler, Julia, Brandl, Ferdinand P., Goepferich, Achim M.

“…[Display omitted] Hydrogel-based wound dressings are one of the most promising materials in wound care, fulfilling important dressing requirements, including:…”
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Investigation of the Impact of Hydrolytically Cleavable Groups on the Stability of Poly(ethylene glycol) Based Hydrogels Cross‐Linked via the Inverse Electron Demand Diels–Alder (iEDDA) Reaction by Ziegler, Christian E., Graf, Moritz, Nagaoka, Makoto, Goepferich, Achim M.

“…Eight‐armed poly(ethylene glycol) (PEG) hydrogels cross‐linked via inverse electron demand Diels–Alder reaction between norbornene and tetrazine groups are…”
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Enzyme-triggered antigen release enhances cross-presentation by dendritic cells by Stahl, Monika, Holzinger, Jonas, Bülow, Sigrid, Goepferich, Achim M.

“…Nanoparticles hold great potential as vaccine carriers due to their highly versatile structure and the possibility to influence intracellular trafficking and…”
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Hydrogel microspheres evading alveolar macrophages for sustained pulmonary protein delivery by Graf, Moritz, Ziegler, Christian E., Gregoritza, Manuel, Goepferich, Achim M.

“…[Display omitted] Pulmonary delivery is a highly attractive alternative to injections for biologics such as therapeutic proteins. However, bioavailabilities…”
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A novel anhydrous preparation of PEG hydrogels enables high drug loading with biologics for controlled release applications by Ziegler, Christian E., Graf, Moritz, Beck, Sebastian, Goepferich, Achim M.

“…[Display omitted] •Diels-Alder polymers represent an anhydrous preparation method for PEG hydrogels.•Water absence prevents hydrolysis of maleimide…”
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Fabrication of antibody-loaded microgels using microfluidics and thiol-ene photoclick chemistry by Gregoritza, Manuel, Abstiens, Kathrin, Graf, Moritz, Goepferich, Achim M.

“…[Display omitted] Reducing burst effects, providing controlled release, and safeguarding biologics against degradation are a few of several highly attractive…”
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pH‐Modulating Poly(ethylene glycol)/Alginate Hydrogel Dressings for the Treatment of Chronic Wounds by Koehler, Julia, Wallmeyer, Leonie, Hedtrich, Sarah, Goepferich, Achim M., Brandl, Ferdinand P.

“…The development of chronic wounds has been frequently associated with alkaline pH values. The application of pH‐modulating wound dressings can, therefore, be a…”
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Matrices and scaffolds for protein delivery in tissue engineering by Tessmar, Joerg K., Göpferich, Achim M.

“…The tissue engineering of functional tissues depends on the development of suitable scaffolds to support three dimensional cell growth. To improve the…”
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Injectable Anhydrous Poly(ethylene glycol) Polymer Liquids Form Protein Depot for Extended Controlled Release Applications Via Rapid In Situ Gelation by Ziegler, Christian E., Graf, Moritz, Nagaoka, Makoto, Groner, Jonas, Mietzner, Raphael, Breunig, Miriam, Goepferich, Achim M.

“…Water-free preparation of protein delivery systems has the potential to overcome the limitations of hydrogel depot systems such as off-target reactions,…”
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HPLC analysis as a tool for assessing targeted liposome composition by Oswald, Mira, Platscher, Michael, Geissler, Simon, Goepferich, Achim

“…[Display omitted] Functionalized phospholipids are indispensable materials for the design of targeted liposomes. Control over the quality and quantity of…”
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Influenza A virus mimetic nanoparticles trigger selective cell uptake by Figueroa, Sara Maslanka, Veser, Anika, Abstiens, Kathrin, Fleischmann, Daniel, Beck, Sebastian, Goepferich, Achim

“…Poor target cell specificity is currently a major shortcoming of nanoparticles (NPs) used for biomedical applications. It causes significant material loss to…”
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Targeted Delivery of Soluble Guanylate Cyclase (sGC) Activator Cinaciguat to Renal Mesangial Cells via Virus-Mimetic Nanoparticles Potentiates Anti-Fibrotic Effects by cGMP-Mediated Suppression of the TGF-β Pathway by Fleischmann, Daniel, Harloff, Manuela, Maslanka Figueroa, Sara, Schlossmann, Jens, Goepferich, Achim

“…Diabetic nephropathy (DN) ranks among the most detrimental long-term effects of diabetes, affecting more than 30% of all patients. Within the diseased kidney,…”
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