Search Results - "Goeman, F."

KEAP1-driven co-mutations in lung adenocarcinoma unresponsive to immunotherapy despite high tumor mutational burden by Marinelli, D., Mazzotta, M., Scalera, S., Terrenato, I., Sperati, F., D'Ambrosio, L., Pallocca, M., Corleone, G., Krasniqi, E., Pizzuti, L., Barba, M., Carpano, S., Vici, P., Filetti, M., Giusti, R., Vecchione, A., Occhipinti, M., Gelibter, A., Botticelli, A., De Nicola, F., Ciuffreda, L., Goeman, F., Gallo, E., Visca, P., Pescarmona, E., Fanciulli, M., De Maria, R., Marchetti, P., Ciliberto, G., Maugeri-Saccà, M.

“…Immune checkpoint inhibitors (ICIs) have demonstrated significant overall survival (OS) benefit in lung adenocarcinoma (LUAD). Nevertheless, a remarkable…”
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Clonal KEAP1 mutations with loss of heterozygosity share reduced immunotherapy efficacy and low immune cell infiltration in lung adenocarcinoma by Scalera, S., Ricciuti, B., Mazzotta, M., Calonaci, N., Alessi, J.V., Cipriani, L., Bon, G., Messina, B., Lamberti, G., Di Federico, A., Pecci, F., Milite, S., Krasniqi, E., Barba, M., Vici, P., Vecchione, A., De Nicola, F., Ciuffreda, L., Goeman, F., Fanciulli, M., Buglioni, S., Pescarmona, E., Sharma, B., Felt, K.D., Lindsay, J., Rodig, S.J., De Maria, R., Caravagna, G., Cappuzzo, F., Ciliberto, G., Awad, M.M., Maugeri-Saccà, M.

“…KEAP1 mutations have been associated with reduced survival in lung adenocarcinoma (LUAD) patients treated with immune checkpoint inhibitors (ICIs),…”
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Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53 by Desantis, A, Bruno, T, Catena, V, De Nicola, F, Goeman, F, Iezzi, S, Sorino, C, Gentileschi, M P, Germoni, S, Monteleone, V, Pellegrino, M, Kann, M, De Meo, P D, Pallocca, M, Höpker, K, Moretti, F, Mattei, E, Reinhardt, H C, Floridi, A, Passananti, C, Benzing, T, Blandino, G, Fanciulli, M

“…The tumor suppressor p53 is mainly involved in the transcriptional regulation of a large number of growth-arrest- and apoptosis-related genes. However, a clear…”
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PO-496 Integrated OMICS- based approach to the identification of specific expression profiles associated with PTEN-loss by Ciuffreda, L, Bazzichetto, C, Conciatori, F, Sacconi, A, Pallocca, M, Donzelli, S, Goeman, F, Nicola, F De, Falcone, I, Milella, M

“…IntroductionPTEN is a protein that restrains cells from growing unchecked; when it is absent or not functioning (as it often happens in prostate and colorectal…”
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ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters by Dell'Orso, Stefania, Fontemaggi, Giulia, Stambolsky, Perry, Goeman, Frauke, Voellenkle, Christine, Levrero, Massimo, Strano, Sabrina, Rotter, Varda, Oren, Moshe, Blandino, Giovanni

“…Growing evidence shows that mutant p53 proteins, which are present in many human tumors, gain oncogenic activities that can actively contribute to…”
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Growth Inhibition by the Tumor Suppressor p33ING1 in Immortalized and Primary Cells: Involvement of Two Silencing Domains and Effect of Ras by Goeman, Frauke, Thormeyer, Dorit, Abad, Maria, Serrano, Manuel, Schmidt, Oliver, Palmero, Ignacio, Baniahmad, Aria

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Transcriptional repression by the insulator protein CTCF involves histone deacetylases by Lutz, M, Burke, L J, Barreto, G, Goeman, F, Greb, H, Arnold, R, Schultheiss, H, Brehm, A, Kouzarides, T, Lobanenkov, V, Renkawitz, R

“…The highly conserved zinc-finger protein, CTCF, is a candidate tumor suppressor protein that binds to highly divergent DNA sequences. CTCF has been connected…”
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