Search Results - "Goellner, G M"

Different mechanisms underlie DNA instability in Huntington disease and colorectal cancer by GOELLNER, G. M, TESTER, D, THIBODEAU, S, ALMQVIST, E, GOLDBERG, Y. P, HAYDEN, M. R, MCMURRAY, C. T

“…Two recent lines of evidence raise the possibility that instability in germ-line or somatic cells arises by a common mechanism that involves defective mismatch…”
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Recombination-induced CAG trinucleotide repeat expansions in yeast involve the MRE11-RAD50-XRS2 complex by Richard, G.F, Goellner, G.M, McMurray, C.T, Haber, J.E

“…Recombination induced by double‐strand breaks (DSBs) in yeast leads to a higher proportion of expansions to contractions than does replication‐associated tract…”
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GAA Instability in Friedreich's Ataxia Shares a Common, DNA-Directed and Intraallelic Mechanism with Other Trinucleotide Diseases by Gacy, A.Marquis, Goellner, Geoffrey M, Spiro, Craig, Chen, Xian, Gupta, Goutam, Bradbury, E.Morton, Dyer, Roy B, Mikesell, Marci J, Yao, Janet Z, Johnson, Aaron J, Richter, Andrea, Melançon, Serge B, McMurray, Cynthia T

“…We show that GAA instability in Friedreich's Ataxia is a DNA-directed mutation caused by improper DNA structure at the repeat region. Unlike CAG or CGG…”
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Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGγ as a therapeutic target by Bett, John S., Goellner, Geoffrey M., Woodman, Ben, Pratt, Gregory, Rechsteiner, Martin, Bates, Gillian P.

“…Huntington's disease (HD) is one of a group of neurodegenerative disorders caused by the pathological expansion of a glutamine tract. A hallmark of these…”
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Differentiation induces up-regulation of plasma membrane Ca(2+)-ATPase and concomitant increase in Ca(2+) efflux in human neuroblastoma cell line IMR-32 by Usachev, Y M, Toutenhoofd, S L, Goellner, G M, Strehler, E E, Thayer, S A

“…Precise regulation of intracellular Ca(2+) concentration ([Ca(2+)](i)) is achieved by the coordinated function of Ca(2+) channels and Ca(2+) buffers. Neuronal…”
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Characterization of Mammalian Ecm29, a 26 S Proteasome-associated Protein That Localizes to the Nucleus and Membrane Vesicles by Gorbea, Carlos, Goellner, Geoffrey M., Teter, Ken, Holmes, Randall K., Rechsteiner, Martin

“…In addition to its thirty or so core subunits, a number of accessory proteins associate with the 26 S proteasome presumably to assist in substrate degradation…”
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Differentiation induces up-regulation of plasma membrane Ca super(2+)-ATPase and concomitant increase in Ca super(2+) efflux in human neuroblastoma cell line IMR-32 by Usachev, Y M, Toutenhoofd, S L, Goellner, G M, Strehler, EE, Thayer, SA

“…Precise regulation of intracellular Ca super(2+) concentration ([Ca super(2+)] sub(i)) is achieved by the coordinated function of Ca super(2+) channels and Ca…”
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Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGγ as a therapeutic target by Bett, John S., Goellner, Geoffrey M., Woodman, Ben, Pratt, Gregory, Rechsteiner, Martin, Bates, Gillian P.

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Differentiation induces up‐regulation of plasma membrane Ca2+‐ATPase and concomitant increase in Ca2+ efflux in human neuroblastoma cell line IMR‐32 by Usachev, Yuriy M., Toutenhoofd, Sonja L., Goellner, Geoffrey M., Strehler, Emanuel E., Thayer, Stanley A.

“…Precise regulation of intracellular Ca2+ concentration ([Ca2+]i) is achieved by the coordinated function of Ca2+ channels and Ca2+ buffers. Neuronal…”
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