Search Results - "Goehle, Sondra"

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes by HELTWEG, Birgit, GATBONTON, Tonibelle, BEDALOV, Antonio, SCHULER, Aaron D, POSAKONY, Jeff, HONGZHE LI, GOEHLE, Sondra, KOLLIPARA, Ramya, DEPINHO, Ronald A, YANSONG GU, SIMON, Julian A

“…SIRT1 and other NAD-dependent deacetylases have been implicated in control of cellular responses to stress and in tumorigenesis through deacetylation of…”
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Chemotypic variation of essential oils in the medicinal plant, Anemopsis californica by Medina-Holguín, Andrea L., Omar Holguín, F., Micheletto, Sandra, Goehle, Sondra, Simon, Julian A., O’Connell, Mary A.

“…Three chemotypes for the medicinal plant Anemopsis californica were detected using a clustering analysis on the abundance of 10 essential oil components in…”
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Thymidine incorporation is highly predictive of colony formation and can be used for high-throughput screening by Lamb, J R, Goehle, S, Ludlow, C, Simon, J A

“…The primary goal of anticancer chemotherapy is to kill cancer cells. Therefore, it is of critical importance that any assay that is used to determine the…”
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Identification of small molecules inducing apoptosis by cell-based assay using fission yeast deletion mutants by Chung, Kyung-Sook, Yim, Nam-Hui, Lee, Seung-Hee, Choi, Shin-Jung, Hur, Kyung-Sun, Hoe, Kwang-Lae, Kim, Dong-Uk, Goehle, Sondra, Kim, Hyung-Bae, Song, Kyung-Bin, Yoo, Hyang-Sook, Bae, Ki-Hwan, Simon, Julian, Won, Misun

“…Summary The cell-based assay using yeast deletion mutants has been recognized as an efficient analysis to discover therapeutic compounds and reveal their mode…”
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Cell-Based Assays for Identification of Novel Double-Strand Break-Inducing Agents by Dunstan, Heather M., Ludlow, Catherine, Goehle, Sondra, Cronk, Michelle, Szankasi, Philippe, Evans, David R. H., Simon, Julian A., Lamb, John R.

“…Background:We are developing cell-based assays to identify anticancer agents that are selectively toxic to cells with defined mutations. As a test, we used a…”
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Increased gene transfer into human hematopoietic progenitor cells by extended in vitro exposure to a pseudotyped retroviral vector by von Kalle, C, Kiem, HP, Goehle, S, Darovsky, B, Heimfeld, S, Torok-Storb, B, Storb, R, Schuening, FG

“…Retroviral-mediated gene transfer is the most attractive modality for gene transfer into hematopoietic stem cells. However, transduction efficiency has been…”
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Increased Gene Transfer Into Human Hematopoietic Progenitor Cells by Extended In Vitro Exposure to a Pseudotyped Retroviral Vector by Kalle, Christof von, Kiem, Hans-Peter, Goehle, Sondra, Darovsky, Boris, Heimfeld, Shelly, Torok-Storb, Beverly, Storb, Rainer, Schuening, Friedrich G.

“…Retroviral-mediated gene transfer is the most attractive modality for gene transfer into hematopoietic stem cells. However, transduction efficiency has been…”
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Retrovirus-mediated gene transduction into canine peripheral blood repopulating cells by KIEM, H.-P, DAROVSKY, B, STORB, R, SCHUENING, F. G, VON KALLE, C, GOEHLE, S, STEWART, D, GRAHAM, T, HACKMAN, R, APPELBAUM, F. R, DEEG, H. J, MILLER, A. D

“…Genetically marked peripheral blood progenitor cells were used to investigate their contribution to long-term hematopoietic reconstitution after autologous…”
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Retrovirus-mediated gene transduction into long-term repopulating marrow cells of dogs by SCHUENING, F. G, KAWAHARA, K, HACKMAN, R, OSBORNE, W. R. A, STORB, R, DUSTY MILLER, A, TO, R, GOEHLE, S, STEWART, D, MULLALLY, K, FISHER, L, GRAHAM, T. C, APPELBAUM, F. R

“…Amphotropic helper-free retrovirus vectors containing the bacterial neomycin phosphotransferase gene (neo) and the human adenosine deaminase gene (adenosine…”
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Myelosuppressive Conditioning Improves Autologous Engraftment of Genetically Marked Hematopoietic Repopulating Cells in Dogs by Barquinero, Jorge, Kiem, Hans-Peter, Kalle, Christof von, Darovsky, Boris, Goehle, Sondra, Graham, Ted, Seidel, Kristy, Storb, Rainer, Schuening, Friedrich G.

“…We have studied the role of different conditioning regimens for engraftment of genetically marked hematopoietic repopulating cells in dogs. Peripheral blood…”
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Long-term persistence of canine hematopoietic cells genetically marked by retrovirus vectors by Kiem, H P, Darovsky, B, Von Kalle, C, Goehle, S, Graham, T, Miller, A D, Storb, R, Schuening, F G

“…In 1991 we reported gene transduction into autologous long-term repopulating marrow cells in dogs using amphotropic helper-free retrovirus vectors containing…”
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Effect of Recombinant Human Granulocyte Colony-Stimulating Factor on Hematopoiesis of Normal Dogs and on Hematopoietic Recovery After Otherwise Lethal Total Body Irradiation by Schuening, Friedrich G., Storb, Rainer, Goehle, Sondra, Graham, Theodore C., Appelbaum, Frederick R., Hackman, Robert, Souza, Lawrence M.

“…This study was designed to test whether recombinant human G-CSF (rh G-CSF) affects hematopoiesis in normal dogs and, if so, to test the effects of G-CSF in…”
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Improved Retroviral Transfer of Genes Into Canine Hematopoietic Progenitor Cells Kept in Long-Term Marrow Culture by Schuening, Friedrich G., Storb, Rainer, Stead, Richard B., Goehle, Sondra, Nash, Richard, Miller, A. Dusty

“…Amphotropic helper-free retroviral vectors containing either the bacterial neomycin phosphotransferase gene (NEO) or a mutant dihydrofolate reductase gene…”
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T-Cell Subpopulations Identified by Monoclonal Antibodies After Human Marrow Transplantation. I. Helper-Inducer and Cytotoxic-Suppressor Subsets by Atkinson, Kerry, Hansen, John A., Storb, Rainer, Goehle, Sondra, Goldstein, Gideon, Thomas, E.Donnall

“…Peripheral blood helper–inducer and cytotoxic–suppressor T-cell subpopulations in patients receiving marrow transplants for the treatment of acute leukemia or…”
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Biochemical characterization of a unique canine myeloid antigen by Sandmaier, B M, Schuening, F G, Bianco, J A, Rosenman, S J, Bernstein, I, Goehle, S, Storb, R, Appelbaum, F R

“…In marrow transplantation, radioisotope-labeled monoclonal antibodies may provide a way to selectively deliver high doses of radiation to target tissues…”
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Recombinant Human Granulocyte Colony-Stimulating Factor Accelerates Hematopoietic Recovery After DLA-Identical Littermate Marrow Transplants in Dogs by Schuening, Friedrich G., Storb, Rainer, Goehle, Sondra, Graham, Theodore C., Hackman, Robert, Mori, Motomi, Souza, Lawrence M., Appelbaum, Frederick R.

“…We studied whether treatment of dogs with recombinant human granulocyte colony-stimulating factor (rhG-CSF), after 920 cGy total body irradiation (TBI) and…”
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Regulation of immunoglobulin production after human marrow grafting. The role of helper and suppressor T cells in acute graft-versus-host disease by Witherspoon, R P, Goehle, S, Kretschmer, M, Storb, R

“…The effect of acute graft-versus host disease (GVHD) on T4 and T8 lymphocyte regulation of in vitro immunoglobulin production was explored. The peripheral…”
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Canine Pluripotent Hematopoietic Stem Cells and CFU-GM Express la-like Antigens as Recognized by Two Different Class II-Specific Monoclonal Antibodies by Schuening, Friedrich, Storb, Rainer, Goehle, Sondra, Meyer, Joey, Graham, Theodore, Deeg, H.Joachim, Pesando, John

“…A previous study showed failure of autologous engraftment in lethally irradiated dogs when marrow was treated before infusion with anti-class II antibody 7.2…”
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Facilitation of engraftment of DLA-nonidentical marrow by treatment of recipients with monoclonal antibody directed against marrow cells surviving radiation by Schuening, F, Storb, R, Goehle, S, Meyer, J, Graham, T C, Deeg, H J, Appelbaum, F R, Sale, G E, Graf, L, Loughran, Jr, T P

“…Past studies in dogs have suggested that marrow graft rejection was mediated by major histocompatibility complex (MHC) class II antigen-positive non-T cells…”
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Enrichment (and depletion) of human suppressor cells with monoclonal antibodies and immunoglobulin-coated plates by Tsoi, M S, Aprile, J, Dobbs, S, Goehle, S, Storb, R

“…A cell separation method using immunoglobulin (Ig)-coated plates, originally devised for murine spleen cells, was modified and adapted for enrichment (and…”
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