Search Results - "Goehle, S"

Cell-Based Assays for Identification of Novel Double-Strand Break-Inducing Agents by Dunstan, Heather M., Ludlow, Catherine, Goehle, Sondra, Cronk, Michelle, Szankasi, Philippe, Evans, David R. H., Simon, Julian A., Lamb, John R.

“…Background:We are developing cell-based assays to identify anticancer agents that are selectively toxic to cells with defined mutations. As a test, we used a…”
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Effect of Recombinant Human Granulocyte Colony-Stimulating Factor on Hematopoiesis of Normal Dogs and on Hematopoietic Recovery After Otherwise Lethal Total Body Irradiation by Schuening, Friedrich G., Storb, Rainer, Goehle, Sondra, Graham, Theodore C., Appelbaum, Frederick R., Hackman, Robert, Souza, Lawrence M.

“…This study was designed to test whether recombinant human G-CSF (rh G-CSF) affects hematopoiesis in normal dogs and, if so, to test the effects of G-CSF in…”
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Humoral immune response limits gene therapy in canine MPS I [letter] by Shull, R, Lu, X, Dube, I, Lutzko, C, Kruth, S, Abrams-Ogg, A, Kiem, HP, Goehle, S, Schuening, F, Millan, C, Carter, R

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Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes by HELTWEG, Birgit, GATBONTON, Tonibelle, BEDALOV, Antonio, SCHULER, Aaron D, POSAKONY, Jeff, HONGZHE LI, GOEHLE, Sondra, KOLLIPARA, Ramya, DEPINHO, Ronald A, YANSONG GU, SIMON, Julian A

“…SIRT1 and other NAD-dependent deacetylases have been implicated in control of cellular responses to stress and in tumorigenesis through deacetylation of…”
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Improved retroviral transfer of genes into canine hematopoietic progenitor cells kept in long-term marrow culture by Schuening, FG, Storb, R, Stead, RB, Goehle, S, Nash, R, Miller, AD

“…Amphotropic helper-free retroviral vectors containing either the bacterial neomycin phosphotransferase gene (NEO) or a mutant dihydrofolate reductase gene…”
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T-Cell Subpopulations Identified by Monoclonal Antibodies After Human Marrow Transplantation. I. Helper-Inducer and Cytotoxic-Suppressor Subsets by Atkinson, Kerry, Hansen, John A., Storb, Rainer, Goehle, Sondra, Goldstein, Gideon, Thomas, E.Donnall

“…Peripheral blood helper–inducer and cytotoxic–suppressor T-cell subpopulations in patients receiving marrow transplants for the treatment of acute leukemia or…”
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Long-term culture of canine bone marrow cells by Schuening, F G, Storb, R, Meyer, J, Goehle, S

“…Conditions that allow the growth of canine marrow cells in long-term marrow culture are described. The quality of the culture conditions was evaluated based on…”
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Canine pluripotent hematopoietic stem cells and CFU-GM express Ia-like antigens as recognized by two different class II-specific monoclonal antibodies by SCHUENING, F, STORB, R, GOEHLE, S, MEYER, J, GRAHAM, T, DEEG, H. J, PESANDO, J

“…A previous study showed failure of autologous engraftment in lethally irradiated dogs when marrow was treated before infusion with anti-class II antibody 7.2…”
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Stimulation of canine hematopoiesis by recombinant human granulocyte-macrophage colony-stimulating factor by Schuening, F G, Storb, R, Goehle, S, Nash, R, Graham, T C, Appelbaum, F R, Hackman, R, Sandmaier, B M, Urdal, D L

“…The effect of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on canine hematopoiesis was evaluated. rhGM-CSF stimulated…”
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Facilitation of engraftment of DLA-nonidentical marrow by treatment of recipients with monoclonal antibody directed against marrow cells surviving radiation by Schuening, F, Storb, R, Goehle, S, Meyer, J, Graham, T C, Deeg, H J, Appelbaum, F R, Sale, G E, Graf, L, Loughran, Jr, T P

“…Past studies in dogs have suggested that marrow graft rejection was mediated by major histocompatibility complex (MHC) class II antigen-positive non-T cells…”
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Use of thymic grafts or thymic factors to augment immunologic recovery after bone marrow transplantation: brief report with 2 to 12 years' follow-up by Witherspoon, R P, Sullivan, K M, Lum, L G, Goehle, S, Atkinson, M K, Ochs, H D, Doney, K C, Hansen, J A, Sanders, J E, Storb, R

“…Thymus tissue implants, thymic epithelial cells obtained from third party donors sharing one HLA-A and -B locus with the recipient, or the thymic hormones…”
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Effect of recombinant human granulocyte colony-stimulating factor on hematopoiesis of normal dogs and on hematopoietic recovery after otherwise lethal total body irradiation by Schuening, FG, Storb, R, Goehle, S, Graham, TC, Appelbaum, FR, Hackman, R, Souza, LM

“…This study was designed to test whether recombinant human G-CSF (rh G- CSF) affects hematopoiesis in normal dogs and, if so, to test the effects of G-CSF in…”
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Increased gene transfer into human hematopoietic progenitor cells by extended in vitro exposure to a pseudotyped retroviral vector by von Kalle, C, Kiem, HP, Goehle, S, Darovsky, B, Heimfeld, S, Torok-Storb, B, Storb, R, Schuening, FG

“…Retroviral-mediated gene transfer is the most attractive modality for gene transfer into hematopoietic stem cells. However, transduction efficiency has been…”
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Increased Gene Transfer Into Human Hematopoietic Progenitor Cells by Extended In Vitro Exposure to a Pseudotyped Retroviral Vector by Kalle, Christof von, Kiem, Hans-Peter, Goehle, Sondra, Darovsky, Boris, Heimfeld, Shelly, Torok-Storb, Beverly, Storb, Rainer, Schuening, Friedrich G.

“…Retroviral-mediated gene transfer is the most attractive modality for gene transfer into hematopoietic stem cells. However, transduction efficiency has been…”
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Humoral immune response limits gene therapy in canine MPS I by Shull, R, Lu, X, Dubé, I, Lutzko, C, Kruth, S, Abrams-Ogg, A, Kiem, H P, Goehle, S, Schuening, F, Millan, C, Carter, R

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Thymidine incorporation is highly predictive of colony formation and can be used for high-throughput screening by Lamb, J R, Goehle, S, Ludlow, C, Simon, J A

“…The primary goal of anticancer chemotherapy is to kill cancer cells. Therefore, it is of critical importance that any assay that is used to determine the…”
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Retrovirus-mediated gene transduction into canine peripheral blood repopulating cells by KIEM, H.-P, DAROVSKY, B, STORB, R, SCHUENING, F. G, VON KALLE, C, GOEHLE, S, STEWART, D, GRAHAM, T, HACKMAN, R, APPELBAUM, F. R, DEEG, H. J, MILLER, A. D

“…Genetically marked peripheral blood progenitor cells were used to investigate their contribution to long-term hematopoietic reconstitution after autologous…”
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Retrovirus-mediated gene transduction into long-term repopulating marrow cells of dogs by SCHUENING, F. G, KAWAHARA, K, HACKMAN, R, OSBORNE, W. R. A, STORB, R, DUSTY MILLER, A, TO, R, GOEHLE, S, STEWART, D, MULLALLY, K, FISHER, L, GRAHAM, T. C, APPELBAUM, F. R

“…Amphotropic helper-free retrovirus vectors containing the bacterial neomycin phosphotransferase gene (neo) and the human adenosine deaminase gene (adenosine…”
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Myelosuppressive Conditioning Improves Autologous Engraftment of Genetically Marked Hematopoietic Repopulating Cells in Dogs by Barquinero, Jorge, Kiem, Hans-Peter, Kalle, Christof von, Darovsky, Boris, Goehle, Sondra, Graham, Ted, Seidel, Kristy, Storb, Rainer, Schuening, Friedrich G.

“…We have studied the role of different conditioning regimens for engraftment of genetically marked hematopoietic repopulating cells in dogs. Peripheral blood…”
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Long-term persistence of canine hematopoietic cells genetically marked by retrovirus vectors by Kiem, H P, Darovsky, B, Von Kalle, C, Goehle, S, Graham, T, Miller, A D, Storb, R, Schuening, F G

“…In 1991 we reported gene transduction into autologous long-term repopulating marrow cells in dogs using amphotropic helper-free retrovirus vectors containing…”
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