Search Results - "Goedert, Michel"

Tau pathology and neurodegeneration by Spillantini, Maria Grazia, Prof, Goedert, Michel, Dr

“…Summary The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and filamentous tau protein is at the centre of many human…”
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Propagation of Tau aggregates by Goedert, Michel, Spillantini, Maria Grazia

“…Since 2009, evidence has accumulated to suggest that Tau aggregates form first in a small number of brain cells, from where they propagate to other regions,…”
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Propagation of Tau Aggregates and Neurodegeneration by Goedert, Michel, Eisenberg, David S, Crowther, R. Anthony

“…A pathway from the natively unfolded microtubule-associated protein Tau to a highly structured amyloid fibril underlies human Tauopathies. This ordered…”
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The propagation of prion-like protein inclusions in neurodegenerative diseases by Goedert, Michel, Clavaguera, Florence, Tolnay, Markus

“…The most common neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, are characterized by the misfolding of a small number of…”
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Century of Alzheimer's Disease by Goedert, Michel, Spillantini, Maria Grazia

“…One hundred years ago a small group of psychiatrists described the abnormal protein deposits in the brain that define the most common neurodegenerative…”
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Structures of filaments from Pick’s disease reveal a novel tau protein fold by Falcon, Benjamin, Zhang, Wenjuan, Murzin, Alexey G., Murshudov, Garib, Garringer, Holly J., Vidal, Ruben, Crowther, R. Anthony, Ghetti, Bernardino, Scheres, Sjors H. W., Goedert, Michel

“…The ordered assembly of tau protein into abnormal filamentous inclusions underlies many human neurodegenerative diseases 1 . Tau assemblies seem to spread…”
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Galectin-8–mediated selective autophagy protects against seeded tau aggregation by Falcon, Benjamin, Noad, Jessica, McMahon, Harvey, Randow, Felix, Goedert, Michel

“…Assembled tau can transfer between cells and seed the aggregation of soluble tau. This process is thought to underlie the amplification and propagation of tau…”
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Structure-based classification of tauopathies by Shi, Yang, Zhang, Wenjuan, Yang, Yang, Murzin, Alexey G., Falcon, Benjamin, Kotecha, Abhay, van Beers, Mike, Tarutani, Airi, Kametani, Fuyuki, Garringer, Holly J., Vidal, Ruben, Hallinan, Grace I., Lashley, Tammaryn, Saito, Yuko, Murayama, Shigeo, Yoshida, Mari, Tanaka, Hidetomo, Kakita, Akiyoshi, Ikeuchi, Takeshi, Robinson, Andrew C., Mann, David M. A., Kovacs, Gabor G., Revesz, Tamas, Ghetti, Bernardino, Hasegawa, Masato, Goedert, Michel, Scheres, Sjors H. W.

“…The ordered assembly of tau protein into filaments characterizes several neurodegenerative diseases, which are called tauopathies. It was previously reported…”
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Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy by Schaeffer, Véronique, Goedert, Michel

“…The most common neurodegenerative diseases are characterized by the accumulation of misfolded proteins. Tauopathies, which include Alzheimer disease,…”
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Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases by Zhang, Wenjuan, Falcon, Benjamin, Murzin, Alexey G, Fan, Juan, Crowther, R Anthony, Goedert, Michel, Scheres, Sjors Hw

“…Assembly of microtubule-associated protein tau into filamentous inclusions underlies a range of neurodegenerative diseases. Tau filaments adopt different…”
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Brain homogenates from human tauopathies induce tau inclusions in mouse brain by Clavaguera, Florence, Akatsu, Hiroyasu, Fraser, Graham, Crowther, R. Anthony, Frank, Stephan, Hench, Jürgen, Probst, Alphonse, Winkler, David T., Reichwald, Julia, Staufenbiel, Matthias, Ghetti, Bernardino, Goedert, Michel, Tolnay, Markus

“…Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous human neurodegenerative diseases, including Alzheimer’s disease,…”
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Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy by Lövestam, Sofia, Koh, Fujiet Adrian, van Knippenberg, Bart, Kotecha, Abhay, Murzin, Alexey G, Goedert, Michel, Scheres, Sjors H W

“…Abundant filamentous inclusions of tau are characteristic of more than 20 neurodegenerative diseases that are collectively termed tauopathies. Electron…”
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Circadian clocks and neurodegenerative diseases: time to aggregate? by Hastings, Michael H, Goedert, Michel

“…Highlights • Neurodegenerative diseases are characterised by disordered sleep/wake patterns. • Aggregation of soluble proteins is the canonical molecular motif…”
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Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy by SCHAEFFER, Veronique, LAVENIR, Isabelle, OZCELIK, Sefika, TOLNAY, Markus, WINKLER, David T, GOEDERT, Michel

“…The accumulation of insoluble proteins is a pathological hallmark of several neurodegenerative disorders. Tauopathies are caused by the dysfunction and…”
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Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies by Goedert, Michel, Falcon, Ben, Clavaguera, Florence, Tolnay, Markus

“…Neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are characterized by the abnormal aggregation of a small number of…”
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Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging by Ghetti, Bernardino, Oblak, Adrian L., Boeve, Bradley F., Johnson, Keith A., Dickerson, Bradford C., Goedert, Michel

“…Hereditary frontotemporal dementia associated with mutations in the microtubule‐associated protein tau gene (MAPT) is a protean disorder. Three neuropathologic…”
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Age-dependent formation of TMEM106B amyloid filaments in human brains by Schweighauser, Manuel, Arseni, Diana, Bacioglu, Mehtap, Huang, Melissa, Lövestam, Sofia, Shi, Yang, Yang, Yang, Zhang, Wenjuan, Kotecha, Abhay, Garringer, Holly J., Vidal, Ruben, Hallinan, Grace I., Newell, Kathy L., Tarutani, Airi, Murayama, Shigeo, Miyazaki, Masayuki, Saito, Yuko, Yoshida, Mari, Hasegawa, Kazuko, Lashley, Tammaryn, Revesz, Tamas, Kovacs, Gabor G., van Swieten, John, Takao, Masaki, Hasegawa, Masato, Ghetti, Bernardino, Spillantini, Maria Grazia, Ryskeldi-Falcon, Benjamin, Murzin, Alexey G., Goedert, Michel, Scheres, Sjors H. W.

“…Many age-dependent neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, are characterized by abundant inclusions of amyloid filaments. Filamentous…”
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Transmission and spreading of tauopathy in transgenic mouse brain by Crowther, R. Anthony, Clavaguera, Florence, Abramowski, Dorothee, Goedert, Michel, Bolmont, Tristan, Probst, Alphonse, Tolnay, Markus, Fraser, Graham, Staufenbiel, Matthias, Stalder, Anna K, Jucker, Mathias, Beibel, Martin, Frank, Stephan

“…Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease. In the disease…”
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Invited review: Prion-like transmission and spreading of tau pathology by Clavaguera, Florence, Hench, Jürgen, Goedert, Michel, Tolnay, Markus

“…Filaments made of hyperphosphorylated tau protein are encountered in a number of neurodegenerative diseases referred to as ‘tauopathies’. In the most prevalent…”
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What is the evidence that tau pathology spreads through prion-like propagation? by Mudher, Amrit, Colin, Morvane, Dujardin, Simon, Medina, Miguel, Dewachter, Ilse, Alavi Naini, Seyedeh Maryam, Mandelkow, Eva-Maria, Mandelkow, Eckhard, Buée, Luc, Goedert, Michel, Brion, Jean-Pierre

“…Emerging experimental evidence suggests that the spread of tau pathology in the brain in Tauopathies reflects the propagation of abnormal tau species along…”
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