Search Results - "Goede, Jeroen"
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Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women
Published in Blood (22-10-2015)“…Iron supplements acutely increase hepcidin, but the duration and magnitude of the increase, its dose dependence, and its effects on subsequent iron absorption…”
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2
MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia
Published in Blood (03-11-2016)“…Although the molecular pathways that cause acute myeloid leukemia (AML) are increasingly well understood, the pathogenesis of peripheral blood cytopenia, a…”
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N-methyl-D-aspartate receptors in human erythroid precursor cells and in circulating red blood cells contribute to the intracellular calcium regulation
Published in American Journal of Physiology: Cell Physiology (01-12-2013)“…The presence of N-methyl-d-aspartate receptor (NMDAR) was previously shown in rat red blood cells (RBCs) and in a UT-7/Epo human myeloid cell line…”
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4
inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice
Published in Blood (27-10-2016)“…Favorable-risk human acute myeloid leukemia (AML) engrafts poorly in currently used immunodeficient mice, possibly because of insufficient environmental…”
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Donor Age and Red Cell Age Contribute to the Variance in Lorrca Indices in Healthy Donors for Next Generation Ektacytometry: A Pilot Study
Published in Frontiers in physiology (02-03-2021)“…The ability of red blood cells (RBCs) to transport gases, their lifespan as well as their rheological properties invariably depend on the deformability,…”
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6
Role of Piezo1 in Terminal Density Reversal of Red Blood Cells
Published in Cells (Basel, Switzerland) (01-08-2024)“…Density reversal of senescent red blood cells has been known for a long time, yet the identity of the candidate ion transporter(s) causing the senescent cells…”
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Feasibility of electronic patient-reported outcome monitoring and self-management program in aplastic anemia and paroxysmal nocturnal hemoglobinuria—a pilot study (ePRO-AA-PNH)
Published in Annals of hematology (01-01-2023)“…Introduction Electronic patient-reported outcomes (ePRO) are increasingly recognized in health care, as they have been demonstrated to improve patient outcomes…”
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Lysophosphatidic Acid-Activated Calcium Signaling Is Elevated in Red Cells from Sickle Cell Disease Patients
Published in Cells (Basel, Switzerland) (20-02-2021)“…(1) Background: It is known that sickle cells contain a higher amount of Ca compared to healthy red blood cells (RBCs). The increased Ca is associated with the…”
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9
Washing stored red blood cells in an albumin solution improves their morphologic and hemorheologic properties
Published in Transfusion (Philadelphia, Pa.) (01-08-2015)“…BACKGROUND Prolonged storage of red blood cells (RBCs) leads to storage lesions, which may impair clinical outcomes after transfusion. A hallmark of storage…”
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10
Hemoglobin is an oxygen-dependent glutathione buffer adapting the intracellular reduced glutathione levels to oxygen availability
Published in Redox biology (01-12-2022)“…Fast changes in environmental oxygen availability translate into shifts in mitochondrial free radical production. An increase in intraerythrocytic reduced…”
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Effect of osmolality on erythrocyte rheology and perfusion of an artificial microvascular network
Published in Microvascular research (01-03-2015)“…Plasma sodium concentration is normally held within a narrow range. It may however vary greatly under pathophysiological conditions. Changes in osmolality lead…”
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Red blood cells of sickle cell disease patients exhibit abnormally high abundance of N‐methyl D‐aspartate receptors mediating excessive calcium uptake
Published in British journal of haematology (01-10-2014)“…Summary Recently we showed that N‐methyl D‐aspartate receptors (NMDARs) are expressed in erythroid precursors (EPCs) and present in the circulating red blood…”
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Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome
Published in The Journal of experimental medicine (26-08-2013)“…The ubiquitously expressed iron storage protein ferritin plays a central role in maintaining cellular iron homeostasis. Cytosolic ferritins are composed of…”
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Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs
Published in The Journal of clinical investigation (01-08-2009)“…Release of hemoglobin (Hb) into the circulation is a central pathophysiologic event that contributes to morbidity and mortality in chronic hemolytic anemias…”
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Diagnosis and treatment of follicular lymphoma: an update
Published in Swiss medical weekly (01-01-2018)“…Over the last few years, there have been many changes in the management of patients with follicular lymphoma, resulting in improvements in progression-free…”
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R-hyper-CVAD versus R-CHOP/cytarabine with high-dose therapy and autologous haematopoietic stem cell support in fit patients with mantle cell lymphoma: 20 years of single-center experience
Published in Annals of hematology (01-02-2018)“…Standard of care for untreated mantle cell lymphoma (MCL) is still debated. At the University Hospital Zurich, advanced MCL in physically fit patients is…”
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Response to Tyrosine Kinase Inhibitors in Myeloproliferative Neoplasia with 8p11 Translocation and CEP110‐FGFR1 Rearrangement
Published in The oncologist (Dayton, Ohio) (01-04-2017)“…This brief communication reports on a patient with an exceedingly rare “8p11 (eight‐p‐eleven) myeloproliferative syndrome” (EMS) with CEP110‐FGFR1…”
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Influence of Standard Laboratory Procedures on Measures of Erythrocyte Damage
Published in Frontiers in physiology (29-09-2017)“…The ability to characterize the mechanical properties of erythrocytes is important in clinical and research contexts: to diagnose and monitor hematologic…”
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Functional plasticity of the N-methyl-d-aspartate receptor in differentiating human erythroid precursor cells
Published in American Journal of Physiology: Cell Physiology (15-06-2015)“…Calcium signaling is essential to support erythroid proliferation and differentiation. Precise control of the intracellular Ca(2+) levels in erythroid…”
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Patients with an extraordinarily elevated serum ferritin: think of haemophagocytic lymphohistiocytosis
Published in Swiss medical weekly (22-06-2015)“…We retrospectively analysed charts of patients with blood ferritin level >5000 µg/l. The aim of the study was to look for the likelihood of haemophagocytic…”
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