Search Results - "Goebels, J."

CTLA-4 blockade in murine bone marrow chimeras induces a host-derived antileukemic effect without graft-versus-host disease by FEVERY, S, BILLIAU, A. D, DE WOLF-PEETERS, C, WAER, M, VANDENBERGHE, P, SPRANGERS, B, RUTGEERTS, O, LENAERTSL, C, GOEBELS, J, LANDUYT, W, KASRAN, A, BOON, L, SAGAERT, X

“…We studied the effect of CTLA-4 blockade on graft-versus-leukemia and graft-versus-host responses in a mouse model of minor histocompatibility-mismatched bone…”
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An Easy and Reproducible Model of Kidney Transplantation in Rats by Soma, T, Lerut, E, Billiau, A, Waer, M, Goebels, J, Koshiba, T, Uemoto, S, Pirenne, J

“…Abstract Objective Kidney transplantation in rats is an important research model. Various methods have been reported, but there is no “standard operation.” We…”
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Transplantation Tolerance and Autoimmunity After Xenogeneic Thymus Transplantation by Xia, Guliang, Goebels, Jozef, Rutgeerts, Omer, Vandeputte, Michel, Waer, Mark

“…Successful grafting of vascularized xenografts (Xgs) depends on the ability to reliably induce both T cell-independent and -dependent immune tolerance. After…”
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Rejection of cardiac xenografts by NK cells and macrophages by Lin, Y., Goebels, J., Vandeputte, M., Waer, M.

“…DUE TO the nature of hyperacute rejection of xenografts transplanted between phylogenetically disparate species, cellular immune responses in…”
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The graft-versus-leukemia effect in allogeneic irradiation bone marrow chimeras: possible suppressive role of irradiation-induced TGF-β by Billiau, A.D, Sefrioui, H, Overbergh, L, Rutgeerts, O, Goebels, J, Waer, M

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Long-term survival of hamster-to-rat heart xenografts based on mechanisms of accommodation and tolerance of CD5 B cells by Lin, Y., Goebels, J., Vandeputte, M., Waer, M.

“…IT HAS now become possible to prevent hyperacute xenograft rejection by depletion and/or suppression of complement and/or xenoantibodies in a variety of…”
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The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines by Balzarini, J, Verstuyf, A, Hatse, S, Goebels, J, Sobis, H, Vandeputte, M, De Clercq, E

“…9-(2-phosphonylmethoxyethyl)adenine (PMEA) is the prototype compound of a series of acyclic nucleoside phosphonate derivatives endowed with potent and…”
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Immunosuppressants suppressing signal 2 of T-cell activation enable CsA to induce operational transplantation tolerance in a strongly immunogenic heart allograft model in rats by Lin, Y, Goebels, J, Vandeputte, M, Waer, M

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Increased Mortality and Impaired Clonal Deletion After Staphylococcal Enterotoxin B Injection in Old Mice: Relation to Cytokines and Nitric Oxide Production by KUSCHNAROFF, L. M., GOEBELS, J., VALCKX, D., HEREMANS, H., MATTHYS, P., WAER, M.

“…In the present study peripheral T cell tolerance and the occurrence of shock were evaluated in young and old mice after injection of Staphylococcal enterotoxin…”
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Effect of Treatments with Cyclosporin A and Anti‐Interferon‐γ Antibodies on the Mechanisms of Immune Tolerance in Staphylococcal Enterotoxin B Primed Mice by KUSCHNAROFF, L. M., VALCKX, D., GOEBELS, J., RUTGEERTS, O., HEREMANS, H., FROYENT, G., WAER, M.

“…The authors were interested to investigate the effect of Cyclosporin A (CsA), known to block interleukin‐2 (IL‐2) production, or of anti‐interferon‐γ…”
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Stable mixed chimerism induced by total lymphoid irradiation or by total body irradiation is maintained by different mechanisms and leads to different graft versus leukemia or graft rejection reactions by Sefrioui, H., Moodley, J., Rutgeerts, O., Goebels, J., Vandeputte, M., Waer, M.

“…ALLOGENEIC bone marrow (BM) transplantation is an effective procedure for the treatment of various malignant disorders of hematologic origin. 1,2 Several…”
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Characteristics of B lymphocyte and natural killer cell xenotolerance in a concordant hamster-to-athymic rat cardiac xenotransplantation model by Xia, G.L, Ji, P, Rutgeerts, O, Goebels, J, Waer, M

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Establishment and characterization of a continuous in vitro line from a rat choriocarcinoma by Verstuyf, A, Sobis, H, Goebels, J, Fonteyn, E, Cassiman, J J, Vandeputte, M

“…A continuous in vitro cell line of rat choriocarcinoma has been established. It is composed of pure trophoblast cells which multiply and differentiate. The…”
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Use of methylxanthines (MeXa) as immunosuppressive drugs for organ transplantation by Lin, Y., Schönharting, M., Goebels, J., Rutgeerts, O., Mikhalsky, D., Waer, M.

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Opposing effects of cyclosporin a and anti-interferon-γ antibodies on immune tolerance mechanisms by Kuschnaroff, L., Valckx, D., Froyen, G., Martens, E., Groenen, M., Goebels, J., Waer, M., Heremans, H.

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Influence of different growth factors on a rat choriocarcinoma cell line by Verstuyf, A, Goebels, J, Sobis, H, Vandeputte, M

“…The influence of epidermal growth factor, insulin-like growth factors I and II, insulin, transforming growth factor beta 1 and transferrin on the growth of a…”
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Histochemical and autoradiographic study of the cultured rat visceral yolk sac by SOBIS, H, GOEBELS, J, VANDEPUTTE, M

“…The proliferation and differentiation potentiality of the rat visceral yolk sac was investigated both in organ culture and after grafting in vivo . Using…”
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Inhibition of lymphocyte aggregation by progesterone by Van Vlasselaer, P, Goebels, J, Vandeputte, M

“…Investigations were carried out on the influence of progesterone and murine trophoblast culture supernatants on the capacity of lymphocytes to form aggregates…”
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Occurrence of Autoimmunity After Xenothymus Transplantation in T-Cell-Deficient Mice Depends on the Thymus Transplant Technique by DEVOS, Timothy, SPRANGERS, Ben, DE WOLF-PEETERS, Christiane, MATHIEU, Chantai, WAER, Mark, BILLIAU, An D, YUAN LIN, SHENGQIAO LI, YEHONG YAN, LANDUYT, Willy, LENAERTS, Caroline, RUTGEERTS, Omer, GOEBELS, Jozef, BULLENS, Dominique

“…Xenothymus transplantation under the kidney capsule in athymic rodents frequently leads to multiorgan autoimmunity. Herein, we explore whether this is an…”
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Effects of a short course of leflunomide on T-independent B-lymphocyte xenoreactivity and on susceptibility of xenografts to acute or chronic rejection by Yan, Yehong, Verbeken, Eric, Yu, Lisong, Rutgeerts, Omer, Goebels, Jozef, Segers, Constant, Lin, Yuan, Waer, Mark

“…Leflunomide is a novel immunosuppressive agent with promising activity for xenotransplantation. It is not clear yet which mechanisms of action of leflunomide…”
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