A Study of the Properties of Scaffolds for Bone Regeneration Modified with Gel-like Coatings of Chitosan and Folic Acid

A Study of the Properties of Scaffolds for Bone Regeneration Modified with Gel-like Coatings of Chitosan and Folic Acid

The research has been conducted to obtain scaffolds for cancellous bone regeneration. Polylactide scaffolds were made by the phase inversion method with a freeze-extraction variant, including gelling polylactide in its non-solvent. Substitutes made of polylactide are hydrophobic, which limits cell a...

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Bibliographic Details
Published in:Gels Vol. 9; no. 10; p. 773
Main Authors: Bandzerewicz, Aleksandra, Godzieba, Kamila, Wierzchowski, Kamil, Pilarek, Maciej, Gadomska-Gajadhur, Agnieszka
Format: Journal Article
Language:English
Published: Basel MDPI AG 23-09-2023
MDPI
Subjects:
Amino acids
Analysis
bone regeneration
Bones
Cell adhesion
Cell adhesion & migration
Chitosan
Coatings
Folic acid
Free flow
Mechanical properties
Nitrogen
Nutrients
Polylactic acid
polylactide
Porosity
Regeneration (physiology)
scaffold
Scaffolds
Spectrum analysis
Stem cells
Surface properties
Tissue engineering
Transplants & implants
Viscosity
Vitamin B
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Summary:The research has been conducted to obtain scaffolds for cancellous bone regeneration. Polylactide scaffolds were made by the phase inversion method with a freeze-extraction variant, including gelling polylactide in its non-solvent. Substitutes made of polylactide are hydrophobic, which limits cell adhesion. For this reason, the scaffolds were modified using chitosan and folic acid by forming gel-like coatings on the surface. The modification aimed to improve the material’s surface properties and increase cell adhesion. Analyses of obtained scaffolds confirmed the effectiveness of performed changes. The presence of chitosan and folic acid was confirmed in the modified scaffolds, while all scaffolds retained high open porosity, which is essential for proper cell growth inside the scaffold and the free flow of nutrients. Hydrostatic weighing showed that the scaffolds have high mass absorbability, allowing them to be saturated with biological fluids. There were also cytotoxicity tests performed on 24 h extracts of the materials obtained, which indicated a lack of cytotoxic effect.
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ISSN:2310-2861
2310-2861
DOI:10.3390/gels9100773