Search Results - "Godyń, Justyna"

Therapeutic strategies for Alzheimer's disease in clinical trials by Godyń, Justyna, Jończyk, Jakub, Panek, Dawid, Malawska, Barbara

“…Alzheimer's disease (AD) is considered to be the most common cause of dementia and is an incurable, progressive neurodegenerative disorder. Current treatment…”
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Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation by Panek, Dawid, Więckowska, Anna, Wichur, Tomasz, Bajda, Marek, Godyń, Justyna, Jończyk, Jakub, Mika, Kamil, Janockova, Jana, Soukup, Ondrej, Knez, Damijan, Korabecny, Jan, Gobec, Stanislav, Malawska, Barbara

“…The complexity of Alzheimer's disease (AD) calls for search of multifunctional compounds as potential candidates for effective therapy. A series of phthalimide…”
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Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives-Anticancer and Cholinesterase-Inhibiting Activity by Jończyk, Jakub, Godyń, Justyna, Stawarska, Ewelina, Morak-Młodawska, Beata, Jeleń, Małgorzata, Pluta, Krystian, Malawska, Barbara

“…The inverse correlation observed between Alzheimer's disease (AD) and cancer has prompted us to look for cholinesterase-inhibiting activity in phenothiazine…”
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1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease by Wichur, Tomasz, Więckowska, Anna, Więckowski, Krzysztof, Godyń, Justyna, Jończyk, Jakub, Valdivieso, Álvaro del Río, Panek, Dawid, Pasieka, Anna, Sabaté, Raimon, Knez, Damijan, Gobec, Stanislav, Malawska, Barbara

“…Complex pathomechanism of Alzheimer’s disease (AD) prompts researchers to develop multifunctional molecules in order to find effective therapy against AD. We…”
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Search for new multi-target compounds against Alzheimer's disease among histamine H 3 receptor ligands by Bajda, Marek, Łażewska, Dorota, Godyń, Justyna, Zaręba, Paula, Kuder, Kamil, Hagenow, Stefanie, Łątka, Kamil, Stawarska, Ewelina, Stark, Holger, Kieć-Kononowicz, Katarzyna, Malawska, Barbara

“…Multi-target-directed ligands seem to be an interesting approach to the treatment of complex disorders such as Alzheimer's disease. The aim of the present…”
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Design, Synthesis, and Biological Evaluation of 1‑Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer’s Agents by Panek, Dawid, Więckowska, Anna, Jończyk, Jakub, Godyń, Justyna, Bajda, Marek, Wichur, Tomasz, Pasieka, Anna, Knez, Damijan, Pišlar, Anja, Korabecny, Jan, Soukup, Ondrej, Sepsova, Vendula, Sabaté, Raimon, Kos, Janko, Gobec, Stanislav, Malawska, Barbara

“…The multitarget approach is a promising paradigm in drug discovery, potentially leading to new treatment options for complex disorders, such as Alzheimer’s…”
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Multifunctional agents against Alzheimer's disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions by Wei, Wenxiu, Jing, Lanlan, Tian, Ye, Więckowska, Anna, Kang, Dongwei, Meng, Bairu, Panek, Dawid, Godyń, Justyna, Góral, Izabella, Song, Yuning, Liu, Xinyong, Zhan, Peng

“…As Alzheimer's disease (AD) is a neurodegenerative disease with a complex pathogenesis, the exploration of multi-target drugs may be an effective strategy for…”
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Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents by Panek, Dawid, Więckowska, Anna, Pasieka, Anna, Godyń, Justyna, Jończyk, Jakub, Bajda, Marek, Knez, Damijan, Gobec, Stanislav, Malawska, Barbara

“…The complex nature of Alzheimer's disease calls for multidirectional treatment. Consequently, the search for multi-target-directed ligands may lead to…”
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New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition by Malek, Rim, Arribas, Raquel L, Palomino-Antolin, Alejandra, Totoson, Perle, Demougeot, Celine, Kobrlova, Tereza, Soukup, Ondrej, Iriepa, Isabel, Moraleda, Ignacio, Diez-Iriepa, Daniel, Godyń, Justyna, Panek, Dawid, Malawska, Barbara, Głuch-Lutwin, Monika, Mordyl, Barbara, Siwek, Agata, Chabchoub, Fakher, Marco-Contelles, José, Kiec-Kononowicz, Katarzyna, Egea, Javier, de los Ríos, Cristóbal, Ismaili, Lhassane

“…New tritarget small molecules combining Ca2+ channels blockade, cholinesterase, and H3 receptor inhibition were obtained by multicomponent synthesis. Compound…”
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4‑Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H3 Receptors and Cholinesterases by Michalska, Beata, Dzięgielewski, Marek, Godyń, Justyna, Werner, Tobias, Bajda, Marek, Karcz, Tadeusz, Szczepańska, Katarzyna, Stark, Holger, Więckowska, Anna, Walczyński, Krzysztof, Staszewski, Marek

“…This study examines the properties of a novel series of 4-oxypiperidines designed and synthesized as histamine H3R antagonists/inverse agonists based on the…”
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Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors by Malek, Rim, Sałat, Kinga, Totoson, Perle, Karcz, Tadeusz, Refouvelet, Bernard, Skrzypczak-Wiercioch, Anna, Maj, Maciej, Simakov, Alexey, Martin, Helene, Siwek, Agata, Szałaj, Natalia, Godyń, Justyna, Panek, Dawid, Więckowska, Anna, Jozwiak, Krzysztof, Demougeot, Celine, Kieć-Kononowicz, Katarzyna, Chabchoub, Fakher, Iriepa, Isabel, Marco-Contelles, José, Ismaili, Lhassane

“…At present, one of the most promising strategies to tackle the complex challenges posed by Alzheimer’s disease (AD) involves the development of novel…”
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Exploring Novel GSK-3β Inhibitors for Anti-Neuroinflammatory and Neuroprotective Effects: Synthesis, Crystallography, Computational Analysis, and Biological Evaluation by Góral, Izabella, Wichur, Tomasz, Sługocka, Emilia, Grygier, Przemysław, Głuch-Lutwin, Monika, Mordyl, Barbara, Honkisz-Orzechowska, Ewelina, Szałaj, Natalia, Godyń, Justyna, Panek, Dawid, Zaręba, Paula, Sarka, Anna, Żmudzki, Paweł, Latacz, Gniewomir, Pustelny, Katarzyna, Bucki, Adam, Czarna, Anna, Menezes, Filipe, Więckowska, Anna

“…In the pathogenesis of Alzheimer’s disease, the overexpression of glycogen synthase kinase-3β (GSK-3β) stands out due to its multifaced nature, as it…”
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Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer’s Disease by Więckowska, Anna, Wichur, Tomasz, Godyń, Justyna, Bucki, Adam, Marcinkowska, Monika, Siwek, Agata, Więckowski, Krzysztof, Zaręba, Paula, Knez, Damijan, Głuch-Lutwin, Monika, Kazek, Grzegorz, Latacz, Gniewomir, Mika, Kamil, Kołaczkowski, Marcin, Korabecny, Jan, Soukup, Ondrej, Benkova, Marketa, Kieć-Kononowicz, Katarzyna, Gobec, Stanislav, Malawska, Barbara

“…Alzheimer’s disease (AD) is a major public health problem, which is due to its increasing prevalence and lack of effective therapy or diagnostics. The…”
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Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies by Panek, Dawid, Pasieka, Anna, Latacz, Gniewomir, Zaręba, Paula, Szczęch, Michał, Godyń, Justyna, Chantegreil, Fabien, Nachon, Florian, Brazzolotto, Xavier, Skrzypczak-Wiercioch, Anna, Walczak, Maria, Smolik, Magdalena, Sałat, Kinga, Höfner, Georg, Wanner, Klaus, Więckowska, Anna, Malawska, Barbara

“…The symptomatic and disease-modifying effects of butyrylcholinesterase (BuChE) inhibitors provide an encouraging premise for researching effective treatments…”
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Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau by Wichur, Tomasz, Pasieka, Anna, Godyń, Justyna, Panek, Dawid, Góral, Izabella, Latacz, Gniewomir, Honkisz-Orzechowska, Ewelina, Bucki, Adam, Siwek, Agata, Głuch-Lutwin, Monika, Knez, Damijan, Brazzolotto, Xavier, Gobec, Stanislav, Kołaczkowski, Marcin, Sabate, Raimon, Malawska, Barbara, Więckowska, Anna

“…Multifunctional ligands as an essential variant of polypharmacology are promising candidates for the treatment of multi-factorial diseases like Alzheimer's…”
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Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative Diseases by Toledano-Pinedo, Mireia, Porro-Pérez, Alicia, Schäker-Hübner, Linda, Romero, Fernando, Dong, Min, Samadi, Abdelouahid, Almendros, Pedro, Iriepa, Isabel, Bautista-Aguilera, Òscar M., Rodríguez-Fernández, M. Mercedes, Solana-Manrique, Cristina, Sanchis, Inmaculada, Mora-Morell, Alba, Rodrìguez, Ania Canseco, Sànchez-Pérez, Ana M, Knez, Damijan, Gobec, Stanislav, Bellver-Sanchis, Aina, Pérez, Belén, Dobrydnev, Alexey V., Artetxe-Zurutuza, Aizpea, Matheu, Ander, Siwek, Agata, Wolak, Małgorzata, Satała, Grzegorz, Bojarski, Andrzej J., Doroz-Płonka, Agata, Handzlik, Jadwiga, Godyń, Justyna, Więckowska, Anna, Paricio, Nuria, Griñán-Ferré, Christian, Hansen, Finn K., Marco-Contelles, José

“…Herein, we describe the design, synthesis, and biological evaluation of 15 Contilisant+Tubastatin A hybrids. These ligands are polyfunctionalized indole…”
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Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy by Dgachi, Youssef, Sokolov, Olga, Luzet, Vincent, Godyń, Justyna, Panek, Dawid, Bonet, Alexandre, Martin, Hélène, Iriepa, Isabel, Moraleda, Ignacio, García-Iriepa, Cristina, Janockova, Jana, Richert, Lysiane, Soukup, Ondrej, Malawska, Barbara, Chabchoub, Fakher, Marco-Contelles, José, Ismaili, Lhassane

“…Herein we report an efficient two step synthesis and biological assessment of 12 racemic tetrahydropyranodiquinolin-8-amines derivatives as antioxidant,…”
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Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer’s Disease by Godyń, Justyna, Zaręba, Paula, Stary, Dorota, Kaleta, Maria, Kuder, Kamil J., Latacz, Gniewomir, Mogilski, Szczepan, Reiner-Link, David, Frank, Annika, Doroz-Płonka, Agata, Olejarz-Maciej, Agnieszka, Sudoł-Tałaj, Sylwia, Nolte, Tobias, Handzlik, Jadwiga, Stark, Holger, Więckowska, Anna, Malawska, Barbara, Kieć-Kononowicz, Katarzyna, Łażewska, Dorota, Bajda, Marek

“…The multitarget-directed ligands demonstrating affinity to histamine H3 receptor and additional cholinesterase inhibitory potency represent a promising…”
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Biphenylalkoxyamine Derivatives–Histamine H3 Receptor Ligands with Butyrylcholinesterase Inhibitory Activity by Łażewska, Dorota, Zaręba, Paula, Godyń, Justyna, Doroz-Płonka, Agata, Frank, Annika, Reiner-Link, David, Bajda, Marek, Stary, Dorota, Mogilski, Szczepan, Olejarz-Maciej, Agnieszka, Kaleta, Maria, Stark, Holger, Malawska, Barbara, Kieć-Kononowicz, Katarzyna

“…Neurodegenerative diseases, e.g., Alzheimer’s disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics…”
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Anti‐Alzheimer's multitarget‐directed ligands with serotonin 5‐HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity by Marcinkowska, Monika, Bucki, Adam, Panek, Dawid, Siwek, Agata, Fajkis, Nikola, Bednarski, Marek, Zygmunt, Małgorzata, Godyń, Justyna, Del Rio Valdivieso, Alvaro, Kotańska, Magdalena, Kołaczkowski, Marcin, Więckowska, Anna

“…Serotonin 5‐HT6 receptors, butyrylcholinesterase (BuChE) and oxidative stress are related to the pathophysiology of Alzheimer's disease. Inhibition of BuChE…”
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