Search Results - "Godwin, K"
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Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology
Published in Lab on a chip (07-10-2014)“…Developing blood-based tests is appealing for non-invasive disease diagnosis, especially when biopsy is difficult, costly, and sometimes not even an option…”
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Nested Association Mapping of Stem Rust Resistance in Wheat Using Genotyping by Sequencing
Published in PloS one (17-05-2016)“…We combined the recently developed genotyping by sequencing (GBS) method with joint mapping (also known as nested association mapping) to dissect and…”
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3
Delivery at an inadequate level of maternal care is associated with severe maternal morbidity
Published in American journal of obstetrics and gynecology (01-11-2024)“…Implementing levels of maternal care is one strategy proposed to reduce maternal morbidity and mortality. The levels of maternal care framework outline…”
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Triple-Negative Breast Cancer Risk Genes Identified by Multigene Hereditary Cancer Panel Testing
Published in JNCI : Journal of the National Cancer Institute (01-08-2018)“…Germline genetic testing with hereditary cancer gene panels can identify women at increased risk of breast cancer. However, those at increased risk of…”
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5
Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment
Published in Nature communications (06-10-2023)“…Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease…”
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Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury
Published in Nature communications (13-10-2016)“…WNT/β-catenin signalling is crucial for intestinal homoeostasis. The intestinal epithelium and stroma are the major source of WNT ligands but their origin and…”
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Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion
Published in Proceedings of the National Academy of Sciences - PNAS (14-01-2014)“…During tumor development, constant interplay occurs between tumor cells and surrounding stromal cells. We report evidence that gastrointestinal stromal tumor…”
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MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth
Published in Cancer research (Chicago, Ill.) (15-09-2007)“…MicroRNAs (miRNA) are a recently discovered class of noncoding RNAs that negatively regulate gene expression. Recent evidence indicates that miRNAs may play an…”
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Balancing conservation goals and ecotourism development in coastal wetland management in Sri Lanka: A choice experiment
Published in Ocean & coastal management (01-09-2021)“…Understanding the tradeoff between tourism development and environmental conservation is essential for the sustainable management of ecotourism. Accordingly,…”
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Exosomes as mediators of platinum resistance in ovarian cancer
Published in Oncotarget (14-02-2017)“…Exosomes have been implicated in the cell-cell transfer of oncogenic proteins and genetic material. We speculated this may be one mechanism by which an…”
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Reducing Ovarian Cancer Mortality Through Early Detection: Approaches Using Circulating Biomarkers
Published in Cancer prevention research (Philadelphia, Pa.) (01-03-2020)“…More than two-thirds of all women diagnosed with epithelial ovarian cancer (EOC) will die from the disease (>14,000 deaths annually), a fact that has not…”
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Reversible Cross-linked Thermoresponsive Polycaprolactone Micelles for Enhanced Stability and Controlled Release
Published in Biomacromolecules (11-12-2023)“…Thermoresponsive amphiphilic poly(ε-caprolactone)s (PCL)s are excellent candidates for drug delivery due to their biodegradability, biocompatibility, and…”
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High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study
Published in Scientific reports (07-12-2017)“…Pancreatic cancer is among the most lethal cancers with poorly tolerated treatments. There is increasing interest in using high-dose intravenous ascorbate…”
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14
Maleimide functionalized polycaprolactone micelles for glutathione quenching and doxorubicin delivery
Published in Chemical science (Cambridge) (03-07-2024)“…High glutathione production is known to be one of the defense mechanisms by which many cancer cells survive elevated oxidative stress. By explicitly targeting…”
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Entomological surveillance on Aedes aegypti during covid 19 period in Cape Coast, Ghana: Risk of arboviral outbreaks, multiple insecticide resistance and distribution of F1534C, V410L and V1016I kdr mutations
Published in PLoS neglected tropical diseases (01-05-2023)“…The study assessed the risk of transmission of Aedes-borne arboviruses in a community at Cape Coast during the Covid-19 restriction period in 2020 based on…”
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Repertoire of microRNAs in epithelial ovarian cancer as determined by next generation sequencing of small RNA cDNA libraries
Published in PloS one (23-04-2009)“…MicroRNAs (miRNAs) are small regulatory RNAs that are implicated in cancer pathogenesis and have recently shown promise as blood-based biomarkers for cancer…”
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Effective inhibition of c-MET-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment
Published in Oncogene (08-01-2015)“…The signaling mediated by c-MET and its ligand, hepatocyte growth factor (HGF), has been implicated in malignant progression of cancer involving stimulation of…”
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Standard Operating Procedures for Serum and Plasma Collection: Early Detection Research Network Consensus Statement Standard Operating Procedure Integration Working Group
Published in Journal of proteome research (01-01-2009)“…Specimen collection is an integral component of clinical research. Specimens from subjects with various stages of cancers or other conditions, as well as those…”
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Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers
Published in Critical reviews in oncology/hematology (01-02-2014)“…Abstract The mechanisms underlying malignant cell metastasis to secondary sites such as bone are complex and no doubt multifactorial. Members of the small…”
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A Unique Spectrum of Somatic PIK3CA (p110α) Mutations Within Primary Endometrial Carcinomas
Published in Clinical cancer research (15-03-2011)“…The goal of this study was to comprehensively define the incidence of mutations in all exons of PIK3CA in both endometrioid endometrial cancer (EEC) and…”
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