Search Results - "Godwin, Alan R F"

Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFβ-binding site by Godwin, Alan R. F., Dajani, Rana, Zhang, Xinyang, Thomson, Jennifer, Holmes, David F., Adamo, Christin S., Sengle, Gerhard, Sherratt, Michael J., Roseman, Alan M., Baldock, Clair

“…Genetic mutations in fibrillin microfibrils cause serious inherited diseases, such as Marfan syndrome and Weill–Marchesani syndrome (WMS). These diseases…”
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Publisher Correction: Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFβ-binding site by Godwin, Alan R. F., Dajani, Rana, Zhang, Xinyang, Thomson, Jennifer, Holmes, David F., Adamo, Christin S., Sengle, Gerhard, Sherratt, Michael J., Roseman, Alan M., Baldock, Clair

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The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly by Godwin, Alan R.F., Singh, Mukti, Lockhart-Cairns, Michael P., Alanazi, Yasmene F., Cain, Stuart A., Baldock, Clair

“…Fibrillin is a large evolutionarily ancient extracellular glycoprotein that assembles to form beaded microfibrils which are essential components of most…”
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Defining the hierarchical organisation of collagen VI microfibrils at nanometre to micrometre length scales by Godwin, Alan R.F., Starborg, Tobias, Sherratt, Michael J., Roseman, Alan M., Baldock, Clair

“…[Display omitted] Extracellular matrix microfibrils are critical components of connective tissues with a wide range of mechanical and cellular signalling…”
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Internal cleavage and synergy with twisted gastrulation enhance BMP inhibition by BMPER by Lockhart-Cairns, Michael P., Lim, Karen Tzia Wei, Zuk, Alexandra, Godwin, Alan R.F., Cain, Stuart A., Sengle, Gerhard, Baldock, Clair

“…Bone morphogenetic proteins (BMPs) are essential signalling molecules involved in developmental and pathological processes and are regulated in the matrix by…”
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ADAMTS10-mediated tissue disruption in Weill-Marchesani syndrome by Mularczyk, Ewa J, Singh, Mukti, Godwin, Alan R F, Galli, Francessco, Humphreys, Neil, Adamson, Antony D, Mironov, Aleksandr, Cain, Stuart A, Sengle, Gerhard, Boot-Handford, Ray P, Cossu, Giulio, Kielty, Cay M, Baldock, Clair

“…Abstract Fibrillin microfibrils are extracellular matrix assemblies that form the template for elastic fibres, endow blood vessels, skin and other elastic…”
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Dual role of the active site ‘lid’ regions of protochlorophyllide oxidoreductase in photocatalysis and plant development by Zhang, Shaowei, Godwin, Alan R. F., Taylor, Aoife, Hardman, Samantha J. O., Jowitt, Thomas A., Johannissen, Linus O., Hay, Sam, Baldock, Clair, Heyes, Derren J., Scrutton, Nigel S.

“…The structure of light‐dependent protochlorophyllide oxidoreductase (POR) suggests that amino acid residues in highly conserved active site ‘lid’ regions are…”
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A new MMP‐mediated prodomain cleavage mechanism to activate bone morphogenetic proteins from the extracellular matrix by Furlan, Ariane G., Spanou, Chara E. S., Godwin, Alan R. F., Wohl, Alexander P., Zimmermann, Laura‐Marie A., Imhof, Thomas, Koch, Manuel, Baldock, Clair, Sengle, Gerhard

“…Since their discovery as pluripotent cytokines extractable from bone matrix, it has been speculated how bone morphogenetic proteins (BMPs) become released and…”
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Multiscale Imaging Reveals the Hierarchical Organization of Fibrillin Microfibrils by Godwin, Alan R.F., Starborg, Tobias, Smith, David J., Sherratt, Michael J., Roseman, Alan M., Baldock, Clair

“…Fibrillin microfibrils are evolutionarily ancient, structurally complex extracellular polymers found in mammalian elastic tissues where they endow elastic…”
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Structural studies of elastic fibre and microfibrillar proteins by Singh, Mukti, Becker, Mark, Godwin, Alan R.F., Baldock, Clair

“…Elastic tissues owe their functional properties to the composition of their extracellular matrices, particularly the range of extracellular, multidomain…”
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