Search Results - "Godwin, A K"

Effective inhibition of c-MET-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment by Kwon, Y, Smith, B D, Zhou, Y, Kaufman, M D, Godwin, A K

“…The signaling mediated by c-MET and its ligand, hepatocyte growth factor (HGF), has been implicated in malignant progression of cancer involving stimulation of…”
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The histone demethylase KDM4B regulates peritoneal seeding of ovarian cancer by Wilson, C, Qiu, L, Hong, Y, Karnik, T, Tadros, G, Mau, B, Ma, T, Mu, Y, New, J, Louie, R J, Gunewardena, S, Godwin, A K, Tawfik, O W, Chien, J, Roby, K F, Krieg, A J

“…Epithelial ovarian cancer (EOC) has poor prognosis and rapid recurrence because of widespread dissemination of peritoneal metastases at diagnosis. Multiple…”
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Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion by Do, T-V, Xiao, F, Bickel, L E, Klein-Szanto, A J, Pathak, H B, Hua, X, Howe, C, O'Brien, S W, Maglaty, M, Ecsedy, J A, Litwin, S, Golemis, E A, Schilder, R J, Godwin, A K, Connolly, D C

“…Aurora kinase A (AURKA) localizes to centrosomes and mitotic spindles where it mediates mitotic progression and chromosomal stability. Overexpression of AURKA…”
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Breast Cancer Risk After Bilateral Prophylactic Oophorectomy in BRCA1 Mutation Carriers by Rebbeck, Timothy R., Levin, Albert M., Eisen, Andrea, Snyder, Carrie, Watson, Patrice, Cannon-Albright, Lisa, Isaacs, Claudine, Olopade, Olofunmilayo, Garber, Judy E., Godwin, Andrew K., Daly, Mary B., Narod, Steven A., Neuhausen, Susan L., Lynch, Henry T., Weber, Barbara L.

“…BACKGROUND: The availability of genetic testing for inherited mutations in the BRCA1 gene provides potentially valuable information to women at high risk of…”
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Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer by Dotan, E, Meropol, N J, Zhu, F, Zambito, F, Bove, B, Cai, K Q, Godwin, A K, Golemis, E A, Astsaturov, I, Cohen, S J

“…Background: Increased Aurora kinase A gene copy number ( AURKA-CN ) has been reported in metastatic colorectal cancer (mCRC), with unknown relationship to…”
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A nonrandom association of gastrointestinal stromal tumor (GIST) and desmoid tumor (deep fibromatosis): case series of 28 patients by Dumont, A.G., Rink, L., Godwin, A.K., Miettinen, M., Joensuu, H., Strosberg, J.R., Gronchi, A., Corless, C.L., Goldstein, D., Rubin, B.P., Maki, R.G., Lazar, A.J., Lev, D., Trent, J.C., von Mehren, M.

“…Gastrointestinal stromal tumors (GISTs) and desmoid tumors (DTs) are two rare mesenchymal tumor. Anecdotal reports of individuals with both diseases led us to…”
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The role of the c-Jun N-terminal kinase 2-α-isoform in non-small cell lung carcinoma tumorigenesis by Nitta, R T, Del Vecchio, C A, Chu, A H, Mitra, S S, Godwin, A K, Wong, A J

“…The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase family and have been implicated in tumorigenesis. One isoform in…”
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Mutation detection using a novel plant endonuclease by Oleykowski, Catherine A., Bronson Mullins, Colleen R., Godwin, Andrew K., Yeung, Anthony T.

“…We have discovered a useful new reagent for mutation detection, a novel nuclease CEL I from celery. It is specific for DNA distortions and mismatches from pH 6…”
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Microscopic Benign and Invasive Malignant Neoplasms and a Cancer-Prone Phenotype in Prophylactic Oophorectomies by Salazar, Hernando, Godwin, Andrew K., Daly, Mary B., Laub, Paul B., Hogan, W. Michael, Rosenblum, Norman, Boente, Matthew P., Lynch, Henry T., Hamilton, Thomas C.

“…Background The occurrence of approximately 5% of common epithelial malignant tumors of the ovary can be traced to inheritance of risk. One prohylactic strategy…”
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A phase II evaluation of motesanib (AMG 706) in the treatment of persistent or recurrent ovarian, fallopian tube and primary peritoneal carcinomas: A Gynecologic Oncology Group study by Schilder, R.J, Sill, M.W, Lankes, H.A, Gold, M.A, Mannel, R.S, Modesitt, S.C, Hanjani, P, Bonebrake, A.J, Sood, A.K, Godwin, A.K, Hu, W, Alpaugh, R.K

“…Abstract Objectives Vascular endothelial growth factors (VEGF) and their receptors have a critical role in stimulating the growth of ovarian cancer cells…”
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High Resistance to Cisplatin in Human Ovarian Cancer Cell Lines is Associated with Marked Increase of Glutathione Synthesis by Godwin, Andrew K., Meister, Alton, O'Dwyer, Peter J., Huang, Chin Shiou, Hamilton, Thomas C., Anderson, Mary E.

“…Exposure of human ovarian tumor cell lines to cisplatin led to development of cell lines that exhibited increasing degrees of drug resistance, which were…”
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A novel epidermal growth factor receptor variant lacking multiple domains directly activates transcription and is overexpressed in tumors by Piccione, E C, Lieu, T J, Gentile, C F, Williams, T R, Connolly, A J, Godwin, A K, Koong, A C, Wong, A J

“…The epidermal growth factor receptor (EGFR) is essential to multiple physiological and neoplastic processes via signaling by its tyrosine kinase domain and…”
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Impact of homologous recombination deficiency biomarkers on outcomes in patients with triple-negative breast cancer treated with adjuvant doxorubicin and cyclophosphamide (SWOG S9313) by Sharma, P., Barlow, W.E., Godwin, A.K., Pathak, H., Isakova, K., Williams, D., Timms, K.M., Hartman, A.R., Wenstrup, R.J., Linden, H.M., Tripathy, D., Hortobagyi, G.N., Hayes, D.F.

“…Homologous recombination deficiency (HRD)-causing alterations have been reported in triple-negative breast cancer (TNBC). We hypothesized that TNBCs with HRD…”
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AKT2, A Putative Oncogene Encoding a Member of a Subfamily of Protein- Serine/Threonine Kinases, is Amplified in Human Ovarian Carcinomas by Cheng, Jin Quan, Godwin, Andrew K., Bellacosa, Alfonso, Taguchi, Takahiro, Franke, Thomas F., Hamilton, Thomas C., Tsichlis, Philip N., Testa, Joseph R.

“…We isolated cDNA clones containing the entire coding region of the putative oncogene AKT2. Sequence analysis and in vitro translation demonstrated that AKT2…”
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A Grb2-associated docking protein in EGF- and insulin-receptor signalling by Holgado-Madruga, Marina, Emlet, David R, Moscatello, David K, Godwin, Andrew K, Wong, Albert J

“…The protein Grb2 plays a central role in signalling by receptor protein-tyrosine kinases, where its SH2 domain binds to the receptor and its two SH3 domains…”
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Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors by MOSCATELLO, D. K, HOLGADO-MADRUGA, M, GODWIN, A. K, RAMIREZ, G, GUNN, G, ZOLTICK, P. W, BIEGEL, J. A, HAYES, R. L, WONG, A. J

“…The epidermal growth factor receptor has received much interest as a target for various antineoplastic agents, but a complication is that many normal tissues…”
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Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas by Bellacosa, A, de Feo, D, Godwin, A K, Bell, D W, Cheng, J Q, Altomare, D A, Wan, M, Dubeau, L, Scambia, G, Masciullo, V, Ferrandina, G, Benedetti Panici, P, Mancuso, S, Neri, G, Testa, J R

“…The AKT2 gene is one of the human homologues of v-akt, the transduced oncogene of the AKT8 virus, which induces lymphomas in mice. In previous studies, AKT2,…”
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Modification of BRCA1-Associated Breast Cancer Risk by the Polymorphic Androgen-Receptor CAG Repeat by Rebbeck, Timothy R., Kantoff, Philip W., Krithivas, Krishna, Neuhausen, Susan, Blackwood, M. Anne, Godwin, Andrew K., Daly, Mary B., Narod, Steven A., Garber, Judy E., Lynch, Henry T., Weber, Barbara L., Brown, Myles

“…Compared with the general population, women who have inherited a germline mutation in the BRCA1 gene have a greatly increased risk of developing breast cancer…”
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Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary by Bruening, Wendy, Giasson, Benoit I., Klein‐Szanto, Andres J. P., Lee, Virginia M.‐Y., Trojanowski, John Q., Godwin, Andrew K.

“…BACKGROUND The synucleins (α, β, and γ) are a family of small cytoplasmic proteins that are expressed predominantly in neurons. α synuclein has attracted…”
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FOXA1 represses the molecular phenotype of basal breast cancer cells by Bernardo, G M, Bebek, G, Ginther, C L, Sizemore, S T, Lozada, K L, Miedler, J D, Anderson, L A, Godwin, A K, Abdul-Karim, F W, Slamon, D J, Keri, R A

“…Breast cancer is a heterogeneous disease that comprises multiple subtypes. Luminal subtype tumors confer a more favorable patient prognosis, which is, in part,…”
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