Search Results - "Godsave, Susan"

Prion uptake in the gut: identification of the first uptake and replication sites by Kujala, Pekka, Raymond, Claudine R, Romeijn, Martijn, Godsave, Susan F, van Kasteren, Sander I, Wille, Holger, Prusiner, Stanley B, Mabbott, Neil A, Peters, Peter J

“…After oral exposure, prions are thought to enter Peyer's patches via M cells and accumulate first upon follicular dendritic cells (FDCs) before spreading to…”
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Subcellular distribution of the prion protein in sickness and in health by Godsave, Susan F., Peters, Peter J., Wille, Holger

“…•The subcellular distribution of PrP affects its function and pathogenic conversion.•Endogenous proteolysis may regulate function and pathogenic…”
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Plasma membrane invaginations containing clusters of full-length PrPSc are an early form of prion-associated neuropathology in vivo by Godsave, Susan F, Wille, Holger, Pierson, Jason, Prusiner, Stanley B, Peters, Peter J

“…Abstract During prion disease, cellular prion protein (PrPC ) is refolded into a pathogenic isoform (PrPSc ) that accumulates in the central nervous system and…”
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Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs by Rouvinski, Alexander, Karniely, Sharon, Kounin, Maria, Moussa, Sanaa, Goldberg, Miri D, Warburg, Gabriela, Lyakhovetsky, Roman, Papy-Garcia, Dulce, Kutzsche, Janine, Korth, Carsten, Carlson, George A, Godsave, Susan F, Peters, Peter J, Luhr, Katarina, Kristensson, Krister, Taraboulos, Albert

“…Mammalian prions refold host glycosylphosphatidylinositol-anchored PrP(C) into β-sheet-rich PrP(Sc). PrP(Sc) is rapidly truncated into a C-terminal PrP27-30…”
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Cryo-Immunogold Electron Microscopy for Prions: Toward Identification of a Conversion Site by Godsave, Susan F, Wille, Holger, Kujala, Pekka, Latawiec, Diane, DeArmond, Stephen J, Serban, Ana, Prusiner, Stanley B, Peters, Peter J

“…Prion diseases are caused by accumulation of an abnormally folded isoform (PrP(Sc)) of the cellular prion protein (PrP(C)). The subcellular distribution of…”
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Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent‐resistant membrane compartments by Klingenstein, Ralf, Löber, Stefan, Kujala, Pekka, Godsave, Susan, Leliveld, S. Rutger, Gmeiner, Peter, Peters, Peter J., Korth, Carsten

“…Prion diseases are invariably fatal, neurodegenerative diseases transmitted by an infectious agent, PrPSc, a pathogenic, conformational isoform of the normal…”
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Androgen receptors in the embryonic zebra finch hindbrain suggest a function for maternal androgens in perihatching survival by Godsave, Susan F., Lohmann, Ragna, Vloet, Rianka P.M., Gahr, Manfred

“…Bird embryos are exposed to maternal androgens deposited in the egg, but the role of these hormones in embryonic development and hatchling survival is unclear…”
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Toward visualization of nanomachines in their native cellular environment by Pierson, Jason, Sani, Musa, Tomova, Cveta, Godsave, Susan, Peters, Peter J

“…The cellular nanocosm is made up of numerous types of macromolecular complexes or biological nanomachines. These form functional modules that are organized…”
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XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos by Molenaar, Miranda, van de Wetering, Marc, Oosterwegel, Mariette, Peterson-Maduro, Josi, Godsave, Susan, Korinek, Vladimir, Roose, Jeroen, Destrée, Olivier, Clevers, Hans

“…XTcf-3 is a maternally expressed Xenopus homolog of the mammalian HMG box factors Tcf-1 and Lef-1. The N-terminus of XTcf-3 binds to β-catenin. Microinjection…”
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Live imaging of prions reveals nascent PrP^sup Sc^ in cell-surface, raft-associated amyloid strings and webs by Rouvinski, Alexander, Karniely, Sharon, Kounin, Maria, Moussa, Sanaa, Goldberg, Miri D, Warburg, Gabriela, Lyakhovetsky, Roman, Papy-Garcia, Dulce, Kutzsche, Janine, Korth, Carsten, Carlson, George A, Godsave, Susan F, Peters, Peter J, Luhr, Katarina, Kristensson, Krister, Taraboulos, Albert

“…Mammalian prions refold host glycosylphosphatidylinositol-anchored PrP... into β-sheet-rich PrP... PrP... is rapidly truncated into a C-terminal PrP27-30 core…”
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Live imaging of prions reveals nascent PrP super( Sc) in cell-surface, raft-associated amyloid strings and webs by Rouvinski, Alexander, Karniely, Sharon, Kounin, Maria, Moussa, Sanaa, Goldberg, Miri D, Warburg, Gabriela, Lyakhovetsky, Roman, Papy-Garcia, Dulce, Kutzsche, Janine, Korth, Carsten, Carlson, George A, Godsave, Susan F, Peters, Peter J, Luhr, Katarina, Kristensson, Krister, Taraboulos, Albert

“…Mammalian prions refold host glycosylphosphatidylinositol-anchored PrP... into beta -sheet-rich PrP... PrP... is rapidly truncated into a C-terminal PrP27-30…”
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Nuclear translocation of fibroblast growth factor during Xenopus mesoderm induction by SHIURBA, R. A, NAIHE JING, SAKAKURA, T, GODSAVE, S. F

“…Mesoderm induction, the earliest inductive cell-cell interaction in vertebrate embryogenesis, is thought to be mediated by polypeptide growth factors including…”
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Expression Patterns of Hoxb Genes in the Xenopus Embryo Suggest Roles in Anteroposterior Specification of the Hindbrain and in Dorsoventral Patterning of the Mesoderm by Godsave, Susan, Dekker, Erik-Jan, Holling, Tjadine, Pannese, Maria, Boncinelli, Edoardo, Durston, Antony

“…Hox genes are thought to participate in patterning the anteroposterior (a-p) axis during vertebrate embryogenesis. In this investigation, the spatial…”
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Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent‐resistant membrane compartments by Klingenstein, Ralf, Löber, Stefan, Kujala, Pekka, Godsave, Susan, Leliveld, S. Rutger, Gmeiner, Peter, Peters, Peter J., Korth, Carsten

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CORRIGENDUM: Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments by Klingenstein, Ralf, Löber, Stefan, Kujala, Pekka, Godsave, Susan, Leliveld, S Rutger, Gmeiner, Peter, Peters, Peter J, Korth, Carsten

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Oocytes and early embryos of Xenopus laevis contain intermediate filaments which react with anti-mammalian vimentin antibodies by GODSAVE, S. F, ANDERTON, B. H, HEASMAN, J, WYLIE, C. C

“…Previous studies have shown that Xenopus oocytes possess a cortical shell, which includes actin-containing microfilaments and cytokeratin-containing…”
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Neural induction and patterning in embryos deficient in FGF signaling by Godsave, S F, Durston, A J

“…We have examined the role of FGFs in neural induction and posteriorization of the central nervous system (CNS). Using embryos micro-injected with dominant…”
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Xenopus blastulae show regional differences in competence for mesoderm induction: Correlation with endogenous basic fibroblast growth factor levels by Godsave, Susan F., Shiurba, Robert A.

“…Single cells from the animal cap and marginal zone (MZ) of mid-blastula stage embryos can undergo mesodermal or ectodermal differentiation as small clones…”
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Developmental expression and differential regulation by retinoic acid of Xenopus COUP-TF-A and COUP-TF-B by van der Wees, Jacqueline, Matharu, Philip J., de Roos, Koen, Destre´e, Olivier H.J., Godsave, Susan F., Durston, Antony J., Sweeney, Glen E.

“…COUP-TFs (Chicken Ovalbumin Upstream Promoter Transcription Factors) have been proposed to be negative regulators of retinoid receptor-mediated transcriptional…”
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Developmental expression and differential regulation by retinoic acid ofXenopus COUP-TF-A andCOUP-TF-B by van der Wees, Jacqueline, Matharu, Philip J., de Roos, Koen, Destre´e, Olivier H.J., Godsave, Susan F., Durston, Antony J., Sweeney, Glen E.

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