Search Results - "Godornes, Charmie"

Two Mutations Associated With Macrolide Resistance in Treponema pallidum: Increasing Prevalence and Correlation With Molecular Strain Type in Seattle, Washington by Grimes, Matthew, Sahi, Sharon K., Godornes, B. Charmie, Tantalo, Lauren C., Roberts, Neal, Bostick, David, Marra, Christina M., Lukehart, Sheila A.

“…Background: Although azithromycin promised to be a safe and effective single-dose oral treatment of early syphilis, azithromycin treatment failure has been…”
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Haemophilus ducreyi as a cause of skin ulcers in children from a yaws-endemic area of Papua New Guinea: a prospective cohort study by Mitjà, Oriol, Dr, Lukehart, Sheila A, Prof, Pokowas, Gideon, HEO, Moses, Penias, HEO, Kapa, August, BSc, Godornes, Charmie, BSc, Robson, Jennifer, MD, Cherian, Sarah, MD, Houinei, Wendy, HEO, Kazadi, Walter, MD, Siba, Peter, Prof, de Lazzari, Elisa, MSc, Bassat, Quique, MD

“…Summary Background Skin infections with ulceration are a major health problem in countries of the south Pacific region. Yaws, caused by Treponema pallidum…”
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Mass Treatment with Single-Dose Azithromycin for Yaws by Mitjà, Oriol, Houinei, Wendy, Moses, Penias, Kapa, August, Paru, Raymond, Hays, Russell, Lukehart, Sheila, Godornes, Charmie, Bieb, Sibauk Vivaldo, Grice, Tim, Siba, Peter, Mabey, David, Sanz, Sergi, Alonso, Pedro L, Asiedu, Kingsley, Bassat, Quique

“…Yaws, an infectious disease caused by Treponema pallidum subspecies pertenue, is endemic in many parts of the world. A community-wide treatment program in…”
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B-Cell Epitope Mapping of TprC and TprD Variants of Treponema pallidum Subspecies Informs Vaccine Development for Human Treponematoses by Molini, Barbara, Fernandez, Mark C, Godornes, Charmie, Vorobieva, Anastassia, Lukehart, Sheila A, Giacani, Lorenzo

“…Several recent studies have focused on the identification, functional analysis, and structural characterization of outer membrane proteins (OMPs) of ( ). The…”
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Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea by Godornes, Charmie, Giacani, Lorenzo, Barry, Alyssa E, Mitja, Oriol, Lukehart, Sheila A

“…Yaws is a neglected tropical disease, caused by Treponema pallidum subsp. pertenue. The disease causes chronic lesions, primarily in young children living in…”
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Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains by Centurion-Lara, Arturo, Giacani, Lorenzo, Godornes, Charmie, Molini, Barbara J, Brinck Reid, Tara, Lukehart, Sheila A

“…The pathogenic non-cultivable treponemes include three subspecies of Treponema pallidum (pallidum, pertenue, endemicum), T. carateum, T. paraluiscuniculi, and…”
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Antigenic Variation in Treponema pallidum: TprK Sequence Diversity Accumulates in Response to Immune Pressure during Experimental Syphilis by Giacani, Lorenzo, Molini, Barbara J, Kim, Eric Y, Godornes, B. Charmie, Leader, B. Troy, Tantalo, Lauren C, Centurion-Lara, Arturo, Lukehart, Sheila A

“…Pathogens that cause chronic infections often employ antigenic variation to evade the immune response and persist in the host. In Treponema pallidum (T…”
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Macrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains by Molini, Barbara J., Tantalo, Lauren C., Sahi, Sharon K., Rodriguez, Veronica I., Brandt, Stephanie L., Fernandez, Mark C., Godornes, Charmie B., Marra, Christina M., Lukehart, Sheila A.

“…BACKGROUNDHigh rates of 23S rDNA mutations implicated in macrolide resistance have been identified in Treponema pallidum samples from syphilis patients in many…”
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Comparative Investigation of the Genomic Regions Involved in Antigenic Variation of the TprK Antigen among Treponemal Species, Subspecies, and Strains by Giacani, Lorenzo, Brandt, Stephanie L, Puray-Chavez, Maritza, Reid, Tara Brinck, Godornes, Charmie, Molini, Barbara J, Benzler, Martin, Hartig, Jörg S, Lukehart, Sheila A, Centurion-Lara, Arturo

“…Although the three Treponema pallidum subspecies (T. pallidum subsp. pallidum, T. pallidum subsp. pertenue, and T. pallidum subsp. endemicum), Treponema…”
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Streptococcus pyogenes Is Associated with Idiopathic Cutaneous Ulcers in Children on a Yaws-Endemic Island by Griesenauer, Brad, González-Beiras, Camila, Fortney, Katherine R, Lin, Huaiying, Gao, Xiang, Godornes, Charmie, Nelson, David E, Katz, Barry P, Lukehart, Sheila A, Mitjà, Oriol, Dong, Qunfeng, Spinola, Stanley M

“…Exudative cutaneous ulcers (CU) in yaws-endemic areas are associated with subsp. (TP) and (HD), but one-third of CU cases are idiopathic (IU). Using mass drug…”
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Topical treatment with gallium maltolate reduces Treponema pallidum subsp. pertenue burden in primary experimental lesions in a rabbit model of yaws by Giacani, Lorenzo, Bernstein, Lawrence R, Haynes, Austin M, Godornes, B Charmie, Ciccarese, Giulia, Drago, Francesco, Parodi, Aurora, Valdevit, Sefora, Anselmi, Luca, Tomasini, Carlo Francesco, Baca, Arthur M

“…Gallium is a semi-metallic element known since the 1930s to have antimicrobial activity. This activity stems primarily from gallium's ability to mimic…”
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Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea by Houinei, Wendy, Godornes, Charmie, Kapa, August, Knauf, Sascha, Mooring, Eric Q, González-Beiras, Camila, Watup, Ronald, Paru, Raymond, Advent, Paul, Bieb, Sivauk, Sanz, Sergi, Bassat, Quique, Spinola, Stanley M, Lukehart, Sheila A, Mitjà, Oriol

“…Haemophilus ducreyi and Treponema pallidum subsp. pertenue are major causes of leg ulcers in children in Africa and the Pacific Region. We investigated the…”
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Quantitation of rabbit cytokine mRNA by real-time RT-PCR by Godornes, Charmie, Leader, Brandon Troy, Molini, Barbara J., Centurion-Lara, Arturo, Lukehart, Sheila A.

“…Fundamental understanding of rabbit immunology and the use of the rabbit as a disease model have long been hindered by the lack of immunological assays…”
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Yaws re-emergence and bacterial drug resistance selection after mass administration of azithromycin: a genomic epidemiology investigation by Beale, Mathew A, Noguera-Julian, Marc, Godornes, Charmie, Casadellà, Maria, González-Beiras, Camila, Parera, Mariona, Kapa Jnr, August, Houinei, Wendy, Wangi, James, Corbacho-Monne, Marc, Paredes, Roger, Gonzalez-Candelas, Fernando, Marks, Michael, Lukehart, Sheila A, Thomson, Nicholas R, Mitjà, Oriol

“…In a longitudinal study assessing the WHO strategy for yaws eradication using mass azithromycin treatment, we observed resurgence of yaws cases with dominance…”
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T cell response to intact SARS-CoV-2 includes coronavirus cross-reactive and variant-specific components by Jing, Lichen, Wu, Xia, Krist, Maxwell P, Hsiang, Tien-Ying, Campbell, Victoria L, McClurkan, Christopher L, Favors, Sydney M, Hemingway, Lawrence A, Godornes, Charmie, Tong, Denise Q, Selke, Stacy, LeClair, Angela C, Pyo, Chu-Woo, Geraghty, Daniel E, Laing, Kerry J, Wald, Anna, Gale, Jr, Michael, Koelle, David M

“…SARS-CoV-2 provokes a robust T cell response. Peptide-based studies exclude antigen processing and presentation biology, which may influence T cell detection…”
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Evaluation of Azithromycin Resistance in Treponema pallidum Specimens From Madagascar by Van Damme, Kathleen, Behets, Frieda, Ravelomanana, Noro, Godornes, Charmie, Khan, Maria, Randrianasolo, Bodo, Rabenja, Ny Lovaniaina, Lukehart, Sheila, Cohen, Myron, Hook, Edward

“…Treponema pallidum resistance to azithromycin has been documented in the US, Canada, and Ireland. We found no evidence of resistance to azithromycin in…”
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Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study by Mitjà, Oriol, González-Beiras, Camila, Godornes, Charmie, Kolmau, Reman, Houinei, Wendy, Abel, Haina, Kapa, August, Paru, Raymond, Bieb, Sibauk V, Wangi, James, Sanz, Sergi, Asiedu, Kingsley, Lukehart, Sheila A, Bassat, Quique

“…Treatment of latent yaws is a crucial component of the WHO yaws eradication strategy to prevent relapse and the resulting transmission to uninfected children…”
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Azithromycin-Resistant Syphilis Infection: San Francisco, California, 2000–2004 by Mitchell, Samuel J., Engelman, Joseph, Kent, Charlotte K., Lukehart, Sheila A., Godornes, Charmie, Klausner, Jeffrey D.

“…Background. The incidence of syphilis has been increasing in the United States since reaching a nadir in 2000. Several clinical trials have demonstrated that…”
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CD4⁺ Lymphocytes and Gamma Interferon Predominate in Local Immune Responses in Early Experimental Syphilis by Leader, Brandon T, Godornes, Charmie, VanVoorhis, Wesley C, Lukehart, Sheila A

“…The clearance of Treponema pallidum subsp. pallidum from early syphilis lesions involves infiltration of a large number of mononuclear cells and is…”
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Quantitative Analysis of tpr Gene Expression in Treponema pallidum Isolates: Differences among Isolates and Correlation with T-Cell Responsiveness in Experimental Syphilis by GIACANI, Lorenzo, MOLINI, Barbara, GODORNES, Charmie, BARRETT, Lynn, VAN VOORHIS, Wesley, CENTURION-LARA, Arturo, LUKEHART, Sheila A

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