Search Results - "Godoi, Paulo H"

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK) by Asquith, Christopher R. M, Berger, Benedict-Tilman, Wan, Jing, Bennett, James M, Capuzzi, Stephen J, Crona, Daniel J, Drewry, David H, East, Michael P, Elkins, Jonathan M, Fedorov, Oleg, Godoi, Paulo H, Hunter, Debra M, Knapp, Stefan, Müller, Susanne, Torrice, Chad D, Wells, Carrow I, Earp, H. Shelton, Willson, Timothy M, Zuercher, William J

“…We describe SGC-GAK-1 (11), a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK), together with a structurally related negative…”
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WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop by Agajanian, Megan J., Walker, Matthew P., Axtman, Alison D., Ruela-de-Sousa, Roberta R., Serafin, D. Stephen, Rabinowitz, Alex D., Graham, David M., Ryan, Meagan B., Tamir, Tigist, Nakamichi, Yuko, Gammons, Melissa V., Bennett, James M., Couñago, Rafael M., Drewry, David H., Elkins, Jonathan M., Gileadi, Carina, Gileadi, Opher, Godoi, Paulo H., Kapadia, Nirav, Müller, Susanne, Santiago, André S., Sorrell, Fiona J., Wells, Carrow I., Fedorov, Oleg, Willson, Timothy M., Zuercher, William J., Major, Michael B.

“…β-Catenin-dependent WNT signal transduction governs development, tissue homeostasis, and a vast array of human diseases. Signal propagation through a…”
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Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase by Asquith, Christopher R. M., Laitinen, Tuomo, Bennett, James M., Godoi, Paulo H., East, Michael P., Tizzard, Graham J., Graves, Lee M., Johnson, Gary L., Dornsife, Ronna E., Wells, Carrow I., Elkins, Jonathan M., Willson, Timothy M., Zuercher, William J.

“…4‐Anilinoquinolines were identified as potent and narrow‐spectrum inhibitors of the cyclin G associated kinase (GAK), an important regulator of viral and…”
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Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations by Couñago, Rafael M., Allerston, Charles K., Savitsky, Pavel, Azevedo, Hatylas, Godoi, Paulo H., Wells, Carrow I., Mascarello, Alessandra, de Souza Gama, Fernando H., Massirer, Katlin B., Zuercher, William J., Guimarães, Cristiano R. W., Gileadi, Opher

“…The human genome encodes two active Vaccinia-related protein kinases (VRK), VRK1 and VRK2. These proteins have been implicated in a number of cellular…”
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1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors by Asquith, Christopher R M, Godoi, Paulo H, Couñago, Rafael M, Laitinen, Tuomo, Scott, John W, Langendorf, Christopher G, Oakhill, Jonathan S, Drewry, David H, Zuercher, William J, Koutentis, Panayiotis A, Willson, Timothy M, Kalogirou, Andreas S

“…We demonstrate for the first time that 4 -1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using…”
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TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors by Madiraju, Charitha, Welsh, Kate, Cuddy, Michael P, Godoi, Paulo H, Pass, Ian, Ngo, Tram, Vasile, Stefan, Sergienko, Eduard A, Diaz, Paul, Matsuzawa, Shu-Ichi, Reed, John C

“…UBC13 is a noncanonical ubiquitin conjugating enzyme (E2) that has been implicated in a variety of cellular signaling processes due to its ability to catalyze…”
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Structure of the Thiazole Biosynthetic Enzyme THI1 from Arabidopsis thaliana by Godoi, Paulo H.C., Galhardo, Rodrigo S., Luche, Douglas D., Van Sluys, Marie-Anne, Menck, Carlos F.M., Oliva, Glaucius

“…Thiamin pyrophosphate is an essential coenzyme in all organisms that depend on fermentation, respiration or photosynthesis to produce ATP. It is synthesized…”
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Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors by Henderson, Scott H, Sorrell, Fiona, Bennett, James, Fedorov, Oleg, Hanley, Marcus T, Godoi, Paulo H, Ruela de Sousa, Roberta, Robinson, Sean, Ashall-Kelly, Alexander, Hopkins Navratilova, Iva, Walter, Daryl S, Elkins, Jonathan M, Ward, Simon E

“…Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) regulates the proliferation and differentiation of neuronal progenitor cells during brain development…”
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Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target

“…Targeting parasite's protein kinaseMalaria elimination goals are constantly eroded by the challenge of emerging drug and insecticide resistance. Alam et al…”
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Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases by Henderson, Scott H., Sorrell, Fiona J., Bennett, James M., Fedorov, Oleg, Hanley, Marcus T., Godoi, Paulo H., Ruela de Sousa, Roberta, Robinson, Sean, Navratilova, Iva Hopkins, Elkins, Jonathan M., Ward, Simon E.

“…Selective inhibitors of DYRK1A are of interest for the treatment of cancer, Type 2 diabetes and neurological disorders. Optimization of imidazo…”
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Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors by Takarada, Jéssica E, Cunha, Micael R, Almeida, Vitor M, Vasconcelos, Stanley N S, Santiago, André S, Godoi, Paulo H, Salmazo, Anita, Ramos, Priscila Z, Fala, Angela M, de Souza, Lucas R, Da Silva, Italo E P, Bengtson, Mario H, Massirer, Katlin B, Couñago, Rafael M

“…The dual-specificity protein kinase MKK3 has been implicated in tumor cell proliferation and survival, yet its precise role in cancer remains inconclusive. A…”
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Identification and Optimization of 4-Anilinoquinolines as Inhibitors of CyclinG Associated Kinase by Asquith, Christopher R M, Laitinen, Tuomo, Bennett, James M, Godoi, Paulo H, East, Michael P, Tizzard, Graham J, Graves, Lee M, Johnson, Gary L, Dornsife, Ronna E, Wells, Carrow I, Elkins, Jonathan M, Willson, Timothy M, Zuercher, William J

“…4-Anilinoquinolines were identified as potent and narrow-spectrum inhibitors of the cyclinG associated kinase (GAK), an important regulator of viral and…”
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Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B by Segretti, Natanael D., Takarada, Jéssica E., Ferreira, Marcos A., da Silva Santiago, André, Teodoro, Bruno V.M., Damião, Mariana C.F.C.B., Godoi, Paulo H., Cunha, Micael R., Fala, Angela M., Ramos, Priscila Z., Ishikawa, Eloisa E., Mascarello, Alessandra, Serafim, Ricardo A.M., Azevedo, Hatylas, Guimarães, Cristiano R.W., Couñago, Rafael M.

“…[Display omitted] The discovery of potent and selective inhibitors for understudied kinases can provide relevant pharmacological tools to illuminate their…”
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Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors by Profeta, Gerson S., dos Reis, Caio V., Santiago, André da S., Godoi, Paulo H. C., Fala, Angela M., Wells, Carrow I., Sartori, Roger, Salmazo, Anita P. T., Ramos, Priscila Z., Massirer, Katlin B., Elkins, Jonathan M., Drewry, David H., Gileadi, Opher, Couñago, Rafael M.

“…Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CAMKK2) acts as a signaling hub, receiving signals from various regulatory pathways and decoding them via…”
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Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors by Santiago, André da Silva, Couñago, Rafael M., Ramos, Priscila Zonzini, Godoi, Paulo H. C., Massirer, Katlin B., Gileadi, Opher, Elkins, Jonathan M.

“…The calcium/calmodulin-dependent protein kinases (CAMKKs) are upstream activators of CAMK1 and CAMK4 signalling and have important functions in neural…”
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Orphan Nuclear Receptor NR4A1 Binds a Novel Protein Interaction Site on Anti-apoptotic B Cell Lymphoma Gene 2 Family Proteins by Godoi, Paulo H.C., Wilkie-Grantham, Rachel P., Hishiki, Asami, Sano, Renata, Matsuzawa, Yasuko, Yanagi, Hiroko, Munte, Claudia E., Chen, Ya, Yao, Yong, Marassi, Francesca M., Kalbitzer, Hans R., Matsuzawa, Shu-ichi, Reed, John C.

“…B cell lymphoma gene 2 (Bcl-2) family proteins are key regulators of programmed cell death and important targets for drug discovery. Pro-apoptotic and…”
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Validation of the protein kinase Pf CLK3 as a multistage cross-species malarial drug target by Alam, Mahmood M, Sanchez-Azqueta, Ana, Janha, Omar, Flannery, Erika L, Mahindra, Amit, Mapesa, Kopano, Char, Aditya B, Sriranganadane, Dev, Brancucci, Nicolas M B, Antonova-Koch, Yevgeniya, Crouch, Kathryn, Simwela, Nelson Victor, Millar, Scott B, Akinwale, Jude, Mitcheson, Deborah, Solyakov, Lev, Dudek, Kate, Jones, Carolyn, Zapatero, Cleofé, Doerig, Christian, Nwakanma, Davis C, Vázquez, Maria Jesús, Colmenarejo, Gonzalo, Lafuente-Monasterio, Maria Jose, Leon, Maria Luisa, Godoi, Paulo H C, Elkins, Jon M, Waters, Andrew P, Jamieson, Andrew G, Álvaro, Elena Fernández, Ranford-Cartwright, Lisa C, Marti, Matthias, Winzeler, Elizabeth A, Gamo, Francisco Javier, Tobin, Andrew B

“…The requirement for next-generation antimalarials to be both curative and transmission-blocking necessitates the identification of previously undiscovered…”
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A TR3/Nur77 peptide-based high-throughput fluorescence polarization screen for small molecule Bcl-B inhibitors by Yip, Kenneth W, Godoi, Paulo H C, Zhai, Dayong, Garcia, Xochella, Cellitti, Jason F, Cuddy, Michael, Gerlic, Motti, Chen, Ya, Satterthwait, Arnold, Vasile, Stefan, Sergienko, Eduard, Reed, John C

“…Nuclear receptor TR3/Nur77/NR4A1 binds several antiapoptotic Bcl-2-family proteins (Bcl-B, Bcl-2, Bfl-1) in a non-BH3-dependent manner. A 9-amino-acid peptide…”
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Binding and structural analyses of potent inhibitors of the human Ca 2+ /calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors by Profeta, Gerson S, Dos Reis, Caio V, Santiago, André da S, Godoi, Paulo H C, Fala, Angela M, Wells, Carrow I, Sartori, Roger, Salmazo, Anita P T, Ramos, Priscila Z, Massirer, Katlin B, Elkins, Jonathan M, Drewry, David H, Gileadi, Opher, Couñago, Rafael M

“…Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CAMKK2) acts as a signaling hub, receiving signals from various regulatory pathways and decoding them via…”
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A polymorphism in endostatin, an angiogenesis inhibitor, predisposes for the development of prostatic adenocarcinoma by IUGHETTI, Paula, SUZUKI, Oscar, MOREIRA-FILHO, Carlos Alberto, SIMOSON, Andrew, OLIVA, Glaucius, PASSOS-BUENO, Maria Rita, GODOI, Paulo H. C, FERREIRA ALVES, Venancio Avancini, SERTIE, Andrea L, ZORICK, Todd, SOARES, Fernando, CAMARGO, Anamaria, MOREIRA, Eloisa S, DI LORETO, Celso

“…We have performed association studies between a novel coding single nucleotide polymorphism (D104N) in endostatin, one of the most potent inhibitors of…”
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