Search Results - "Godiksen, Sine"

Low ABCB1 gene expression is an early event in colorectal carcinogenesis by Andersen, Vibeke, Vogel, Ulla, Godiksen, Sine, Frenzel, Franz B, Sæbø, Mona, Hamfjord, Julian, Kure, Elin, Vogel, Lotte K

“…The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating…”
Get full text

Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis by Vogel, Lotte K, Sæbø, Mona, Høyer, Helle, Kopp, Tine Iskov, Vogel, Ulla, Godiksen, Sine, Frenzel, Franz B, Hamfjord, Julian, Bowitz-Lothe, Inger Marie, Johnson, Egil, Kure, Elin H, Andersen, Vibeke

“…Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is…”
Get full text

Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation by Szabo, Roman, Uzzun Sales, Katiuchia, Kosa, Peter, Shylo, Natalia A, Godiksen, Sine, Hansen, Karina K, Friis, Stine, Gutkind, J Silvio, Vogel, Lotte K, Hummler, Edith, Camerer, Eric, Bugge, Thomas H

“…Loss of either hepatocyte growth factor activator inhibitor (HAI)-1 or -2 is associated with embryonic lethality in mice, which can be rescued by the…”
Get full text

Transport via the Transcytotic Pathway Makes Prostasin Available as a Substrate for Matriptase by Friis, Stine, Godiksen, Sine, Bornholdt, Jette, Selzer-Plon, Joanna, Rasmussen, Hanne Borger, Bugge, Thomas H., Lin, Chen-Yong, Vogel, Lotte K.

“…The matriptase-prostasin proteolytic cascade is essential for epidermal tight junction formation and terminal epidermal differentiation. This proteolytic…”
Get full text

The level of claudin-7 is reduced as an early event in colorectal carcinogenesis by Bornholdt, Jette, Friis, Stine, Godiksen, Sine, Poulsen, Steen S, Santoni-Rugiu, Eric, Bisgaard, Hanne C, Lothe, Inger M B, Ikdahl, Tone, Tveit, Kjell M, Johnson, Egil, Kure, Elin H, Vogel, Lotte K

“…Compromised epithelial barriers are found in dysplastic tissue of the gastrointestinal tract. Claudins are transmembrane proteins important for tight…”
Get full text

Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase by Larsen, Brian R., Steffensen, Simon D.R., Nielsen, Nis V.L., Friis, Stine, Godiksen, Sine, Bornholdt, Jette, Soendergaard, Christoffer, Nonboe, Annika W., Andersen, Martin N., Poulsen, Steen S., Szabo, Roman, Bugge, Thomas H., Lin, Chen-Yong, Skovbjerg, Hanne, Jensen, Jan K., Vogel, Lotte K.

“…Hepatocyte growth factor activator inhibitor-2 (HAI-2) is an inhibitor of many proteases in vitro, including the membrane-bound serine protease, matriptase…”
Get full text

Expression of NDRG2 is down-regulated in high-risk adenomas and colorectal carcinoma by Lorentzen, Anders, Vogel, Lotte K, Lewinsky, Rikke H, Saebø, Mona, Skjelbred, Camilla F, Godiksen, Sine, Hoff, Geir, Tveit, Kjell M, Lothe, Inger Marie Bowitz, Ikdahl, Tone, Kure, Elin H, Mitchelmore, Cathy

“…It has recently been shown that NDRG2 mRNA is down-regulated or undetectable in several human cancers and cancer cell-lines. Although the function of NDRG2 is…”
Get full text

Detection of active matriptase using a biotinylated chloromethyl ketone peptide by Godiksen, Sine, Soendergaard, Christoffer, Friis, Stine, Jensen, Jan K, Bornholdt, Jette, Sales, Katiuchia Uzzun, Huang, Mingdong, Bugge, Thomas H, Vogel, Lotte K

“…Matriptase is a member of the family of type II transmembrane serine proteases that is essential for development and maintenance of several epithelial tissues…”
Get full text

Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary by Godiksen, Sine, Selzer-Plon, Joanna, Pedersen, Esben D K, Abell, Kathrine, Rasmussen, Hanne B, Szabo, Roman, Bugge, Thomas H, Vogel, Lotte K

“…HAI-1 [HGF (hepatocyte growth factor) activator inhibitor-1] is a Kunitz-type transmembrane serine protease inhibitor that forms inhibitor complexes with the…”
Get more information

A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation by Friis, Stine, Uzzun Sales, Katiuchia, Godiksen, Sine, Peters, Diane E, Lin, Chen-Yong, Vogel, Lotte K, Bugge, Thomas H

“…Matriptase and prostasin are part of a cell surface proteolytic pathway critical for epithelial development and homeostasis. Here we have used a reconstituted…”
Get full text

Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis by Sales, K U, Friis, S, Konkel, J E, Godiksen, S, Hatakeyama, M, Hansen, K K, Rogatto, S R, Szabo, R, Vogel, L K, Chen, W, Gutkind, J S, Bugge, T H

“…The membrane-anchored serine protease, matriptase, is consistently dysregulated in a range of human carcinomas, and high matriptase activity correlates with…”
Get full text

A Matriptase-Prostasin Reciprocal Zymogen Activation Complex with Unique Features by Friis, Stine, Uzzun Sales, Katiuchia, Godiksen, Sine, Peters, Diane E., Lin, Chen-Yong, Vogel, Lotte K., Bugge, Thomas H.

“…Matriptase and prostasin are part of a cell surface proteolytic pathway critical for epithelial development and homeostasis. Here we have used a reconstituted…”
Get full text

Correction: Low ABCB1 Gene Expression Is an Early Event in Colorectal Carcinogenesis by Andersen, Vibeke, Vogel, Ulla, Godiksen, Sine, Frenzel, Franz B., Sæbø, Mona, Hamfjord, Julian, Kure, Elin, Vogel, Lotte K.

Get full text

Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis: e105254 by Vogel, Lotte K, Saeboe, Mona, Hoeyer, Helle, Kopp, Tine Iskov, Vogel, Ulla, Godiksen, Sine, Frenzel, Franz B, Hamfjord, Julian, Bowitz-Lothe, Inger Marie, Johnson, Egil

“…Background & Aims Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by…”
Get full text

Low ABCB1 Gene Expression Is an Early Event in Colorectal Carcinogenesis. e72119 by Andersen, Vibeke, Vogel, Ulla, Godiksen, Sine, Frenzel, Franz B, Saeboe, Mona, Hamfjord, Julian, Kure, Elin, Vogel, Lotte K

“…The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating…”
Get full text

Correction: Low Gene Expression Is an Early Event in Colorectal Carcinogenesis by Vibeke Andersen, Ulla Vogel, Sine Godiksen, Franz B. Frenzel, Mona Sæbø, Julian Hamfjord, Elin Kure, Lotte K. Vogel

Get full text