Search Results - "Godfrey, D I"

Natural killer T cell defects in multiple myeloma and the impact of lenalidomide therapy by Chan, A. C., Neeson, P., Leeansyah, E., Tainton, K., Quach, H., Prince, H. M., Harrison, S. J., Godfrey, D. I., Ritchie, D., Berzins, S. P.

“…Summary The causes of multiple myeloma (MM) remain obscure and there are few known risk factors; however, natural killer T (NKT) cell abnormalities have been…”
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Ex‐vivo analysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4+ and CD4− subsets by Chan, A. C., Leeansyah, E., Cochrane, A., d' Udekem d' Acoz, Y., Mittag, D., Harrison, L. C., Godfrey, D. I., Berzins, S. P.

“…Summary Our understanding of human type 1 natural killer T (NKT) cells has been heavily dependent on studies of cells from peripheral blood. These have…”
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In‐vivo stimulation of macaque natural killer T cells with α‐galactosylceramide by Fernandez, C. S., Jegaskanda, S., Godfrey, D. I., Kent, S. J.

“…Summary Natural killer T cells are a potent mediator of anti‐viral immunity in mice, but little is known about the effects of manipulating NKT cells in…”
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Testing the NKT cell hypothesis in lenalidomide-treated myelodysplastic syndrome patients by Chan, A C, Neeson, P, Leeansyah, E, Tainton, K, Quach, H, Prince, H M, Godfrey, D I, Ritchie, D, Berzins, S P

“…Myelodysplastic syndrome (MDS) comprises a group of clonal bone marrow disorders characterized by ineffective hematopoiesis and increased predisposition to…”
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Immune characterization of an individual with an exceptionally high natural killer T cell frequency and her immediate family by Chan, A. C., Serwecinska, L., Cochrane, A., Harrison, L. C., Godfrey, D. I., Berzins, S. P.

“…Summary Natural killer T cells (NKT) are a regulatory subset of T lymphocytes whose frequency in peripheral blood is highly variable within the human…”
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A Central Role for Thymic Emigrants in Peripheral T Cell Homeostasis by Berzins, S. P., Godfrey, D. I., J. F. A. P. Miller, Boyd, R. L.

“…After initial seeding by thymic emigrants, homeostatic regulation of the T cell pool has been thought to occur entirely within the periphery. Here we report…”
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Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation by Godfrey, DI, Kennedy, J, Mombaerts, P, Tonegawa, S, Zlotnik, A

“…TCR-beta gene rearrangement or expression is necessary and sufficient for the progression of early alpha beta thymocyte differentiation from the CD3-CD4-CD8-…”
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Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals by Chen, Z, Wang, H, D'Souza, C, Sun, S, Kostenko, L, Eckle, S B G, Meehan, B S, Jackson, D C, Strugnell, R A, Cao, H, Wang, N, Fairlie, D P, Liu, L, Godfrey, D I, Rossjohn, J, McCluskey, J, Corbett, A J

“…Despite recent breakthroughs in identifying mucosal-associated invariant T (MAIT) cell antigens (Ags), the precise requirements for in vivo MAIT cell responses…”
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CD1d-Restricted NKT Cells: An Interstrain Comparison by Hammond, Kirsten J. L, Pellicci, Daniel G, Poulton, Lynn D, Naidenko, Olga V, Scalzo, Anthony A, Baxter, Alan G, Godfrey, Dale I

“…CD1d-restricted Valpha14-Jalpha281 invariant alphabetaTCR(+) (NKT) cells are well defined in the C57BL/6 mouse strain, but they remain poorly characterized in…”
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IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival by Webster, K E, Kim, H-O, Kyparissoudis, K, Corpuz, T M, Pinget, G V, Uldrich, A P, Brink, R, Belz, G T, Cho, J-H, Godfrey, D I, Sprent, J

“…Natural killer T (NKT) cells are innate-like T cells that rapidly recognize pathogens and produce cytokines that shape the ensuing immune response…”
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CD3 bright signals on γδ T cells identify IL‐17A‐producing Vγ6Vδ1 + T cells by Paget, C, Chow, M T, Gherardin, N A, Beavis, P A, Uldrich, A P, Duret, H, Hassane, M, Souza‐Fonseca‐Guimaraes, F, Mogilenko, D A, Staumont‐Sallé, D, Escalante, N K, Hill, G R, Neeson, P, Ritchie, D S, Dombrowicz, D, Mallevaey, T, Trottein, F, Belz, G T, Godfrey, D I, Smyth, M J

“…Interleukin‐17A (IL‐17A) is a pro‐inflammatory cytokine that has an important role at mucosal sites in a wide range of immune responses including infection,…”
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CD3bright signals on γδ T cells identify IL‐17A‐producing Vγ6Vδ1+ T cells by Paget, C, Chow, M T, Gherardin, N A, Beavis, P A, Uldrich, A P, Duret, H, Hassane, M, Souza‐Fonseca‐Guimaraes, F, Mogilenko, D A, Staumont‐Sallé, D, Escalante, N K, Hill, G R, Neeson, P, Ritchie, D S, Dombrowicz, D, Mallevaey, T, Trottein, F, Belz, G T, Godfrey, D I, Smyth, M J

“…Interleukin‐17A (IL‐17A) is a pro‐inflammatory cytokine that has an important role at mucosal sites in a wide range of immune responses including infection,…”
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Uranium series isotopes in the Avon Valley, Nova Scotia by Kronfeld, J, Godfrey-Smith, D.I, Johannessen, D, Zentilli, M

“…An U-series isotopic study was carried out in the waters of the Avon Valley, Nova Scotia. The fresh and acidic recharge waters flow rapidly through the…”
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In-vivo stimulation of macaque natural killer T cells with [alpha]-galactosylceramide by Fernandez, C S, Jegaskanda, S, Godfrey, D I, Kent, S J

“…Summary Natural killer T cells are a potent mediator of anti-viral immunity in mice, but little is known about the effects of manipulating NKT cells in…”
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Phenotypic and functional characterization of c-kit expression during intrathymic T cell development by Godfrey, DI, Zlotnik, A, Suda, T

“…We have studied the expression and function of c-kit on subsets of mouse thymocytes. c-kit was primarily expressed on subpopulations of CD4-CD8-CD3- triple…”
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A fresh look at tumor immunosurveillance and immunotherapy by Smyth, Mark J, Godfrey, Dale I, Trapani, Joseph A

“…Despite major advances in our understanding of adaptive immunity and dendritic cells, consistent and durable responses to cancer vaccines remain elusive and…”
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CD1-restricted T cells and tumor immunity by Swann, J B, Coquet, J M C, Smyth, M J, Godfrey, D I

“…CD1d-restricted T cells (NKT cells) are potent regulators of a broad range of immune responses. In particular, an abundance of research has focussed on the…”
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Optical dating of sediments by Huntley, D. J, Godfrey-Smith, D. I, Thewalt, M. L. W

“…A new method for dating sediments is proposed, which determines the time since the sediment was last exposed to sunlight. An argon-ion laser is used to excite…”
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Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma by Smyth, M J, Thia, K Y, Street, S E, MacGregor, D, Godfrey, D I, Trapani, J A

“…Immune surveillance by cytotoxic lymphocytes against cancer has been postulated for decades, but direct evidence for the role of cytotoxic lymphocytes in…”
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Differential tumor surveillance by natural killer (NK) and NKT cells by Smyth, M J, Thia, K Y, Street, S E, Cretney, E, Trapani, J A, Taniguchi, M, Kawano, T, Pelikan, S B, Crowe, N Y, Godfrey, D I

“…Natural tumor surveillance capabilities of the host were investigated in six different mouse tumor models where endogenous interleukin (IL)-12 does or does not…”
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